The presentation and regulation of the IL-8 network in the epithelial cancer stem-like cell niche in patients with colorectal cancer

Cui, Guanglin; Gui, Li; Pang, Zhigang; Florholmen, Jon; Goll, Rasmus

doi:10.1016/j.biopha.2022.113252

Cited by 12 publications

(8 citation statements)

References 74 publications

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“…In the present study, it was demonstrated that lycopene, both free lycopene from red guava and LPG in a nanoemulsion, led to an increase in IL-8 production compared to controls ( Figure 3 C). The literature contains studies with prostate [ 43 ], ovarian [ 44 ] and colorectal [ 45 ] cancers that demonstrate cell proliferation and migration, as well as an inflammatory condition stimulated by increases in the production of the cytokine IL-8. However, studies have shown that glycolic acid, present in fruits, can decrease skin inflammation resulting from exposure to ultraviolet solar irradiation, as a result of decreased expression of IL-8 genes [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System

et al. 2023

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In recent years, lycopene has been highlighted due to its antioxidant and anti-inflammatory properties, associated with a beneficial effect on human health. The aim of this study was to advance the studies of antioxidant and anti-inflammatory mechanisms on human keratinocytes cells (HaCaT) of a self-emulsifying drug delivery system (SEDDS) loaded with lycopene purified from red guava (nanoLPG). The characteristics of nanoLPG were a hydrodynamic diameter of 205 nm, a polydispersity index of 0.21 and a zeta potential of −20.57, providing physical stability for the nanosystem. NanoLPG demonstrated antioxidant capacity, as shown using the ORAC methodology, and prevented DNA degradation (DNA agarose). Proinflammatory activity was evaluated by quantifying the cytokines TNF-α, IL-6 and IL-8, with only IL-8 showing a significant increase (p < 0.0001). NanoLPG showed greater inhibition of the tyrosinase and elastase enzymes, involved in the skin aging process, compared to purified lycopene (LPG). In vitro treatment for 24 h with 5.0 µg/mL of nanoLPG did not affect the viability of HaCaT cells. The ultrastructure of HaCaT cells demonstrated the maintenance of morphology. This contrasts with endoplasmic reticulum stresses and autophagic vacuoles when treated with LPG after stimulation or not with LPS. Therefore, the use of lycopene in a nanoemulsion may be beneficial in strategies and products associated with skin health.

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Section: Resultsmentioning

confidence: 99%

Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System

et al. 2023

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“…Along with other members of the TNF superfamily, IL-8 is involved in various physiopathological processes and thus can affect tumor growth, survival and invasion. IL-8 network activation in the niche of cancer stem-like cells (CSCs) could serve as a switch from the precancerous adenoma stage to the colorectal cancer stage (23). IL-8 mRNA expression was found to be upregulated in tumor tissues compared with normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Elevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma

Omer Uslukaya,

Zeynep Yegin,

Fatih Taskesen

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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“…Recent evidence has shown that MSCs are an important source of IL-8, and MSC-derived IL-8 levels are even higher than CRC cell-derived IL-8 levels in CRC ( 122 ), which stimulates angiogenesis in a paracrine manner ( 113 ). Furthermore, the activation of the IL-8 network, modulated by a set of cytokines such as IL-1β ( 123 ), in the TME may contribute to the establishment of an immunosuppressive CSC niche ( 11 , 113 – 115 ). In a recent study, we showed that the IL-8 niche of CSCs is regulated by IL-1β throughout the colorectal adenoma-carcinoma sequence ( 123 ).…”

Section: Role Of Cytokines As Communicators In Mediating Crosstalk Be...mentioning

confidence: 99%

“…Furthermore, the activation of the IL-8 network, modulated by a set of cytokines such as IL-1β ( 123 ), in the TME may contribute to the establishment of an immunosuppressive CSC niche ( 11 , 113 – 115 ). In a recent study, we showed that the IL-8 niche of CSCs is regulated by IL-1β throughout the colorectal adenoma-carcinoma sequence ( 123 ). Interestingly, recent studies also reported ( 124 ) that IL-8-derived from CRC cells with high stemness features stimulated the process of angiogenesis.…”

Section: Role Of Cytokines As Communicators In Mediating Crosstalk Be...mentioning

confidence: 99%

Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications

et al. 2022

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The majority of colorectal cancers (CRCs) are thought to arise from precancerous adenomas. Upon exposure to diverse microenvironmental factors, precancerous stem cells (pCSCs) undergo complex genetic/molecular changes and gradually progress to form cancer stem cells (CSCs). Accumulative evidence suggests that the pCSC/CSC niche is an inflammatory dominated milieu that contains different cytokines that function as the key communicators between pCSCs/CSCs and their niche and have a decisive role in promoting CRC development, progression, and metastasis. In view of the importance and increasing data about cytokines in modulating pCSCs/CSC stemness properties and their significance in CRC, this review summarizes current new insights of cytokines, such as interleukin (IL)-4, IL-6, IL-8, IL-17A, IL-22, IL-23, IL-33 and interferon (IFN)-γ, involving in the modulation of pCSC/CSC properties and features in precancerous and cancerous lesions and discusses the possible mechanisms of adenoma progression to CRCs and their therapeutic potential.

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The presentation and regulation of the IL-8 network in the epithelial cancer stem-like cell niche in patients with colorectal cancer

Cited by 12 publications

References 74 publications

Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System

Potential Biological Properties of Lycopene in a Self-Emulsifying Drug Delivery System

Elevated expression levels of COX-2, IL-8 and VEGF in colon adenocarcinoma

Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications

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