The Presentation, Recognition and Management of Bipolar Depression in Primary Care

Cerimele, Joseph M.; Chwastiak, Lydia; Chan, Ya Fen; Harrison, David A; Unützer, Jürgen

doi:10.1007/s11606-013-2545-7

Cited by 19 publications

(8 citation statements)

References 95 publications

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“…If presenting to primary care, these patients may require immediate referral to specialist hospital care because of the risk of harm to self or others. However, more common in the primary care setting is the presentation of patients with depressive symptoms, who require a differentiation between BD and MDD (Cerimele, Chwastiak, Chan, Harrison, & Unutzer, 2013; Sasdelli et al., 2013). For this reason, all patients presenting with depressive symptoms should be assessed for a history of manic or hypomanic symptoms (Cerimele et al., 2013; Sasdelli et al., 2013; Valente & Kennedy, 2010).…”

Section: Diagnostic Criteria For Bdmentioning

confidence: 99%

Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses

McCormick

Murray

McNew

2015

Journal of the American Association of Nurse Practitioners

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Purpose This review article provides an overview of the frequency, burden of illness, diagnosis, and treatment of bipolar disorder (BD) from the perspective of the advanced practice nurses (APNs). Data sources PubMed searches were conducted using the following keywords: “bipolar disorder and primary care,” restricted to dates 2000 to present; “bipolar disorder and nurse practitioner”; and “bipolar disorder and clinical nurse specialist.” Selected articles were relevant to adult outpatient care in the United States, with a prioritization of articles written by APNs or published in nursing journals. Conclusions BD has a substantial lifetime prevalence in the population at 4%. Because the manic or depressive symptoms of BD tend to be severe and recurrent over a patient's lifetime, the condition is associated with significant burden to the individual, caregivers, and society. Clinician awareness that BD may be present increases the likelihood of successful recognition and appropriate treatment. A number of pharmacological and nonpharmacological treatments are available for acute and maintenance treatments, with the prospect of achieving reduced symptom burden and increased functioning for many patients. Implications for practice Awareness of the disease burden, diagnostic issues, and management choices in BD has the potential to enhance outcome in substantial proportions of patients.

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Section: Diagnostic Criteria For Bdmentioning

confidence: 99%

Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses

McCormick

Murray

McNew

2015

Journal of the American Association of Nurse Practitioners

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“…Bipolar disorder (BD) is a recurrent major psychiatry disease that causes disability worldwide and is associated with significant healthcare costs [1]. BD is associated with elevated risk of suicide attempts and deaths [2].…”

Section: Introductionmentioning

confidence: 99%

Comparing Lithium With Valproate for Clinical and Social Status of Bipolar Disorder Patients in Inter-Episode Interval: A Retrospective Comparative Study

2020

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“…People who develop depression are characterized by reduced energy, feelings of guilt, anorexia, and suicidal ideation. [34] Other symptoms include alterations in the cognitive capabilities, level of activity, speech, and other functions such as appetite, sleep, sexual activity, and biological rhythms. These disorders often result in impairment of social and occupational functioning and put a lot of emotional and financial burden on the patient and the community.…”

Section: Introductionmentioning

confidence: 99%

Gene expression pattern of CCL2, CCL3, and CXCL8 in patients with bipolar disorder

et al. 2019

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Background: Bipolar disorder (BD) is one of the most important psychiatric disorders in the world. There is evidence suggesting the role of inflammatory mediators such as chemokines in the etiology of BD. The objective of the current study was to evaluate the gene expression of CCL2 , CCL3 , and CXCL8 in patients with BD and compare them to healthy controls. Materials and Methods: A total of 48 patients with confirmed BD and 48 healthy controls enrolled in this study. All patients were recruited from April to August 2016 at Ibn-Sina Psychiatric Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. RNA was extracted from the whole blood samples and then cDNA was synthesized. Gene expression of CCL2 , CCL3 , and CXCL8 was measured using SYBR ® Green real-time polymerase chain reaction. The difference of delta-CT values between patients and healthy controls was compared with the independent samples t -tests. Results: CCL2 and CXCL8 genes expressed at higher levels in patients with BD as compared to healthy controls, but not significant. On the contrary, we found lower expression levels for CCL3 gene in our patients compared to healthy controls, but the difference was not statistically significant. Conclusion: Our findings do not show an association between the gene expression of CCL2 , CCL3 and CXCL8 and BD. Increasing the sample size and evaluation on the gene expression of other chemokines in depression and mania phases of BD might be helpful to get a better conclusion.

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The Presentation, Recognition and Management of Bipolar Depression in Primary Care

Cited by 19 publications

References 95 publications

Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses

Diagnosis and treatment of patients with bipolar disorder: A review for advanced practice nurses

Comparing Lithium With Valproate for Clinical and Social Status of Bipolar Disorder Patients in Inter-Episode Interval: A Retrospective Comparative Study

Gene expression pattern of CCL2, CCL3, and CXCL8 in patients with bipolar disorder

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