The Pressor Effect of the Antidiuretic Principle of the Posterior Pituitary in Orthostatic Hypotension 1

Braunwald, E.; Hn, Wagner

doi:10.1172/jci103398

Cited by 126 publications

(31 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the BPresponse to Octapressin apparently is caused by an increase in the vascular resistance of the systemic circulation. This is in agreement with previous studies with vasopressins reported by Wagner and Braunwald (1956) and Feruglio et al (1964). Part of the literature on CO with vasopressin and Octapressin however is at variance.…”

Section: Discussionsupporting

confidence: 94%

“…The increment of arterial blood pressure (BP) induced by vasopressin depends, for a major part, on an increase in the vascular resistance of the systemic circulation (Wagner and Braunwald, 1956;Page and Olmsted, 1963;Maxwell, 1965). The contribution of cardiac output (CO) to the rise in BP is less clear, as a decrease in CO (Longo et al, 1964;Maxwell, 1965), an increase in CO (Bezn~tk, 1959) and no change in CO (Wagner and Braunwald, 1956;Tsakiris et al, 1964) have been reported.…”

Section: ~Troductionmentioning

confidence: 99%

“…The contribution of cardiac output (CO) to the rise in BP is less clear, as a decrease in CO (Longo et al, 1964;Maxwell, 1965), an increase in CO (Bezn~tk, 1959) and no change in CO (Wagner and Braunwald, 1956;Tsakiris et al, 1964) have been reported.…”

Section: ~Troductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Jong¹,

McLeod²

1967

European Journal of Pharmacology

View full text Add to dashboard Cite

Effect of autonomic blocking agents on the cardiovascular effects of Octapressin in the rat, European J. Pharmacol. 1 (1967) 93-98.Cardiovascular effects of Octapressin were studied in anesthetized male albino rats. The effect of pretreatment with the following blocking agents was evaluated: atropine, phenoxybenzamine, propranolol, hexamethonium and chlorpromazine. A decrease in blood pressure and in heart rate was induced by phenoxybenzamine; propranolol treatment caused a decrease in heart rate and an increase in circulation time.Injections of 2, 6 and 18 mU Octapressin caused no changes in cardiac output or in central venous pressure. The increase in blood pressure following Octapressin was found to be dose-dependent in the saline-treated controls as well as in the rats pretreated with the autonomic blocking agents. The pressot response to Octapressin was increased by atropine, phenoxybenzamine, propranolol and chlorpromazine.From these data it is concluded that the increase in blood pressure following Octapressin is caused by an increase in vascular resistance in the systemic circulation.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: ~Troductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Jong¹,

McLeod²

1967

European Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

“…Additionally, in decapitated animals, this factor of displacement for vasopressin was 8,000 for doses that caused a 50-mmHg rise in systemic arterial pressure 33 . Consistent with these experimental findings is the observation that the dose-response curves for vasopressin in patients with idiopathic orthostatic hypotension (Shy-Drager's syndrome) were markedly displaced to the left when compared to those of normal subjects 34,35 . Similar findings have also been reported in brain-dead patients 36 .…”

Section: -A) Heart Rate (Hr) B) Cardiac Index (Ci) C) Mean Arterialsupporting

confidence: 61%

Infusão intravenosa de vasopressina causa efeitos cardiovasculares adversos dose-dependentes em cães anestesiados

Martins¹,

Sabha²,

Paganelli³

et al. 2010

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…Arginine-vasopressin (AVP) is endogenously released from the posterior pituitary gland in response to reduced plasma volume or increased serum osmolality and is most commonly regarded to as the anti-diuretic hormone [67]. Under normal conditions, its major role is in the regulation of water balance.…”

Section: What Is the Role Of Vasopressin Or Ddavp In Caffeine Toxicity?mentioning

confidence: 99%

Combined Butalbital/Acetaminophen/Caffeine Overdose: Case Files of the Robert Wood Johnson Medical School Toxicology Service

Bryczkowski

Geib

2012

J. Med. Toxicol.

View full text Add to dashboard Cite

A 40-year-old woman with no previous medical problems presented to the Emergency Department (ED) 2 h after ingesting an unknown amount of Fioricet® (butalbital/acetaminophen/caffeine), oxycodone, and fentanyl patches about 90 min prior to emergency medical service (EMS) dispatch. The patient's husband reported they had had a fight, and he went down to the basement; when he came back upstairs, he found the patient unconscious with an empty pill bottle. A call to the patient's pharmacy by ED staff revealed that the patient had her prescription for butalbital/acetaminophen/caffeine tablets refilled 5 days earlier and that she had convinced the pharmacist to override the refill amount to dispense 540 tablets; according to the pharmacist, the patient stated she was going on a trip to Italy and needed a 6-month supply. EMS personnel removed a fentanyl patch (unknown strength) from her skin. The source of the fentanyl and the strength and formulation of the oxycodone were not recorded. Prehospital treatment included naloxone 4 mg IV without any noticeable clinical response, insertion of a nasal trumpet, and initiation of bag-valve-mask ventilation. A fingerstick glucose was 137 mg/dL.On arrival to the ED, the patient was unconscious with the following vital signs: blood pressure, 98/54 mmHg; pulse, 72 beats/min; respiratory rate, 14 breaths/min; and pulse oximetry, 100 % on a non-rebreather mask.

show abstract

The Pressor Effect of the Antidiuretic Principle of the Posterior Pituitary in Orthostatic Hypotension 1

Cited by 126 publications

References 11 publications

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Effect of autonomic blocking agents on the cardiovascular effects of octapressin in the rat

Infusão intravenosa de vasopressina causa efeitos cardiovasculares adversos dose-dependentes em cães anestesiados

Combined Butalbital/Acetaminophen/Caffeine Overdose: Case Files of the Robert Wood Johnson Medical School Toxicology Service

Contact Info

Product

Resources

About