The pretreatment erythrocyte sedimentation rate predicts survival outcomes after surgery and adjuvant radiotherapy for extremity soft tissue sarcoma

Park, Geumju; Song, Si Yeol; Ahn, Jin‐Hee; Kim, Wanlim; Lee, Jong-Seok; Jeong, Seong‐Yun; Park, Jae Won; Choi, Eun Kyung; Choi, Won Ah; Jung, In Mok

doi:10.1186/s13014-019-1331-z

Cited by 14 publications

(11 citation statements)

References 35 publications

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“…The random-effects model demonstrated that an elevated CRP levels had significantly prognostic value for DSS (HR: 2.06; 95% CI: 1.32-3.22; P = 0.002), but with significant heterogeneity (I² = 84.0%; Figure 4). The correlation between CRP and DFS was demonstrated in five studies, and the pooled data illustrated that an elevated CRP level was associated with poor DFS (HR: 1.75; 95% CI: 1.38-2.23; P < 0.00001) (20,26,31,35,39). No heterogeneity (I² = 0%; Figure 4) was observed.…”

Section: Prognostic Value Of Elevated Crp For Os/dss/dfsmentioning

confidence: 88%

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Meta-Analysis of Hematological Biomarkers as Reliable Indicators of Soft Tissue Sarcoma Prognosis

Bai

Zhang

et al. 2020

Front. Oncol.

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Background: Several recent studies have reported the reliable prognostic effect of hematological biomarkers in various tumors. Yet, the prognostic value of these hematological markers in soft tissue sarcoma (STS) remains inconclusive. Thus, the aim of this meta-analysis was to check the effect of hematological markers on the prognosis of STS. Methods: We systematically searched for relevant papers published before October 2019 in the PubMed and EMBASE databases. Overall survival (OS) and disease-specific survival (DSS) were the primary outcome, whereas disease-free survival was the secondary outcome. A thorough study of hazard ratios (HR) and 95% of confidence intervals (CIs) was done for determining the prognostic significance. Results: We performed 23 studies that comprised of 4,480 patients with STS. The results revealed that higher neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), and platelet-to-lymphocyte ratio (PLR) were associated with poor OS/DFS (HR = 2.08/1.72, for NLR; HR = 1.92/1.75, for CRP, and HR = 1.86/1.61, for PLR). In contrast, a low lymphocyte-to-monocyte ratio (LMR) was relate to worse OS/DFS (HR = 2.01/1.90, for LMR). Moreover, pooled analysis illustrated that elevated NLR and CRP represents poor DSS, with HRs of 1.46 and 2.06, respectively. In addition, combined analysis revealed that higher Glasgow prognostic score (GPS) was linked to an adverse OS/DSS (HR = 2.35/2.77). Conclusion: Our meta-analysis suggested that hematological markers (NLR, CRP, PLR, LMR, and GPS) are one of the important prognostic indicators for patients affected by high-grade STS and patients with the STS being located in the extremity.

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Section: Prognostic Value Of Elevated Crp For Os/dss/dfsmentioning

confidence: 88%

“…The effect of CRP on the STS prognosis was demonstrated in five studies (19,22,26,31,35). The analysis showed that a higher CRP level is a useful prognostic marker for predicting survival rate (HR: 1.92, 95% CI: 1.52-2.42, P < 0.00001) with no heterogeneity between studies (I² = 0%; Figure 4).…”

Section: Prognostic Value Of Elevated Crp For Os/dss/dfsmentioning

confidence: 97%

Meta-Analysis of Hematological Biomarkers as Reliable Indicators of Soft Tissue Sarcoma Prognosis

Bai

Zhang

et al. 2020

Front. Oncol.

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“…Some other authors, such as Wu D., have associated an elevation in ESR of 77mm/h and CRP of 12 mg/l, with the severity of the condition 18,19 . Park et al observed elevated levels of CRP (> 0.14 mg/dL) and ESR (> 15 mm/h) related to general survival in a group of patients with sarcoma 20 .…”

Section: Original Studymentioning

confidence: 99%

Factors associated with survival in diabetic patients with rhino-orbito-cerebral mucormycosis

Martinez¹,

Lugo-Machado²,

Canché-Martín³

et al. 2021

Romanian Journal of Rhinology

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BACKGROUND. Mucormycosis is an emerging angioinvasive, potentially fatal infection caused by the ubiquitous filamentous fungi of the order Mucorales of the class Phycomycetes. They occur particularly in metabolically decompensated diabetic patients. OBJECTIVE. To evaluate the factors associated with survival in a group of diabetic patients with rhino-orbito-cerebral mucormycosis. MATERIAL AND METHODS. A case-control study of a series of cases from January 2013 to May 2020 was designed. Patients with diabetes mellitus and a diagnosis of rhino-orbito-cerebral mucormycosis were included. The clinical findings were considered, as well as age, gender, laboratory and radiological results, and mortality. For the statistical analysis, we used descriptive statistics, Mann Whitney U test. We considered a p-value equal to or less than 0.05 to indicate a statistically significant association or difference. Likewise, the odds ratio was used to determine the relative risk. RESULTS. 19 cases were included, with an average age of 60.8 years and female gender predominance. In 100% of the cases, nonseptate hyphae were identified in histopathological studies. We had a mortality of 7 (36.8%), where the rhino-orbital complications were the most frequent. The findings of CRP ≤23.1mm/L, an absolute neutrophil count ≥13.2 x1000 /µl and absence of bone erosion in the simple tomography, the rhino-orbital stage, could be related to greater survival. CONCLUSION. Our series presented mortality close to 40%. Age <64 years, CRP ≤23.1mm/L, absolute neutrophil count ≥13.2 x1000 /µl and absence of bone erosion in the simple tomography, rhino-orbital stage were associated with a better survival in our series.

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“…It is now well recognized that chronic inflammation is a risk factor for most types of cancer. Thus, inflammatory biomarkers might be used to predict cancer severity and monitor the progression [28] .…”

Section: Disucssionmentioning

confidence: 99%

Transthyretin as a Novel Biomarker for Diagnosis of Hepatocellular Carcinoma in cirrhotic patients

Ibrahim

El-Raey

Fathy

et al. 2020

International Journal of Medical Arts

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Background: Hepatocellular carcinoma [HCC] is one of the leading causes of cancer-related deaths worldwide. A major problem with HCC surveillance is the lack of reliable biomarkers. Serum transthyretin [TTR] may be a sensitive marker for the diagnosis of patients with liver cell damage, liver cirrhosis or hepatocellular carcinoma. Aim of the work:This study aimed to evaluate the potentiality of serum transthyretin [TTR] as a novel biomarker for detection of HCC in cirrhotic patients. Patients and Methods: This Current study was conducted on 70 patients with chronic liver disease. Also, 20 healthy person matched for age and sex were included as a control group. Patients were classified into 2 groups [30 cirrhotic patients with newly diagnosed HCC & 40 cirrhotic patients without HCC]. Serum TTR levels were measured using enzyme linked immunosorbent assay technique. Results: Serum levels of TTR were significantly much lower in HCC patients when compared to cirrhotic patients without HCC or control group [p<0.0001]. Significant decrease of serum TTR in HCC patients, with portal vein invasion or nodal invasion than in HCC without vascular or nodal invasion. The diagnostic accuracy of TTR was higher than that of AFP regarding sensitivity [83.3%] and negative predictive value [81.4%] in diagnosis of HCC. Conclusion: detection of lower level of TTR alone or in combination with other validated markers may be potentially informative biomarker for detection of HCC among cirrhotic patients at early noninvasive stage where curative treatment can be applied.

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The pretreatment erythrocyte sedimentation rate predicts survival outcomes after surgery and adjuvant radiotherapy for extremity soft tissue sarcoma

Cited by 14 publications

References 35 publications

Meta-Analysis of Hematological Biomarkers as Reliable Indicators of Soft Tissue Sarcoma Prognosis

Meta-Analysis of Hematological Biomarkers as Reliable Indicators of Soft Tissue Sarcoma Prognosis

Factors associated with survival in diabetic patients with rhino-orbito-cerebral mucormycosis

Transthyretin as a Novel Biomarker for Diagnosis of Hepatocellular Carcinoma in cirrhotic patients

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