The pretreatment lymphocyte to monocyte ratio predicts clinical outcome for patients with hepatocellular carcinoma: A meta-analysis

Song, Wei; Tian, Chen; Wang, Kai; Zhang, Run-jin; Zou, Shubing

doi:10.1038/srep46601

Cited by 43 publications

(39 citation statements)

References 41 publications

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“…A meta‐analysis of HCC found that a high LMR is associated with increased overall survival and disease‐free survival after hepatic resection . The present study is the first to our knowledge to evaluate the significance of LMR in patients who underwent LT for HCC.…”

Section: Discussionsupporting

confidence: 53%

“…A meta-analysis of HCC found that a high LMR is associated with increased overall survival and Original article | 1609 disease-free survival after hepatic resection. (22) The present study is the first to our knowledge to evaluate the significance of LMR in patients who underwent LT for HCC. Unlike hepatic resection for HCC, a healthy donor is required, and there are few effective therapies for the recurrence of HCC after LDLT.…”

Section: Discussionmentioning

confidence: 88%

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Lymphocyte‐to‐Monocyte Ratio Is a Predictor of Survival After Liver Transplantation for Hepatocellular Carcinoma

et al. 2018

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Recent studies revealed that systemic inflammation was correlated with poorer prognosis in various cancers. We investigated the prognostic value of the lymphocyte-to-monocyte ratio (LMR) in patients who underwent living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). We retrospectively analyzed the records of 216 patients who underwent LDLT for HCC. Patients were divided into high (n = 126) and low (n = 90) LMR groups. Their clinicopathological parameters and survival times were compared. To determine the mechanisms of the change in the LMR, we performed immunohistochemical analyses of CD3 and CD68 expression. A low LMR was significantly associated with a high Model for End-Stage Liver Disease score; a high Child-Pugh score; elevation of alpha-fetoprotein, des-gamma-carboxyprothrombin, and neutrophil-to-lymphocyte ratio; larger tumor size; more tumors; and poorer prognosis. A low LMR was associated with poor prognosis and represented an independent prognostic factor, particularly among patients beyond the Milan criteria. The ratio of CD3-positive to CD68-positive cells was significantly lower in the low-LMR group. In conclusion, our results show that the LMR was an independent predictor of survival of patients with HCC beyond the Milan criteria who underwent LDLT. The LMR reflected the immune status of the tumor microenvironment.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 88%

Lymphocyte‐to‐Monocyte Ratio Is a Predictor of Survival After Liver Transplantation for Hepatocellular Carcinoma

et al. 2018

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“…Indeed, among patients with acute myocardial infarction, it has been shown that an increased NLR is a predictor of in-hospital mortality and morbidity [26], and impaired myocardial perfusion after percutaneous coronary angioplasty [27]. Similarly, LMR has been reported to be associated with adverse prognosis in multiple malignancies [22,28] and coronary artery disease [21,29].…”

Section: Discussionmentioning

confidence: 99%

The association of neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio with 3-month clinical outcome after mechanical thrombectomy following stroke

Lux

Alakbarzade

Bridge

et al. 2020

J Neuroinflammation

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Background and aim: Neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) are associated with clinical outcomes in malignancy, cardiovascular disease and stroke. Here we investigate their association with outcome after acute ischaemic stroke treated by mechanical thrombectomy (MT). Methods: Patients were selected using audit data for MT for acute anterior circulation ischaemic stroke at a UK centre from May 2016-July 2017. Clinical and laboratory data including neutrophil, lymphocyte and monocyte count tested before and 24 h after MT were collected. Poor functional outcome was defined as modified Rankin Scale (mRS) of 3-6 at 3 months. Multivariable logistic regression analyses were performed to explore the relationship of NLR and LMR with functional outcome. Results: One hundred twenty-one patients (mean age 66.4 ± 16.7, 52% female) were included. Higher NLR (adjusted OR 0.022, 95% CI, 0.009-0.34, p = 0.001) and lower LMR (adjusted OR − 0.093, 95% CI (− 0.175)−(− 0.012), p = 0.025) at 24-h post-MT were significantly associated with poorer functional outcome when controlling for age, baseline NIHSS score, infarct size, presence of good collateral supply, recanalisation and symptomatic intracranial haemorrhage on multivariate logistic regression. Admission NLR or LMR were not significant predictors of mRS at 3 months. The optimal cut-off values of NLR and LMR at 24-h post-MT that best discriminated poor outcome were 5.5 (80% sensitivity and 60% specificity) and 2.0 (80% sensitivity and 50% specificity), respectively on receiver operating characteristic curve analysis.Conclusion: NLR and LMR tested at 24 h after ictus or intervention may predict 3-month functional outcome.

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“…Neutrophils can contribute to chronic inflammation and promote tumor angiogenesis and growth by secreting specific molecules [46, 48]. A deficiency in or disruption of lymphocytes is involved in the SIR and promotion of malignancies [13, 47]. The NLR, calculated as the absolute neutrophil count divided by the absolute lymphocyte count, has often been investigated as a potential indicator in various tumors [49-51].…”

Section: Discussionmentioning

confidence: 99%

“…More recently, SIR-related biomarkers, such as C-reactive protein (CRP) [12], the lymphocyte-monocyte ratio (LMR) [13], and the platelet-lymphocyte ratio (PLR) [14], have been investigated as potential predictors in bladder cancer. The neutrophil-lymphocyte ratio (NLR) has also been investigated as an economic and readily available predictor for bladder tumors in a few studies [15-19].…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Neutrophil-Lymphocyte Ratio as a Predictor in Bladder Cancer and Metastatic or Unresectable Urothelial Carcinoma Patients: a Pooled Analysis of Comparative Studies

Zhao

Wang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Emerging studies have shown that the neutrophil-lymphocyte ratio (NLR) is a potential predictor in various tumors. Our study was conducted to assess the prognostic value of the pretreatment NLR in bladder cancer and metastatic or unresectable urothelial carcinoma (mUC or uUC) patients up to July 2017. The correlation between the pretreatment NLR and pathological characteristics was also evaluated in bladder cancer patients. Methods: The hazard ratio (HR) and odds ratio (OR) with the 95% confidence interval (CI) were extracted or calculated from the included studies for further pooled analysis. A total of 21 studies were included in a pooled analysis. Results: The pooled results indicated that a high pretreatment NLR was associated with reduced overall survival (OS) (HR=1.27, 95% CI=1.12-1.43), relapse-free survival (RFS) (HR=1.41, 95% CI=1.23-1.60), progression-free survival (PFS) (HR=1.75, 95% CI=1.36-2.15), disease-specific survival (DSS) and cancer-specific survival (CSS) (HR=1.27, 95% CI=1.19-1.35) in the bladder cancer patients. Additionally, an elevated pretreatment NLR suggested a worse OS rate in the mUC or uUC patients (HR=1.63, 95% CI=1.34-1.91). The pooled ORs and 95% CIs showed that a high pretreatment NLR could be a risk indicator for certain pathological features, such as lymphovascular invasion, a positive margin status and advanced tumor stage. Conclusions: our results showed that a high pretreatment NLR predicted poor prognosis in bladder cancer, mUC and uUC patients.

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The pretreatment lymphocyte to monocyte ratio predicts clinical outcome for patients with hepatocellular carcinoma: A meta-analysis

Cited by 43 publications

References 41 publications

Lymphocyte‐to‐Monocyte Ratio Is a Predictor of Survival After Liver Transplantation for Hepatocellular Carcinoma

Lymphocyte‐to‐Monocyte Ratio Is a Predictor of Survival After Liver Transplantation for Hepatocellular Carcinoma

The association of neutrophil-lymphocyte ratio and lymphocyte-monocyte ratio with 3-month clinical outcome after mechanical thrombectomy following stroke

Pretreatment Neutrophil-Lymphocyte Ratio as a Predictor in Bladder Cancer and Metastatic or Unresectable Urothelial Carcinoma Patients: a Pooled Analysis of Comparative Studies

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