The Pretreatment Principle in Renal Transplantation as Illustrated by Thoracic Duct Drainage

Starzl, Thomas E.; Weil, Richard; Koep, Lawrence J.

doi:10.1007/978-1-4684-4826-9_51

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“…The response can be reduced into a more easily deletable range by pretreatment with many immunosuppressive modalities. 12,13 This was accomplished in our patients with a polyclonal antithymocyte globulin. 7 Other antilymphoid antibody preparations are expected to be effective, including the humanised monoclonal antibody, alemtuzumab, used for cadaver-kidney recipients by Calne and colleagues 14 as part of a steroid-sparing regimen based on ciclosporin.…”

Section: Discussionmentioning

confidence: 99%

Tolerogenic immunosuppression for organ transplantation

et al. 2003

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SummaryBackground-Insight into the mechanisms of organ engraftment and acquired tolerance has made it possible to facilitate these mechanisms, by tailoring the timing and dosage of immunosuppression in accordance with two therapeutic principles: recipient pretreatment, and minimum use of post-transplant immunosuppression. We aimed to apply these principles in recipients of renal and extrarenal organ transplants.

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