The prevalence and antimicrobial resistance profiles of bacterial isolates from meat and meat products in Ethiopia: a systematic review and meta-analysis

Zelalem, Andarge; Sisay, Mekonnen; Vipham, Jessie L.; Abegaz, Kebede; Kebede, Ameha; Terefe, Yitagele

doi:10.1186/s40550-019-0071-z

Cited by 36 publications

(34 citation statements)

References 44 publications

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“…The E. coli O157 occurrence of 6.3% in beef was comparable with the national prevalence estimate (6%) in Ethiopia (Zelalem et al, 2019). This percentage was higher than in studies in other countries that reported 2.2% in Nigeria (Tafida et al, 2014), 0.3% in European Union (EFSA, 2013), 0.8% in the United States (Hill et al, 2011), and 1.7% in Australia (Kiermeier et al, 2011).…”

Section: Discussionsupporting

confidence: 72%

Occurrence, Molecular Characteristics, and Antimicrobial Resistance ofEscherichia coliO157 in Cattle, Beef, and Humans in Bishoftu Town, Central Ethiopia

Gutema

Rasschaert²,

Agga

et al. 2021

Foodborne Pathogens and Disease

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Escherichia coli O157 is a Shiga toxin-producing E. coli causing disease in humans. Cattle are the primary reservoir of the pathogen. Information regarding the contribution of cattle to diarrheal illnesses in humans through consumption of contaminated beef is scarce in Ethiopia. We collected samples from 240 cattle, 127 beef, and 216 diarrheic patients in Bishoftu town in Ethiopia to assess the occurrence and determine the virulence genes, genetic relatedness, and antimicrobial resistance of E. coli O157. E. coli O157 was detected in 7.1% of the rectal content samples from cattle in slaughterhouses, in 6.3% (n = 127) of the beef samples, and in 2.8% of the diarrheic patients' stool samples. All isolates were positive for eae gene, 24 (77%) of them were positive for stx2 gene (21 stx2c and 3 stx2a), whereas stx1 gene was not detected. Molecular typing grouped the isolates into eight pulsed-field gel electrophoresis pulsotypes with three pulsotypes containing isolates from all three sources, one pulsotype containing one isolate from human origin and one isolate from beef. The remaining four pulsotypes contained isolates unique either to beef or to humans. With the exception of 1 multidrugresistant isolate from beef, which was resistant to 8 antimicrobial drugs, the remaining 30 isolates were susceptible to the 14 antimicrobials tested. In conclusion, the finding of genetically similar isolates in cattle, beef, and humans may indicate a potential transmission of E. coli O157 from cattle to humans through beef. However, more robust studies are required to confirm this epidemiological link.

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Section: Discussionsupporting

confidence: 72%

Occurrence, Molecular Characteristics, and Antimicrobial Resistance ofEscherichia coliO157 in Cattle, Beef, and Humans in Bishoftu Town, Central Ethiopia

Gutema

Rasschaert²,

Agga

et al. 2021

Foodborne Pathogens and Disease

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“…In a systemic and meta-analysis study done in foods of animal origin (beef, milk, mutton, chevon, and chicken) and environmental swabs in Ethiopia, the estimated pooled prevalence of E. coli was 15% [ 39 ] which is less than that reported in the present study. On the contrary, meta-analysis study done on E. coli O157 : H7 found 4% prevalence in foods of animal origin [ 40 ] and 5% pooled prevalence of E. coli O157 : H7 [ 41 ]. This discrepancy may be due to difference in study subjects, and detection method, or true prevalence.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Escherichia coli in Under-Five Children with Diarrhea in Ethiopia: A Systematic Review and Meta-Analysis

Zenebe

Mitiku

Alem

2020

International Journal of Microbiology

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Diarrhea remains as a high health burden, especially to children in low-income countries including Ethiopia. Diarrheagenic Escherichia coli have been commonly associated as bacterial pathogens causing diarrheal disease among children. This systemic review and meta-analysis was intended to determine the pooled prevalence of Escherichia coli in under-five children with diarrhea in Ethiopia. A comprehensive search in PubMed, Google Scholar, ScienceDirect, ResearchGate, and Google search engine and manual searching were done for this systematic review and meta-analysis. The eligibility criteria for selecting studies were studies involving under-five children with diarrhea in Ethiopia, published articles, cross-sectional studies, and articles reported in English. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. The data analysis was done using STATA 16.0 software. Cochran’s Q-test and I2 statistics were used for the assessment of heterogeneity. The random-effect model was used to estimate the pooled prevalence of Escherichia coli. A total of 797 articles were initially retrieved, and finally, 11 studies met the eligibility criteria and were included in the final meta-analysis. The pooled prevalence of Escherichia coli was 25% (95% CI: 9, 41). The pooled prevalence was varied by region, detection method, and sample size. The high prevalence emphasizes that Escherichia coli is a potential pathogen in under-five children with diarrhea in Ethiopia.

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“…Bacteria are the causative agent of two-thirds of food-borne disease outbreaks though there have been around 250 different food-borne diseases [ 31 ]. From the biological hazards, bacterial pathogens are the most serious concern regarding the issues of meat safety to consumers [ 32 ]. Bacterial food-borne illnesses are among the most widely spread global public health problems in recent times [ 8 ].…”

Section: Food-borne Zoonotic Bacterial Pathogensmentioning

confidence: 99%

Review on Major Food-Borne Zoonotic Bacterial Pathogens

Abebe

Gugsa

Ahmed

2020

Journal of Tropical Medicine

346

203

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Food-borne microorganisms are major pathogens affecting food safety and cause human illness worldwide as a result of consumption of foodstuff, mainly animal products contaminated with vegetative pathogens or their toxins. Most of these microbes have zoonotic importance resulting in significant impact on both public health and economic sectors. Bacteria are the causative agents of two-thirds of human food-borne diseases worldwide with high burden in developing countries. Hence, the objectives of this review paper are to highlight the background of food-borne bacterial pathogens and to review common major food-borne zoonotic bacterial pathogens. Food animals are the major reservoirs of many food-borne zoonotic bacterial pathogens, and food products of animal origin are the main vehicles of transmission. Meat, dairy products, and eggs are the main ways by which people are exposed to zoonotic bacteria. S. aureus, Salmonella species, Campylobacter species, L. monocytogenes, and E. coli are the major zoonotic bacterial pathogens which are the causative agents of food-borne illness and death in the world associated with consumption of contaminated animal products. Production of toxins and structural virulent factors are responsible for the pathogenesis of these bacteria. These major zoonotic bacteria cause human infections which are characterized mainly by gastrointestinal symptoms including nausea, vomiting, diarrhea, abdominal cramps, and other agent-specific symptoms. Some bacteria may cause severe complications. Conventional (culturing), serological, and molecular techniques are important for detection of these common zoonotic bacteria and their toxins in food. Good hygiene, GMP, sanitation in operating procedures, and implementation of standardized HACCP and pasteurization procedures are effective methods for the control and prevention. Currently, the emergence of multidrug-resistant zoonotic bacteria associated with consumption of contaminated animal products is a great concern for the public health, and there should be coordinated surveillance and monitoring system for food-borne zoonotic bacterial pathogens particularly in developing countries including Ethiopia.

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The prevalence and antimicrobial resistance profiles of bacterial isolates from meat and meat products in Ethiopia: a systematic review and meta-analysis

Cited by 36 publications

References 44 publications

Occurrence, Molecular Characteristics, and Antimicrobial Resistance ofEscherichia coliO157 in Cattle, Beef, and Humans in Bishoftu Town, Central Ethiopia

Occurrence, Molecular Characteristics, and Antimicrobial Resistance ofEscherichia coliO157 in Cattle, Beef, and Humans in Bishoftu Town, Central Ethiopia

Prevalence of Escherichia coli in Under-Five Children with Diarrhea in Ethiopia: A Systematic Review and Meta-Analysis

Review on Major Food-Borne Zoonotic Bacterial Pathogens

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