The prevalence and associated factors of dysphagia in Parkinson's disease: A systematic review and meta-analysis

Gong, Siyuan; Gao, Yan; Liu, Jihong; Li, Jia; Tang, Xueqin; Ran, Qian; Tang, Rongzhu; Liao, Chunlian

doi:10.3389/fneur.2022.1000527

Cited by 20 publications

(10 citation statements)

References 102 publications

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“…The sample size calculation was based on a dysphagia prevalence of 36.9% in PD (95% CI: 30.7–43.6%) according to Gong et al 10 To determine the sample size, the statistical software G*power 3.1.2 was used, analyzing the difference between means with a 95% confidence interval, a significance level of 5%, a margin of error of 5, and an estimated standard deviation of 12.9, as per the prevalence value from the literature (36.9% with a 95% CI: 30.7–43.6%). 10 The resulting sample included 29 patients.…”

Section: Methodsmentioning

confidence: 99%

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Sensitivity and specificity of the EAT-10 and SDQ-DP in identifying the risk of dysphagia in Parkinson's disease

Ponsoni,

Costa,

Soares

et al. 2024

Arq Neuropsiquiatr

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Background The early identification of risk for dysphagia in patients with Parkinson's disease (PD) is essential for the prevention of nutritional and pulmonary complications. Objective To analyze the sensitivity and specificity of the Swallowing Disturbance Questionnaire (SDQ-PD) and the Eating Assessment Tool (EAT-10) in identifying dysphagia risk in patients with early and intermediate stages of PD. Methods Twenty-nine patients with PD participated in the study. EAT-10 and SDQ-PD questionnaires were applied, and a videofluoroscopic swallowing study. Dysphagia Outcome and Severity Scale (DOSS) was used to classify the presence and severity of dysphagia, and the Penetration-Aspiration Scale (PAS) was used to identify the presence of penetration/aspiration. In the statistical analysis, the sensitivity and specificity of the risk questionnaires were calculated, as well as positive predictive value, negative predictive value, and accuracy. Results EAT-10 to identify the risk of penetration/aspiration revealed a sensitivity of 71.42% and specificity of 45.45%; in the identification of the presence of dysphagia, the sensitivity was 47.61%, and the specificity was 12.5%. The SDQ-PD questionnaire for risk of penetration/aspiration demonstrated a sensitivity of 28.57%, and a specificity of 68.18%. In terms of identifying the presence of dysphagia, the sensitivity was 20%, while the specificity was 44.44%. Conclusion The SDQ-PD revealed low sensitivity and low specificity to identify the presence of dysphagia and/or penetration/aspiration in patients with early and intermediate stages of PD in this sample. Despite its low specificity, the EAT-10 exhibited good sensitivity in indicating the risk of penetration/aspiration.

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Section: Methodsmentioning

confidence: 99%

“…Respiratória standard deviation of 12.9, as per the prevalence value from the literature (36.9% with a 95% CI: 30.7-43.6%). 10 The resulting sample included 29 patients.…”

Section: Palavras-chavementioning

confidence: 99%

Sensitivity and specificity of the EAT-10 and SDQ-DP in identifying the risk of dysphagia in Parkinson's disease

Ponsoni,

Costa,

Soares

et al. 2024

Arq Neuropsiquiatr

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“…The term 'dyspepsia' refers to a symptom complex that originates from the gastroduodenal region. 20 These symptoms include discomfort or pain in the upper abdomen, epigastric fullness, bloating, early satiety, nausea, and/or vomiting, 21 which Dysphagia ≈ 35.6%-80% 11,12 Oropharyngeal Lower gut…”

Section: Upper Gastrointestinal Issues In Parkinson's Diseasementioning

confidence: 99%

“…9 The entire GI tract is affected in PD 7,10 and leads to a wide variety of issues, including oropharyngeal and upper-mid gut (stomach and small bowel) and lower gut (large bowel) problems (Figure 1). 1,[11][12][13][14][15][16][17][18] Oropharyngeal problems, such as sialorrhea and dysphagia, are prevalent in advanced PD and were recently reviewed elsewhere. 10,19 Gastric and bowel dysfunction are prevalent in early and later stages of PD, and manifest as heterogeneous upper and lower GI symptoms.…”

Section: Introductionmentioning

confidence: 99%

Gastrointestinal Dysfunction in Parkinson’s Disease: Neuro-Gastroenterology Perspectives on a Multifaceted Problem

Tan¹,

Chuah²,

Beh³

et al. 2023

JMD

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Patients with Parkinson’s disease (PD) face a multitude of gastrointestinal (GI) symptoms, including nausea, bloating, reduced bowel movements, and difficulties with defecation. These symptoms are common and may accumulate during the course of PD but are often under-recognized and challenging to manage. Objective testing can be burdensome to patients and does not correlate well with symptoms. Effective treatment options are limited. Evidence is often based on studies in the general population, and specific evidence in PD is scarce. Upper GI dysfunction may also interfere with the pharmacological treatment of PD motor symptoms, which poses significant management challenges. Several new less invasive assessment tools and novel treatment options have emerged in recent years. The current review provides an overview and a practical approach to recognizing and diagnosing common upper and lower GI problems in PD, e.g., dyspepsia, gastroparesis, small bowel dysfunction, chronic constipation, and defecatory dysfunction. Management aspects are discussed based on the latest evidence from the PD and general populations, with insights for future research pertaining to GI dysfunction in PD.

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“…Of the nearly one million people living with Parkinson's disease (PD) in the U.S., an estimated one in six will experience avoidable complications in the hospital often related to medication management, mobility, and dysphagia (Aminoff et al, 2011 ; Hassan et al, 2013 ; Zeldenrust et al, 2020 ). Dysphagia, or impaired swallowing, is a common PD symptom that can lead to serious problems for people with PD in the hospital, including aspiration pneumonia, increased mortality, and longer hospitals stays (Di Luca et al, 2021 ; Gong et al, 2022 ). PD medication adjustments that may seem insignificant can lead directly to dysphagia and indirectly to aspiration pneumonia (Lenka et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Dysphagia and aspiration during a Parkinson's hospitalization: a care partner's perspective and recommendations for improving standards of care

Brooks

2023

Front. Aging Neurosci.

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People with Parkinson's disease have a significantly increased incidence and risk of aspiration pneumonia when compared to those without. Aspiration pneumonia associated with dysphagia (swallowing issues), which is the leading cause of death among people with Parkinson's disease, accounting for 25% of Parkinson's deaths. There is relatively limited evidence of the most effective strategies to balance the competing needs of each Parkinson's patient as providers aim to prevent, diagnose, and manage dysphagia. Exacerbated, and in part caused, by the intricacies of dysphagia and Parkinson's disease, there is still limited understanding among hospital providers and the Parkinson's community regarding the most appropriate measures to prevent and manage dysphagia in Parkinson's disease. The Parkinson's Foundation Hospital Care Recommendations identified the prevention and management of dysphagia as a care standard necessary to eliminate harm and attain higher reliability in care. This article discusses key components of dysphagia management in the hospital, provides a case example to demonstrate the challenges that people with PD and their care partners experience in the hospital related to dysphagia, and offers recommendations on how to better manage dysphagia and involve care partners in PD hospital care.

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The prevalence and associated factors of dysphagia in Parkinson's disease: A systematic review and meta-analysis

Cited by 20 publications

References 102 publications

Sensitivity and specificity of the EAT-10 and SDQ-DP in identifying the risk of dysphagia in Parkinson's disease

Sensitivity and specificity of the EAT-10 and SDQ-DP in identifying the risk of dysphagia in Parkinson's disease

Gastrointestinal Dysfunction in Parkinson’s Disease: Neuro-Gastroenterology Perspectives on a Multifaceted Problem

Dysphagia and aspiration during a Parkinson's hospitalization: a care partner's perspective and recommendations for improving standards of care

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