The prevalence and clinical characteristics of restless legs syndrome in patients with iron deficiency anemia in Korea

Bae, Hyoeun; Kim, Keun Tae; Heo, Mi Hwa; Do, Young-Rok; Cho, Yong Won

doi:10.5664/jcsm.9230

Cited by 9 publications

(6 citation statements)

References 37 publications

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“…In this cross-sectional study of patients with non-dialysis CKD, we verified important associations of self-reported sleep with depression as well as HRQOL and had some major discoveries. First, the overall prevalence of sleep disturbance was 58%, meaning that more than half of In our study, distinctions in sleep among patients with non-dialysis CKD were explained largely by age, anemia, and glucocorticoid use, similar to the results reported in previous studies (19,(24)(25)(26). A large-scale study found that time-in-bed and total sleep time showed a U-shaped association with age, which further corroborated the reliability of our results (27).…”

Section: Discussionsupporting

confidence: 89%

Association among sleep, depression, and health-related quality of life in patients with non-dialysis chronic kidney disease during the coronavirus disease 2019 pandemic

Chen¹,

Li²,

Zhang³

et al. 2022

Ann Palliat Med

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Background: Sleep disturbance is well documented as a crucial element that impairs health. Depression and health-related quality of life (HRQOL), which on behalf of a patient's overall perception of emotional, physical and social well-being, are increasingly emphasized self-reported health outcomes especially during the coronavirus disease 2019 (COVID-19) pandemic. Among dialysis patients, sleep disturbance is associated with depression and poorer HRQOL. The study was designed to depict the prevalence of sleep disturbance, and to explore the association among sleep, depression, and HRQOL in patients with non-dialysis chronic kidney disease (CKD) during the COVID-19 pandemic.Methods: A total of 172 non-dialysis CKD patients enrolled in this cross-sectional study, with sociodemographic and clinical data recorded. Sleep, HRQOL, and depression were evaluated via the Pittsburgh Sleep Quality Index (PSQI), the Kidney Disease Quality of Life 36-Item Short-Form Survey (KDQOL-36), and the 9-item Patient Health Questionnaire (PHQ-9), respectively.Results: A total of 100 (58%) met the criteria for poor sleep. Good sleepers had strikingly disparate HRQOL and depression scores compared to poor sleepers. Sleep disorders were significantly associated with decreased HRQOL and increased depression in regression models adjusted or unadjusted for sociodemographic and clinical characteristics. Mediation analysis indicated depression was a significant mediator explaining 51% of the relationship between sleep status with physical component summary (PCS) and played a fully mediating role in the association between sleep and mental component summary (MCS).Conclusions: Our study suggested the high incidence of sleep disorders in patients with non-dialysis CKD during the COVID-19 pandemic, as well as the tight associations among sleep, depression, and HRQOL.Considering the negative influences of sleep and depression on HRQOL, appropriate screening and treatment for these treatable health-related domains are necessary for patients with non-dialysis CKD.

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Section: Discussionsupporting

confidence: 89%

Association among sleep, depression, and health-related quality of life in patients with non-dialysis chronic kidney disease during the coronavirus disease 2019 pandemic

Chen¹,

Li²,

Zhang³

et al. 2022

Ann Palliat Med

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“… 11 Although there was no significant family history of RLS in the patient, she had IDA, which is associated with increased prevalence and severity of RLS. 8 , 9 Also, it is possible that IDA leads to alteration of dopaminergic receptor profile and contributes to RLS. 11 Since the symptoms suggesting RLS began only after a few days of administration of olanzapine, and her IDA existed before her admission to the hospital, we suspected olanzapine to be the root cause for her RLS with IDA worsening the severity of the syndrome.…”

Section: Discussionmentioning

confidence: 99%

“… 5 , 7 Oftentimes, RLS with increased severity is reported in iron deficiency anemia (IDA) patients. 8 , 9 So far, literature mentions that RLS can be managed using α2δ ligands or low doses of dopaminergic drugs, with the treatment of existing comorbidities to prevent augmentation of the condition. 10 Olanzapine is a second-generation antipsychotic which can cause RLS due to its anti-dopaminergic action on the nervous system particularly the spinal cord, and existing literature on olanzapine-induced RLS has suggested managing this disorder by reducing the dose or replacing olanzapine with other drugs such as clonazepam, quetiapine, and aripiprazole.…”

Section: Introductionmentioning

confidence: 99%

Olanzapine-induced restless leg syndrome (Willis–Ekbom disease): A case report

Das

Prasad

Anand

et al. 2022

SAGE Open Medical Case Reports

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Restless leg syndrome, also known as Willis–Ekbom disease, is a neurological sensorimotor disorder accompanied by an irresistible urge to move the legs with a fluctuating course of symptoms. It is a common disorder affecting all ages, with existing comorbidities and positive family history being associated with increased prevalence. Herein, we present a case of a 51-year-old female diagnosed with the bipolar affective disorder who developed restless leg syndrome following the use of olanzapine. Olanzapine is a second-generation antipsychotic which can cause restless leg syndrome due to its anti-dopaminergic action on the nervous system, particularly the spinal cord. Existing literature on olanzapine-induced restless leg syndrome has suggested managing this disorder by reducing the dose or replacing olanzapine with other drugs such as clonazepam, quetiapine, and aripiprazole. In our case, olanzapine was not replaced with other medications as the patient showed a significant improvement in bipolar affective disorder symptoms using olanzapine. Instead, clonazepam was added to the treatment regimen which was scheduled to be taken before olanzapine.

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“…Additionally, emerging evidence has shown that PLMS are associated with other comorbidities, which may directly or indirectly increase the risk of CSVD (Figorilli et al, 2017; Huang et al, 2019; Lin et al, 2018). Research has revealed an association between PLMS and iron deficiency anaemia and end‐stage renal disease (Allen et al, 2013; Bae et al, 2021). We noticed increased creatinine levels in patients with CSVD with a greater PLMS index.…”

Section: Discussionmentioning

confidence: 99%

Association between periodic limb movements during sleep and neuroimaging features of cerebral small vessel disease: A preliminary cross‐sectional study

Ouyang

Wang

Liao

et al. 2022

Journal of Sleep Research

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Summary Evidence on the relationship between periodic limb movements during sleep (PLMS) and cerebral small vessel disease is lacking. This study aimed to assess the association between the PLMS index and the neuroimaging features of cerebral small vessel disease on magnetic resonance imaging. Consecutive patients diagnosed with cerebral small vessel disease were enrolled. Data on the clinical characteristics, polysomnography, and brain magnetic resonance imaging were collected. The Accubrain software was used to calculate automatically the volume of white matter hyperintensities, the number of lacunar infarctions, and cerebral microbleeds. The severity of white matter hyperintensities, enlarged basal ganglia perivascular spaces, and the total cerebral small vessel disease scores were also rated visually using semiquantitative scales. The severity of PLMS was measured using the PLMS index, and the patients were divided into two groups using an established cut‐off value of ≥15 per hour. Logistic regression was used to examine the association between PLMS and the neuroimaging features of cerebral small vessel disease. In total, 37 patients were included in the final analyses. The mean age was 66.49 ± 11.31 years, and 73.0% were males. The mean PLMS index was 19.30 ± 10.18. In univariate analyses, it was found that patients with cerebral small vessel disease with a PLMS index ≥15 had increased enlarged basal ganglia perivascular spaces (OR 6.136, 95%CI 1.101–34.214) and increased total cerebral small vessel disease scores (OR 6.0, 95%CI 1.253–28.742). Only the association between the PLMS index and the total cerebral small vessel disease burden score remained statistically significant after adjusting for age, sex, and the presence of moderate to severe obstructive sleep apnea syndrome. In conclusion, an elevated PLMS index is likely to be associated with a greater cerebral small vessel disease burden. PLMS might be a novel potential marker of cerebral small vessel disease.

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The prevalence and clinical characteristics of restless legs syndrome in patients with iron deficiency anemia in Korea

Cited by 9 publications

References 37 publications

Association among sleep, depression, and health-related quality of life in patients with non-dialysis chronic kidney disease during the coronavirus disease 2019 pandemic

Association among sleep, depression, and health-related quality of life in patients with non-dialysis chronic kidney disease during the coronavirus disease 2019 pandemic

Olanzapine-induced restless leg syndrome (Willis–Ekbom disease): A case report

Association between periodic limb movements during sleep and neuroimaging features of cerebral small vessel disease: A preliminary cross‐sectional study

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