The prevalence and clinical significance of loss of appetite in older patients with chronic kidney disease

Yıldız, Serkan; Heybeli, Cihan; Smıth, Lee; Soysal, Pınar; Kazancıoğlu, Rümeyza

doi:10.1007/s11255-023-03540-1

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…First, CKD patients often experience a loss of appetite, which can be attributed to abnormalities in taste and smell senses caused by uremia, as well as the impact of metabolite accumulation on the central nervous system. 36,37 Second, vomiting and nausea are prevalent among CKD patients, often caused by metabolite buildup and medication side effects. [38][39][40] Third, digestive complications, including diarrhea and constipation, frequently afflict CKD patients.…”

Section: Malnutritionmentioning

confidence: 99%

Involuntary Falls in Patients with Chronic Kidney Diseases on Nephrology Wards: Research Advances and Future Perspectives

Liao,

Wang,

Sui

et al. 2024

NRR

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Background: Nephrology nursing faces an inevitable challenge when it comes to falls. This study aims to review existing literature on falls in chronic kidney disease (CKD) patients and to discuss potential solutions. Methods: This review explores the characteristics and causes of falls in CKD patients, elucidate the underlying mechanisms, shares better nursing practices, and discusses both current prevention strategies as well as potential future interventions. Results: CKD patients often experience consciousness impairment and motor dysfunction due to factors such as muscle atrophy, nerve damage, malnutrition, anemia, fluid-electrolyte imbalances, hormonal disorders, and dialysis. Additionally, this study not only shares insights from nursing experience with these patients, but also reviews current evidence-based fall prevention strategies and proposes potential new interventions that could be tested in future research. Conclusion: CKD may increase the risk of involuntary falls in patients due to consciousness impairment and motor dysfunction. Advocating for a standardized expert consensus on fall risk assessment and comprehensive care for CKD patients would enhance the nursing framework in nephrology wards and help patients decrease their fall risk and elevate their quality of life.

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Section: Malnutritionmentioning

confidence: 99%

Involuntary Falls in Patients with Chronic Kidney Diseases on Nephrology Wards: Research Advances and Future Perspectives

Liao,

Wang,

Sui

et al. 2024

NRR

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“…Older people are more vulnerable to the effects of medicines with anticholinergic activity due to reduced renal function and hepatic clearance, comorbid diseases and decrease in cholinergic neurons and their receptors resulting in decreased transmission of acetylcholine within the central nervous system (CNS) 16 17. In addition, certain conditions that occur in old age increase the permeability of the BBB including diabetes, Parkinson’s disease and Alzheimer’s disease 14.…”

Section: Anticholinergic Burdenmentioning

confidence: 99%

Managing drugs with anticholinergic activity

Bishara

2023

DTB

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Over the past two decades, considerable data have emerged on an association between drugs with anticholinergic activity and serious adverse effects in older people. Well-recognised anticholinergic adverse effects include dry mouth, blurred vision, constipation and urinary retention. Of particular concern is the potential impact on cognitive function with several studies showing that long-term use of medicines with anticholinergic activity is associated with worsening of cognitive function, increased incidence of dementia and increased mortality. This article gives an overview of the evidence, discusses some of the tools used to identify high-risk drugs and highlights issues to consider when prescribing drugs with anticholinergic activity with a view to reducing potential risks in older people and those at highest risk of cognitive impairment.

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Clinical Factors and Biomarkers Associated with Depressive Disorders in Older Patients Affected by Chronic Kidney Disease (CKD): Does the Advanced Glycation End Products (AGEs)/RAGE (Receptor for AGEs) System Play Any Role?

Buoli,

Dozio,

Caldiroli

et al. 2024

Geriatrics

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Depressive disorders are highly prevalent among subjects suffering from chronic kidney disease (CKD). The aim of the present study is to evaluate clinical and biochemical factors associated with depressive disorders in a sample of older CKD patients, with a focus on advanced glycation end products (AGEs) and their soluble receptors (sRAGEs). A total of 115 older subjects affected by CKD (stages 3 to 5, not in dialysis) were selected for this study. These patients were divided into two groups according to the presence of depressive disorders defined by a score ≥ 10 on the 30-item Geriatric Depression Scale (GDS). The two groups were compared by independent sample t tests for continuous variables and χ2 tests for qualitative ones. Significant variables at univariate analyses were then inserted as predictors of a binary logistic regression model, with the presence or absence of depressive disorders as a dependent variable. The binary logistic regression model showed that patients with concomitant depressive disorders were more frequently of female gender (p < 0.01) and had lower MCP1 (p < 0.01) and AGE circulating levels (p < 0.01) than their counterparts. Depressive disorders in older CKD patients are more prevalent in women and seem to be inversely associated with systemic inflammation and circulating AGEs.

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The prevalence and clinical significance of loss of appetite in older patients with chronic kidney disease

Cited by 3 publications

References 32 publications

Involuntary Falls in Patients with Chronic Kidney Diseases on Nephrology Wards: Research Advances and Future Perspectives

Involuntary Falls in Patients with Chronic Kidney Diseases on Nephrology Wards: Research Advances and Future Perspectives

Managing drugs with anticholinergic activity

Clinical Factors and Biomarkers Associated with Depressive Disorders in Older Patients Affected by Chronic Kidney Disease (CKD): Does the Advanced Glycation End Products (AGEs)/RAGE (Receptor for AGEs) System Play Any Role?

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