The prevalence and genotype distribution of rotavirus A infection among children with acute gastroenteritis in Kunming, China

Abstract

The aim of this study was to determine the prevalence of rotavirus A (RVA) infections in children from Kunming, China, and the RVA genotypes present. A total of 16,311 children with acute gastroenteritis were recruited for the study, and 33.1 % (5,394/16,311) were RVA positive. Children under 24 months of age were more susceptible to RVA infection, with an infection rate of 87.4 % (4,712/5,394). The most prevalent genotype was G9P[8] (85/107, 79.4 %), which showed high sequence similarity to G9P[8] strains from other regions of China and neighbouring countries, but not to the licensed vaccine strain LLR. These findings should be useful for the prevention of RVA infections.Electronic supplementary materialThe online version of this article (doi:10.1007/s00705-016-3102-6) contains supplementary material, which is available to authorized users.

Molecular epidemiology of group A rotavirus in outpatient diarrhea infants and children in Chongqing, China, 2011‐2015

“…From 2011 to 2015, the most dramatic change observed was that the previously predominant strains, G3P[8] and G1P[8] were replaced by genotype G9P[8] in recent years, increasing from 6.31% in 2011 to 61.38% in 2014. The similar conclusion was derived from other cities, such as Beijing, Kunming . However, G9P[8] became as the dominant genotype in Chongqing (since 2013) later than in Beijing (since 2012), but earlier than in Kunming (since 2014).…”

“…The similar conclusion was derived from other cities, such as Beijing, 35 Kunming. 36,37 However, G9P [8] became as the dominant genotype in Chongqing (since 2013) later than in Beijing (since 2012), 35 but earlier than in Kunming (since 2014). In late 2014, G9P [8] became as the dominant genotype in neighboring country Myanmar.…”

Prevalence and clinical profile of rotavirus A infection among diarrhoeal children and phylogenetic analysis with vaccine strains in Chengdu, West China, 2009–2014

“…LLR proved to share low identity to domestic strains. A study in Kunming, China also found the amino acid sequence of dominant G9P[8] strains to be closely related to RotaTeq but showing a low degree of homology with LLR . A randomised, double‐blind, placebo‐controlled multicentre trial in healthy Chinese infants indicated that RotaTeq was efficacious against any severity and severe rotavirus gastroenteritis caused by any serotype and generally well‐tolerated .…”

“…The variation in detection rates between studies may be related to study period, patient inclusion/exclusion criteria, climate or economic status [6]. The main identified G and P genotypes of RVA were G1 and P [8] and G1P [8] was the most prevalent genotype from 2009 to 2013, except for 2 months in 2014, when the dominant genotype was G9P[8]similar to Kunming, China, where from February 2015 to January 2016 G9P [8] strains accounted for 79.4% of all RVA strains [3]. The distribution of G9 strains has increased worldwide in recent years, including Uganda [23], Turkey [24] and Cambodia [25].…”

Rotavirus A strains obtained from children with acute gastroenteritis in Mozambique, 2012-2013: G and P genotypes and phylogenetic analysis of VP7 and partial VP4 genes

“…No correlation between age group and genotype was observed in this study, although it has been reported previously [ 33 ]. In a study investigating the prevalence and genotype distribution of RVA among children with acute gastroenteritis in Kunming, China, genotype G2P[4] was observed in patients between 12 and 48 months of age [ 34 ]. However, here we observed the occurrence of G2P[4] below 12 months of age, and even below 5 months (Fig.…”