The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis

Bahekar, Amol; Singh, Sarabjeet; Saha, Sandeep; Molnár, J.; Arora, Rohit

doi:10.1016/j.ahj.2007.06.037

Cited by 608 publications

(524 citation statements)

References 31 publications

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“…A meta-analysis of longitudinal and cross-sectional studies recently demonstrated that patients with periodontitis are at a significantly elevated relative risk of developing cardiovascular disease (CVD) [2]. One possible explanation for this could be the spread of bacteria and bacterial products into the circulation, and in this respect DNA from oral bacteria has been found in atherosclerotic plaques [3].…”

Section: Introductionmentioning

confidence: 99%

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

et al. 2009

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a b s t r a c tThis study investigated the effect of mechanical infection control for periodontitis and periodontal surgery on the prevalence of well-established risk factors for atherosclerosis, and plasma levels of cytokines, antibodies against heat shock proteins and markers of systemic inflammation.Sixty-eight patients between 39 and 73 years of age with severe periodontitis who had been referred to four specialist periodontology clinics in Sweden were investigated. A fasting venous blood sample was taken at baseline and additional samples were collected after 3 and 12 months. A total of 54 patients underwent periodontal treatment.The periodontal treatment was successful, as pathogenic gingival pockets decreased significantly. Plasma glucose, lipids and markers of systemic inflammation were not significantly altered after 3 months. One year after the initial treatment, HDL-C concentrations were significantly increased ( 0.08 mmol/L) whereas LDL-C concentrations decreased ( 0.23 mmol/L). Haptoglobin concentrations were also lower. Interleukin-18 and interferon-␥ levels were also lower after 12 months (60 ng/L (−23%) and 11 ng/L (−97%) respectively). Treatment had no effect on plasma levels of IgA, IgG1, IgG2 antibodies against heat shock proteins.In conclusion, this study indicates that standard treatment for periodontal disease induces systemic changes in several biochemical markers that reflect the risk for atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

et al. 2009

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“…121,116,117 A recent meta-analysis of longitudinal and cross-sectional studies has demonstrated that patients with chronic periodontitis are at risk of developing cardiovascular disease. 122 Periodontal pathogens play an important role in immune/inflammatory mechanisms that contribute to this phenomenon. 123,39,124 Periodontal pathogens and their products have been shown to instigate atherosclerotic changes in human and animal studies.…”

Section: Evidence For Effects Of Periodontal Treatment On Parameters mentioning

confidence: 99%

Chronic Periodontitis as a Risk Marker for Systemic Diseases with Reference to Cardiometabolic Disorders: Common Pathways in their Progression

Soory

2010

Immunol Immunogenet Insights

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Periodontitis, an inflammatory condition of the supporting structures of teeth resulting from dental plaque biofilm attached to tooth surfaces is potentially an important nidus of systemic inflammation and its sequelae. Relevant risk markers common to periodontitis co-existing with coronary heart disease and diabetes mellitus play an important role in their pathogeneses and abate in response to treatment. An over-exuberant host-response to periodontal pathogen-mediated inflammation, triggers a cycle of events which is not dissimilar to an autoimmune response in a cohort of susceptible individuals. Some variation in documented findings regarding correlations with co-morbidities and periodontitis could be explained by the lack of uniformity in studies with regard to stipulation of periodontal inflammatory status in the context of risk factors examined. There are several genetic and environmental factors which influence the progression of inflammatory periodontitis in response to plaque biofilm, also relevant to associated cardiometabolic disorders in the same subject. Some common mechanisms in the pathogeneses of periodontitis and cardiometabolic disorders based on regulation of inflammation are addressed in this review. There is some evidence of an improved systemic inflammatory profile in response to periodontal treatment which emphasizes the importance of periodontal management for systemic health in relevant cases.

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“…The nature of the association is variable, but two recent systematic reviews have suggested that periodontal disease is a risk for coronary heart disease and an adverse pregnancy outcome. 1,2 If periodontal disease is a signifi cant risk factor for a variety of systemic conditions, it does raise the important question of whether failure to address poor oral health increases the risk of patients succumbing to the various conditions outlined in Table 1 and their sequelae. The converse argument can also apply -that is, what impact does improving oral health have on general health?…”

Section: Introductionmentioning

confidence: 99%

Is gum disease killing your patient?

Seymour

2009

Br Dent J

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The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis

Cited by 608 publications

References 31 publications

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis

Chronic Periodontitis as a Risk Marker for Systemic Diseases with Reference to Cardiometabolic Disorders: Common Pathways in their Progression

Is gum disease killing your patient?

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