The prevalence and risk factors of sarcopenia in rheumatoid arthritis patients: A systematic review and meta-regression analysis

Li, Tzu-Hao; Chang, Yu‐Sheng; Li, Youfu; Su, Chin-Fang; Tsai, Hung-Cheng; Tsao, Yen‐Po; Liao, Hsien‐Tzung; Chen, Ming‐Han; Chuang, Chih-Cheng; Yang, Ying-Ying; Tsai, Chang‐Youh

doi:10.1016/j.semarthrit.2020.10.002

Cited by 43 publications

(51 citation statements)

References 79 publications

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“…In this prospective cross-sectional study, the 31% prevalence of sarcopenia in RA patients was similar to previous reports (range 8-88%) included in a meta-analysis by Li, T-H et al 35 This variation in reported prevalence re ects the difference in ethnicities, criteria for diagnosis of sarcopenia, diagnostic modalities, disease duration, disease activity, as well as the functional status of each study population. We used the 2019 criteria for the diagnosis of sarcopenia, 33 while other studies used older criteria.…”

Section: Discussionsupporting

confidence: 88%

Prevalence and Risk factors for Sarcopenia in Thai Patients with Rheumatoid arthritis

Kieattisaksopon

Narongroeknawin

Muangpaisan

et al. 2022

Preprint

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Background Sarcopenia is characterized by loss of muscle mass and strength, and/or decreased physical performance leading to increased all-cause mortality. We studied the prevalence and risk factors for sarcopenia in patients with rheumatoid arthritis (RA) Method A prospective cross-sectional study of 182 adult patients with RA. Sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment. The body impedance analyzer was used to estimate body composition. Hand grip dynamometer and six-meter walk test were performed to evaluate muscle strength and physical performance, respectively. Results Number (26.4%) patients had sarcopenia. Sarcopenia was common in females, older age, lower body mass index (BMI), and poorer nutritional status. Advanced age [hazard ratio (HR) 1.07 (95% CI 1.02–1.11), p = 0.002], low BMI [HR (95% CI) 0.81 (0.72–0.90), p < 0.001], high disease activity [HR (95% CI) 1.64 (1.22–2.12), p = 0.045], and depression [HR (95% CI) 1.18 (1.01–1.37), p = 0.04] were independently associated with sarcopenia.Conclusion Sarcopenia was found to be common in Thai RA, and its independent risk factors are age, disease activity, BMI, and depression. Well-controlled disease activity may be beneficial for preventing or minimizing sarcopenia and improving patient outcomes.

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Section: Discussionsupporting

confidence: 88%

Prevalence and Risk factors for Sarcopenia in Thai Patients with Rheumatoid arthritis

Kieattisaksopon

Narongroeknawin

Muangpaisan

et al. 2022

Preprint

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“…Several studies have shown that joint damage and high disease activity are risk factors for low muscle mass in RA [6,20,22,23]. A systematic review with meta-regression analysis showed that disease duration, DAS28, Health Assessment Questionnaire (HAQ) score were associated with occurrence of sarcopenia in RA [24]. Studies using experimental murine models of arthritis have revealed a loss of muscle mass derived from active arthritis [25,26].…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Muscle Mass and Function in Patients with Long-Standing Rheumatoid Arthritis

Yun

Kim

et al. 2021

JCM

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Muscular dysfunction in rheumatoid arthritis (RA) can affect the quality of life and comorbidities. We enrolled 320 patients with RA, and evaluated their muscle mass, grip strength, and physical performance. Seven (2.2%) and 21 RA patients (6.6%) had sarcopenia, as defined by the European and Asian Working Group for Sarcopenia (EWGS and AWGS), respectively; 54 patients (16.9%) were determined to have low muscle mass with normal muscle function, as defined by the EWGS; 38 patients (11.9%) reported sarcopenia by SARC-F questionnaire. Male sex (odds ratio (OR) 140.65), low body mass index (BMI) (OR 0.41), and use of tumor necrosis factor (TNF) inhibitors (OR 4.84) were associated with a low muscle mass as defined by the EWGS, while male sex, old age, and low BMI were associated with sarcopenia as defined by the AWGS. Old age (OR 1.11), high BMI (OR 1.13), and a high Disease Activity Score 28 (OR 1.95) were associated with sarcopenia as reported on the SARC-F. Male, low BMI, and use of TNF inhibitors were associated with a low muscle mass, while male sex, old age, and low BMI were associated with sarcopenia in patients with long-standing RA.

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“…In contrast, the European Working Group on Sarcopenia in the Elderly (EWGSOP) showed a prevalence of up to 29% in elderly people in the regular community 26 . Previous studies showed that the prevalence of sarcopenia in RA patients was 29.6–43.3% 27 – 31 , which was significantly higher than normal people. Thus, in our study, the incidence of sarcopenia in female RA patients was 60.0%, which might indicated that sarcopenia were more frequent in women.…”

Section: Discussionmentioning

confidence: 85%

“…Ange Ngeuleu et al studied 123 RA patients and found that the occurrence of sarcopenia was associated with DAS28, ESR, bone erosion, increased cardiometabolic risk and HAQ 30 . Li et al found that disease duration influenced development of sarcopenia, DAS28 and HAQ predict occurrence 31 . In present study, female RA patients with sarcopenia were usually older, had a longer disease duration and lower BMI than those without sarcopenia, which was consistent with the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

Effect of sarcopenia and poor balance on vertebral spinal osteoporotic fracture in female rheumatoid arthritis

Zhang

Zong

et al. 2022

Sci Rep

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This study investigated the effect of poor balance and sarcopenia on vertebral spinal osteoporotic fracture (VOPF) in female rheumatoid arthritic (RA) patients. A total of 195 female RA and 126 normal subjects were enrolled, and the correlations between sarcopenia, poor balance and VOPF were analyzed. Furthermore, we explored the relationships between sarcopenia or poor balance with disease related indexes of female RA. Binary logistic regression analyses were performed to identify potential risk factors for VOPF in female RA. We found that female RA had an increased risk of sarcopenia, poor balance (Berg balance scale, BBS ≤ 40) and VOPF than controls (P < 0.0001). Female RA with VOPF were more likely to have poor balance and sarcopenia than those without VOPF (P < 0.0001–0.05). Meanwhile, female RA with sarcopenia and poor balance often had higher disease activity, more serious joint damage and worse joint function (P < 0.05) compared with those without sarcopenia and poor balance. Binary logistic regression analysis (LR backwald) revealed that age (OR = 1.112, 95% CI 1.065–1.160, P < 0.0001), OP (OR = 10.137, 95% CI 4.224–24.330, P < 0.0001) and GCs usage (OR = 3.532, 95% CI 1.427–8.741, P = 0.006) were risk factors, while SMI (OR = 0.386, 95% CI 0.243–0.614, P < 0.0001) and BBS (OR = 0.952, 95% CI 0.929–0.976, P < 0.0001) were protective factors for VOPF in female RA. Hence, sarcopenia and poor balance are associated with a higher risk for VOPF and are closely related to disease activity and joint structure damage of female RA.

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The prevalence and risk factors of sarcopenia in rheumatoid arthritis patients: A systematic review and meta-regression analysis

Cited by 43 publications

References 79 publications

Prevalence and Risk factors for Sarcopenia in Thai Patients with Rheumatoid arthritis

Prevalence and Risk factors for Sarcopenia in Thai Patients with Rheumatoid arthritis

The Assessment of Muscle Mass and Function in Patients with Long-Standing Rheumatoid Arthritis

Effect of sarcopenia and poor balance on vertebral spinal osteoporotic fracture in female rheumatoid arthritis

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