The prevalence and risk factors of dementia in the elderly population in a low socio-economic region of Izmir, Turkey

Keskįnoğlu, Pembe; Giray, Hatice; Pıçakçıefe, Metin; Bilgiç, Nurcan; Uçku, Reyhan

doi:10.1016/j.archger.2005.09.006

Cited by 40 publications

(32 citation statements)

References 15 publications

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“…The pathology affects the temporolimbic area first and then extends to parietal and frontal lobes with relatively preserved primary motor and primary sensory areas (Braak et al 1993). Even though many factors can influence its clinical presentation, including gender, education or socio-economical background, (Keskinoglu et al 2006), its diagnosis or treatment monitoring mainly depends on clinical interpretation. Therefore, there is a strong need to develop objective tools for management of this disease.…”

Section: Introductionmentioning

confidence: 99%

Sensory evoked and event related oscillations in Alzheimer’s disease: a short review

Yener¹,

Başar²

2010

Cogn Neurodyn

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Diagnosis and treatment of Alzheimer's disease (AD) depend on clinical evaluation and there is a strong need for an objective tool as a biomarker. Our group has investigated brain oscillatory responses in a small group of AD subjects. We found that the de novo (untreated) AD group differs from both the cholinergically-treated AD group and aged-matched healthy controls in theta and delta responses over left frontal-central areas after cognitive stimulation. On the contrary, the difference observed in AD groups upon a sensory visual stimulation includes response increase over primary or secondary visual sensorial areas compared to controls. These findings imply at least two different neural networks, depending on type of stimulation (i.e. cognitive or sensory). The default mode defined as activity in resting state in AD seems to be affected electrophysiologically. Coherences are also very valuable in observing the group differences, especially when a cognitive stimulus is applied. In healthy controls, higher coherence values are elicited after a cognitive stimulus than after a sensory task. Our findings support the notion of disconnectivity of cortico-cortical connections in AD. The differences in comparison of oscillatory responses upon sensory and cognitive stimulations and their role as a biomarker in AD await further investigation in series with a greater number of subjects.

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Section: Introductionmentioning

confidence: 99%

Sensory evoked and event related oscillations in Alzheimer’s disease: a short review

Yener¹,

Başar²

2010

Cogn Neurodyn

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“…4 From the previous study that traced patients with stroke during three months it was found that most patients have mild disability (57.2%), some have severe disability (18.6%), and a few have moderate disability (9.4%). 5 In addition, stroke also led to memory disturbance and dementia over 9.4 times compared with and without stroke, 6 memory disturbance between 20 -80 percentage, 7,8 and the incidence of dementia was 5-48 percentage. 3,4 Moreover, probability of recurrent stroke increased, 9,10 recurrent stroke was 33.3 percentage, 11 the mortality rate of dementia after stroking was three times compared with and without, 7 and the estimated cost of caring the dementia patients around the world is approximately 604,000 million US dollar.…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with post-stroke dementia: a systematic review and meta-analysis

et al. 2017

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This study aimed to evaluate the risk factors for prognostic of post-stroke dementia (PSD). A systematic review included case-control and/or cohort studies, we searched both published and unpublished literatures between 2000 to July 31, 2016. Two authors independently screened and selected research articles. If another one disagreed, the third author would be just along with his/her professionally. Moreover, Critical appraisal was measured by the quality (GRADE). Data collection was in the data extraction form. The Rev-Man 5.3 was used to estimate pooled data. The fixed-effect model will be used when the heterogeneity I² <50%, whereas the random-effects model will be used when the heterogeneity I²>50%. Result eight publications were pooled for measuring an association between risk factors and PSD by meta-analysis. There were 6 strongly PSD risk factors. The pooled relative ratio (RR) of atrial fibrillation was 1.68, previous stroke 1.59, myocardial infarction 1.40, hypertension 1.36, diabetes mellitus 1.25 and previous transient ischemic attack 1.25 respectively. Un-pooled data from 13 publications reported that the risk factors for dementia in stroke patients were i) demographic factors, ii) vascular risk factors, iii) stroke factors, iv) stroke complications, and v) abnormalities on brain imaging. Strongly risk factors associated with increasing PSD risk were atrial fibrillation, previous stroke, myocardial infarction, hypertension, diabetes mellitus, and previous transient ischemic attack. Further studies, strongly risk factors need to investigate and develop the risk score for the prediction of dementia in stroke patients.

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“…Meanwhile, the authors observed higher rate of the prevalence of dementia (33.5%) than those of general population. In a community-based study carried out by Keskinoglu et al (2006), the prevalence of dementia was found as 22.9%. As already known, the predictive value is affected by differences in disease prevalence.…”

Section: Discussionmentioning

confidence: 95%

Reliability and validity of revised Turkish version of Mini Mental State Examination (rMMSE‐T) in community‐dwelling educated and uneducated elderly

Keskįnoğlu

Uçku

Yener

et al. 2009

Int J Geriat Psychiatry

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The prevalence and risk factors of dementia in the elderly population in a low socio-economic region of Izmir, Turkey

Cited by 40 publications

References 15 publications

Sensory evoked and event related oscillations in Alzheimer’s disease: a short review

Sensory evoked and event related oscillations in Alzheimer’s disease: a short review

Risk factors associated with post-stroke dementia: a systematic review and meta-analysis

Reliability and validity of revised Turkish version of Mini Mental State Examination (rMMSE‐T) in community‐dwelling educated and uneducated elderly

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