The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease

Yan, Jing; Hou, Chengye; Liang, Ying

doi:10.2147/ndt.s137183

Cited by 22 publications

(19 citation statements)

References 22 publications

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“…Yan and colleagues, in a large cross-sectional study comparing young males with schizophrenia with general young males, found a significantly higher prevalence of NAFLD of up to 49.5% in the study group compared to 20.1% in the control group. They found the factors most correlated with NAFLD were triglyceride levels, BMI, medication combinations, drug dosage, and negative factor scores on the PANSS [ 37 ].…”

Section: Epidemiology and Natural Historymentioning

confidence: 99%

Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Soto-Angona

Anmella

Valdés-Florido

et al. 2020

BMC Med

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Background Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. Main text This review compares the demographic data on NAFLD and NASH among the global population and the psychiatric population, finding differences that suggest a higher incidence of this disease among the latter. It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. Finally, possible treatments, tailored approaches, and future research directions are suggested. Conclusion NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. The recognition of the prevalent comorbidity between NAFLD and mental disorders is required to inform clinical practice and develop novel interventions to prevent and treat these complex and interacting disorders.

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Section: Epidemiology and Natural Historymentioning

confidence: 99%

Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Soto-Angona

Anmella

Valdés-Florido

et al. 2020

BMC Med

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“…The study in Spain used fatty liver index to determine the presence of liver steatosis, which predicted fatty liver disease based on body mass index (BMI), waist circumference, and triglyceride and gamma-glutamyltransferase levels [ 30 ]. Yan et al conducted a cross-sectional study in Liaoning, China, showing that the prevalence of NAFLD was 49.5% in 202 young males with schizophrenia [ 21 ]. In the present study, male schizophrenia inpatients aged 50–59 years had the highest NAFLD prevalence of 29.78%, which was still lower than that in the Liaoning study.…”

Section: Discussionmentioning

confidence: 99%

“…Compared to western population, the lifestyle and genetic factors causing NAFLD were different in Chinese population [ 20 ]. A recent cross-sectional study found that the prevalence of NAFLD was 49.5% in young males with schizophrenia, [ 21 ] which highlighted the need for more attention to fatty liver disease in schizophrenia patients. However, this above study only included 202 cases of young male schizophrenia patients, without female and elder participants [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…A recent cross-sectional study found that the prevalence of NAFLD was 49.5% in young males with schizophrenia, [ 21 ] which highlighted the need for more attention to fatty liver disease in schizophrenia patients. However, this above study only included 202 cases of young male schizophrenia patients, without female and elder participants [ 21 ]. Furthermore, the prevalence of NAFLD has not been clearly described in patients with bipolar disorder and depressive disorder.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study

Yang

et al. 2021

Hepatol Int

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Background and Purpose Non-alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in China. However, the understanding of NAFLD prevalence among Chinese mental disorder inpatients remains insufficient. We aim to investigate the prevalence of NAFLD among mental disorder inpatients in Beijing, China. Methods In this observational study, we included 66,273 mental disorder inpatients between 2014 and 2018, including inpatients with schizophrenia, bipolar disorder, depressive disorder and other mental disorders. Data were obtained from electronic health records of 19 specialized psychiatric hospitals in Beijing. NAFLD was defined by ICD-10 code, excluding other causes of liver disease. We calculated the overall and annual prevalence rates of NAFLD from 2014 to 2018, and compared NAFLD prevalence between sexes, age groups, mental disorders types, antipsychotics use, and comorbidities. Multivariable logistic regression was used to examine risk factors associated with NAFLD. Subgroup analysis was performed in different mental disorder types. Results The prevalence of NAFLD was 17.63% (95% CI 17.34–17.92%) in mental disorder inpatients, increasing from 16.88% in 2014 to 19.07% in 2018. The NAFLD prevalence in participants with schizophrenia (22.44%) was higher than that in participants with bipolar disorder (17.89%), depressive disorder (12.62%), and other mental disorders (12.99%). Women had similar or even higher NAFLD prevalence than men after 50 years. Men, 50–59 years (aOR = 1.71), schizophrenia (aOR = 1.56), bipolar disorder (aOR = 1.47), antipsychotics use (aOR = 1.46), hypertension (aOR = 1.50), diabetes (aOR = 1.83), dyslipidemia (aOR = 2.50) were risk factors for NAFLD in mental disorder inpatients. Conclusion NAFLD was common among Chinese mental disorder inpatients, and increased over years. The prevalence of NAFLD was higher among men, old women, inpatients with schizophrenia, bipolar disorder, antipsychotics, hypertension, diabetes, and dyslipidemia. Fatty liver disease among mental disorder population warrants the attention of psychiatric specialists and health policy-makers.

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“…Some previous studies have been performed in other severe psychiatric disorders, mainly in schizophrenia. In a recent cross‐sectional study including 202 young males with schizophrenia, Yan et al observed a prevalence of NAFLD of 49.5% 24 . Using the fatty liver index in a sample of 205 drug‐naïve individuals with first episode of schizophrenia, Morlán‐Coarasa et al showed a prevalence of NAFLD of 7% 25 .…”

Section: Discussionmentioning

confidence: 99%

Non‐alcoholic fatty liver disease in a sample of individuals with bipolar disorders: results from the FACE‐BD cohort

Godin

Leboyer

Belzeaux

et al. 2020

Acta Psychiatr Scand

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ObjectiveNon‐Alcoholic fatty liver disease (NAFLD) is becoming the most common liver disease in Western populations. While obesity and metabolic abnormalities are highly frequent in bipolar disorders (BD), no studies have been performed to estimate the prevalence of NALFD in individuals with BD. The aim of our study is to estimate the prevalence of NAFLD and to identify the potential associated risk factors in a large sample of BD individuals.MethodsBetween 2009 and 2019, 1969 BD individuals from the FACE‐BD cohort were included. Individuals with liver diseases, Hepatitis B or C, and current alcohol use disorders were excluded from the analyses. A blood sample was drawn from participants. Screening of NAFLD was determined using fatty liver index (FLI). Individuals with FLI> 60 were considered as having NAFLD.ResultsThe prevalence of NAFDL in this sample was estimated at 28.4%. NAFLD was observed in 40% of men and 21% of women. NAFLD was independently associated with older age, male gender, sleep disturbances, and current use of atypical antipsychotics or anxiolytics. As expected, the prevalence of NALFD was also higher in individuals with overweight and in those with metabolic syndrome.ConclusionsThis study reinforces the view that individuals with BD are highly vulnerable to metabolic and cardiovascular diseases. The prevalence of NAFLD in individuals with BD was two times higher than the prevalence reported in the general population. The regular screening of the MetS in individuals with BD should be therefore complemented by the additional screening of NAFLD among these vulnerable individuals.

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The prevalence and risk factors of young male schizophrenics with non-alcoholic fatty liver disease

Cited by 22 publications

References 22 publications

Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Prevalence of nonalcoholic fatty liver disease in mental disorder inpatients in China: an observational study

Non‐alcoholic fatty liver disease in a sample of individuals with bipolar disorders: results from the FACE‐BD cohort

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