The prevalence and risk factors of vertebral fractures in Korea

Shin, Chan Soo; Kim, Min Joo; Shim, Sang Mi; Kim, Jin Taek; Yu, Sung Hoon; Koo, Bo Kyung; Cho, Hwa Young; Choi, Hyo Geun; Cho, Sun Wook; Kim, Sang Wan; Kim, Seong Yeon; Yang, Seung Ok; Cho, Nam H.

doi:10.1007/s00774-011-0300-x

Cited by 51 publications

(42 citation statements)

References 42 publications

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“…Table 4 shows the age-specific SPR for morphometric VFs in AS patients compared with the morphometric VFs expected in the Korean general population [16]. There was a significant increase in the risk of morphometric VFs among AS patients aged over 40 years (standardized Prevalence rate (SPR) = 3.3, 95% CI = 2.06 to 4.54).…”

Section: Resultsmentioning

confidence: 99%

“…When comparing the prevalence of radiographic morphometric VFs in AS patients with that in the Korean general population [16], all AS patients under 40 years of age were excluded because all members of the general population group were ≥40 years old. We applied the age-specific prevalence of morphometric VF in the Korean general population study to the age distribution of our AS cohort, and calculated an age-standardized prevalence ratio (SPR) and its 95% CI.…”

Section: Methodsmentioning

confidence: 99%

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Incidence and predictors of morphometric vertebral fractures in patients with ankylosing spondylitis

et al. 2014

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IntroductionAnkylosing spondylitis (AS) is associated with an increased incidence of vertebral fractures (VFs); however the actual incidence and predictors of morphometric VFs are unknown. The present study examined the incidence and predictors of new VFs in a large AS cohort.MethodsIn total, 298 AS patients who fulfilled the modified New York criteria were enrolled and spinal radiographs were evaluated biennially. Clinical and laboratory data and radiographic progression were assessed according to the Bath AS Disease Activity Index, erythrocyte sedimentation rate, C-reactive protein (CRP), and the Stoke AS spine score (SASSS). VF was defined according to the Genant criteria. The incidence of VFs at 2 and 4 years was evaluated using the Kaplan-Meier method. The age-specific standardized prevalence ratio (SPR) for AS patients in comparison with the general population was calculated.ResultsOf 298 patients, 31 (10.8%) had previous VFs at baseline. A total of 30 new VFs occurred in 26 patients over 4 years. The incidence of morphometric VFs was 4.7% at 2 years and 13.6% at 4 years. Multivariate logistic regression analysis showed that previous VFs at baseline and increased CRP levels at 2 years were predictors of new VFs (odds ratio (OR) =12.8, 95% confidence interval (CI) = 3.6-45.3 and OR = 5.4, 95% CI = 1.4–15.9). The age-specific specific standardized prevalence ratio of morphometric VFs in AS was 3.3 (95% CI 2.1–4.5).ConclusionsThe incidence of morphometric VFs increased in AS. Previous VFs and increased CRP levels predicted future VFs. Further studies are needed to identify the effects of treatment interventions on the prevention of new VFs.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Incidence and predictors of morphometric vertebral fractures in patients with ankylosing spondylitis

et al. 2014

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“…Vertebral fracture is one of the most common osteoporotic fractures; it is a major public health problem that affects millions of people worldwide [23]. In the Korean population, the standardized prevalence for vertebral fractures using the age distribution has been reported to be 12.6% in women and 8.8% in men [4]. …”

Section: Introductionmentioning

confidence: 99%

Validation of the ECOS-16 Questionnaire in Koreans with Osteoporosis

et al. 2016

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Study DesignProspective study.PurposeTo evaluate the reliability and validity of the adapted Korean version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (ECOS-16).Overview of LiteratureThe validity of the Korean version of ECOS-16 has not been completely demonstrated.MethodsTranslation/retranslation of the English version of ECOS-16, and full cross-cultural adaptation were performed. The Korean version of a visual analog scale measure of pain, and the Korean versions of ECOS-16 and of the previously validated short form-36 (SF-36) were mailed to 158 consecutive patients with osteoporosis. Factor analysis and reliability assessment using kappa statistics of agreement for each item, intraclass correlation coefficient, and Cronbach's α were done. Construct validity was evaluated by comparing responses to ECOS-16 with responses to SF-36 using Pearson's correlation coefficient.ResultsFactor analysis extracted three factors. All items had a kappa statistics of agreement >0.6. The ECOS-16 showed good test/re-test reliability (0.8469) and internal consistency of Cronbach's α (0.897). The Korean version of ECOS-16 showed significant correlation with SF-36 total scores and with single SF-36 domains scores.ConclusionsThe adapted Korean version of the ECOS-16 was successfully translated and showed acceptable measurement properties. It is considered suitable for outcome assessments in Korean patients with osteoporosis.

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“…(21) However, the majority of studies have found lower mean BMI in vertebral fracture cases or no independent association with BMI for vertebral fracture. (22)(23)(24)(25)(26) The subclinical nature of most vertebral fractures and the difficulty of accurately measuring thoracic spine BMD by dual-energy X-ray absorptiometry (DXA) present particular challenges to the evaluation of adiposity and obesity on vertebral BMD and fracture risk.…”

Section: Introductionmentioning

confidence: 99%

Obesity and fracture in men and women: An epidemiologic perspective

Nielson

Srikanth

Orwoll

2011

Journal of Bone and Mineral Research

220

137

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In Western societies, mean body weight has increased dramatically in older people, and a similar trend exists in Asia. Yet insufficient attention has been directed to the problem of osteoporotic fractures in the overweight and obese. Many, if not most, osteoporotic fractures occur in overweight or obese people, and obese men may be particularly susceptible. We discuss the potential implications of these findings, including the challenge of identifying individuals at highest risk, screening and treatment strategies, and future research directions. ß

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The prevalence and risk factors of vertebral fractures in Korea

Cited by 51 publications

References 42 publications

Incidence and predictors of morphometric vertebral fractures in patients with ankylosing spondylitis

Incidence and predictors of morphometric vertebral fractures in patients with ankylosing spondylitis

Validation of the ECOS-16 Questionnaire in Koreans with Osteoporosis

Obesity and fracture in men and women: An epidemiologic perspective

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