The Prevalence and Significance of Brunn’s Nests, Cystitis Cystica and Squamous Metaplasia in Normal Bladders

Wiener, Daniel P.; Koss, Leopold G.; Sablay, Bella; Freed, Selwyn Z.

doi:10.1016/s0022-5347(17)56384-3

Cited by 151 publications

(73 citation statements)

References 22 publications

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“…Similar changes have been reported with characteristic histological appearances by several investigators (1,3,7,11,13). They were considered the possible precancerous role of several nonneoplastic changes.…”

Section: Di̇scussi̇onsupporting

confidence: 84%

“…They pointed out the importance of the nonneoplastic formations in better understanding the pathology of tumours of the urinary bladder. Nonneoplastic form s believed to happen as reactions to chronic irritations, infalamation and existed in transitional epithelium in forms of hyperplasia, metaplasia and as proliferation in the mucosa (1,2,7,11,13). These types of malformations in cattle are generally caused by bracken fem (Pteridium aquilinum).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nonnoeoplastic Findings of the Urinary Bladder in Caitle and Water Buffalo in the Black Sea Region of Turkey

Yılmaz;ÖZKUL¹

1995

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Section: Di̇scussi̇onsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Nonnoeoplastic Findings of the Urinary Bladder in Caitle and Water Buffalo in the Black Sea Region of Turkey

Yılmaz;ÖZKUL¹

1995

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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“…Von Brunn's nests are the small nests of urothelium within the lamina propria that are commonly encountered in bladder trigone but are seen in the PUJ of 10% cases at autopsy [13]. Von Brunn's nests with central lumina lined by urothelium or columnar glands are designated ureteropyelitis cystica and ureteropyelitis glandularis, respectively.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Lesions Affecting the Renal Pelvis and Pelviureteric Junction: A 13-Year Retrospective Analysis

Kini

Basavaiah

Suresh

et al. 2016

JCDR

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“…In fact, non-HPV-associated p16 overexpression is well established in other tumor types, such as uterine and ovarian serous carcinomas and non-HPV-associated cervical adenocarcinomas. 26,62 The two patients in our study had histories of neurogenic bladder and prolonged catheterization with chronic urinary tract infections, which by themselves are well-established risk factors for the development of bladder squamous cell carcinoma. To our knowledge, this is the first report of HPVassociated bladder carcinoma arising in this setting.…”

Section: Discussionmentioning

confidence: 99%

Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection

et al. 2012

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Squamous cell carcinomas of the urinary bladder are rare in the Western world; the majority of cases are reported in countries endemic to Schistosoma parasitic infections. Unlike squamous tumors of the uterine cervix or oropharynx, the human papillomavirus (HPV) is not commonly associated with bladder squamous cell carcinomas. We report on two cases of HPV-positive urothelial carcinomas of the urinary bladder with extensive squamous differentiation showing the typical basaloid, poorly differentiated morphology of HPV-associated tumors. These occurred in patients with neurogenic bladders who had long-standing histories of selfcatheterization with tumors that tested positive for HPV by in situ hybridization. A retrospective review of our institutional database revealed four additional patients with bladder tumors showing squamous differentiation arising in the setting of neurogenic bladder. Review of these cases showed the more common welldifferentiated keratinizing appearance of squamous cell carcinomas of the bladder. These tumors showed only patchy positivity for p16 immunohistochemical stain (not the diffuse strong staining seen in HPV-positive tumors), and the one tested case was negative for HPV by in situ hybridization. HPV infection and neurogenic bladder have been independently associated with increased risk of developing carcinoma in the urinary bladder; however, this is the first report of squamous tumors arising in the setting of concurrent neurogenic bladder and HPV infection. The morphology of these tumors is similar to that of other high-risk HPV-associated squamous carcinomas with a basaloid, poorly differentiated appearance and little to no keratin formation. Modern Pathology (2012) 25, 1534-1542; doi:10.1038/modpathol.2012.112; published online 6 July 2012 Keywords: HPV; neurogenic bladder; squamous cell carcinoma; urothelial cancerThe human papillomavirus (HPV) has an important role as a human carcinogen, with an estimated 10% of cancers worldwide attributed to it. 1 HPV is a small circular double-stranded DNA virus with more than 100 different types described to date. 2 The potential of the virus to cause malignant or benign lesions dictates its classification into low-risk (6,11,40,42, and so on) or high-risk (16,18,31,33,45,51, and so on) types. The prototypical model for carcinogenesis is squamous cell carcinoma of the uterine cervix, in which nearly all such carcinomas are associated with HPV infection. 3,4 The oncogenic role of HPV is also well established for a subset of squamous cell carcinomas in the vulva, 5 penis, 6 anus, 7 and oropharynx. 8 The possible role of HPV infection in bladder tumors has not been completely elucidated as HPV detection rates vary widely from 0 to 100%, depending on the study. 9,10 An intriguing issue has been the possible association of the virus with bladder squamous cell carcinoma. The few published studies 11-14 on this relationship have shown a low frequency of HPV detection, implying that HPV is not likely to have a major role in the development of bladd...

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The Prevalence and Significance of Brunn’s Nests, Cystitis Cystica and Squamous Metaplasia in Normal Bladders

Cited by 151 publications

References 22 publications

Nonnoeoplastic Findings of the Urinary Bladder in Caitle and Water Buffalo in the Black Sea Region of Turkey

Nonnoeoplastic Findings of the Urinary Bladder in Caitle and Water Buffalo in the Black Sea Region of Turkey

Spectrum of Lesions Affecting the Renal Pelvis and Pelviureteric Junction: A 13-Year Retrospective Analysis

Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection

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