The Prevalence and Significance of <i>Staphylococcus aureus</i> in Patients with Non–Cystic Fibrosis Bronchiectasis

Metersky, Mark L.; Aksamit, Timothy R.; Barker, Alan F.; Choate, Radmila; Daley, Charles L.; Daniels, M. Leigh Anne; DiMango, Angela; Eden, Edward; Griffith, David E.; Johnson, Margaret M.; Knowles, Michael R.; O’Donnell, Anne E.; Olivier, Kenneth N.; Salathé, Matthias; Thomashow, Byron; Tino, Gregory; Turino, Gerard M.; Winthrop, Kevin; Mannino, David M.

doi:10.1513/annalsats.201706-426oc

Cited by 41 publications

(26 citation statements)

References 18 publications

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“…The prevalence rate of S. aureus in human pus samples was 38% in the present study. This is in line with a previous study [ 38 ], which isolated S. aureus in 11.3% of patients from sputum specimens. The wide range in the reported prevalence of S. aureus in meat, milk products, and human samples among local and global studies may be attributed to differences in the hygienic measures implemented during food processing and manufacturing in the region of the study.…”

Section: Discussionsupporting

confidence: 93%

Prevalence and Characterization of Coagulase Positive Staphylococci from Food Products and Human Specimens in Egypt

Abdeen

Mousa

Abdelsalam³

et al. 2021

Antibiotics

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Methicillin-resistant Staphylococcus aureus (MRSA) strains have veterinary and public health importance as they are responsible for a wide range of difficult to treat infections and food poisoning. Two hundred samples (50 samples each of minced meat, beef luncheon, Karish cheese, and human samples (pus swab from open wounds)) were cultured, and MRSA strains were identified using disk diffusion tests and mecA gene-based PCR. A total of 35% (70/200) of the examined samples were confirmed as coagulase-positive S. aureus in minced meat (46%), beef luncheon (44%), Karish cheese (44%), and human samples (22%). The MRSA strains showed resistance to amoxicillin (91.4%), penicillin (97.1%), cefoxitin (85.7%), cephradine (82.9%), tetracycline (57.2%), and erythromycin (52.8%). More than half of the tested S. aureus isolates harbored the mecA gene. The sequence analysis of the mecA gene from the minced meat, Karish cheese, and human samples revealed high genetic similarities between the S. aureus isolates from these sources. In conclusion, our findings indicate a risk for the transmission of the mecA gene of S. aureus across the food chain between humans and animal food products. Further studies should focus on finding additional epidemiological aspects of the MRSA strains in food chain.

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Section: Discussionsupporting

confidence: 93%

Prevalence and Characterization of Coagulase Positive Staphylococci from Food Products and Human Specimens in Egypt

Abdeen

Mousa

Abdelsalam³

et al. 2021

Antibiotics

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“…The presence of other bacteria may also cause an accelerated clinical deterioration; however, the real impact of such infections has yet to be fully determined 60 . For example, a recent study using a large American database showed that the identification of methicillin-sensitive Staphylococcus aureus does not appear to be an independent risk factor for severe disease in bronchiectasis patients 61 …”

Section: Follow-up and Monitoringmentioning

confidence: 99%

Brazilian consensus on non-cystic fibrosis bronchiectasis

et al. 2019

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Bronchiectasis is a condition that has been increasingly diagnosed by chest HRCT. In the literature, bronchiectasis is divided into bronchiectasis secondary to cystic fibrosis and bronchiectasis not associated with cystic fibrosis, which is termed non-cystic fibrosis bronchiectasis. Many causes can lead to the development of bronchiectasis, and patients usually have chronic airway symptoms, recurrent infections, and CT abnormalities consistent with the condition. The first international guideline on the diagnosis and treatment of non-cystic fibrosis bronchiectasis was published in 2010. In Brazil, this is the first review document aimed at systematizing the knowledge that has been accumulated on the subject to date. Because there is insufficient evidence on which to base recommendations for various treatment topics, here the decision was made to prepare an expert consensus document. The Brazilian Thoracic Association Committee on Respiratory Infections summoned 10 pulmonologists with expertise in bronchiectasis in Brazil to conduct a critical assessment of the available scientific evidence and international guidelines, as well as to identify aspects that are relevant to the understanding of the heterogeneity of bronchiectasis and to its diagnostic and therapeutic management. Five broad topics were established (pathophysiology, diagnosis, monitoring of stable patients, treatment of stable patients, and management of exacerbations). After this subdivision, the topics were distributed among the authors, who conducted a nonsystematic review of the literature, giving priority to major publications in the specific areas, including original articles, review articles, and systematic reviews. The authors reviewed and commented on all topics, producing a single final document that was approved by consensus.

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“…Interestingly, S aureus was not associated with severe disease in this cohort. 24 Another study reported 17 cases of S aureus (6 being MRSA) in 233 cases of bronchiectasis, for rates of 7.3% (2.6% MRSA) in Spain. 25 Our reported rate of MRSA and Pseudomonas in bronchiectasis were 4% and 12.1%, respectively, and mortality was 3%.…”

Section: Discussionmentioning

confidence: 99%

Risk Factor Evaluation for Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa in Community-Acquired Pneumonia

Lewis

2020

Ann Pharmacother

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Background: The 2019 community-acquired pneumonia guidelines recommend using recent respiratory cultures and locally validated epidemiology plus risk factor assessment to determine empirical coverage of methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Objective: To develop a methodology for evaluating local epidemiology and validating local risk factors for P aeruginosa and MRSA. Methods: This multicenter, retrospective cohort evaluated adult patients admitted for pneumonia. Risk factors for MRSA and P aeruginosa were evaluated using multivariable logistic regression and reported as adjusted odds ratios (aORs). Results: There were 10 723 cases evaluated. Lung abscess/empyema had the highest odds associated with MRSA (aOR = 4.24; P < 0.0001), followed by influenza (aOR = 2.34; P = 0.01), end-stage renal disease (ESRD; aOR = 2.09; P = 0.006), illicit substance use (aOR = 1.7; P = 0.007), and chronic obstructive pulmonary disease (COPD; aOR = 1.26; P = 0.04). For P aeruginosa, the highest odds were in bronchiectasis (aOR = 6.13; P < 0.0001), lung abscess/empyema (aOR = 3.36; P = 0.005), and COPD (aOR = 1.84; P < 0.0001). Isolated COPD without other risk factors did not pose an increased risk of either organism. Conclusion and Relevance: Influenza, ESRD, lung abscess/empyema, and illicit substance use were local risk factors for MRSA. Bronchiectasis and lung abscess/empyema were risk factors for Pseudomonas. COPD was associated with MRSA and Pseudomonas. However, isolated COPD had similar rates of MRSA and Pseudomonas pneumonia compared with the total population. This study established a feasible methodology for evaluating local risk factors.

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The Prevalence and Significance of Staphylococcus aureus in Patients with Non–Cystic Fibrosis Bronchiectasis

Abstract: Staphylococcus aureus does not appear to be an independent risk factor for severe disease in patients with bronchiectasis enrolled in the Bronchiectasis Research Registry.

Cited by 41 publications

References 18 publications

Prevalence and Characterization of Coagulase Positive Staphylococci from Food Products and Human Specimens in Egypt

Prevalence and Characterization of Coagulase Positive Staphylococci from Food Products and Human Specimens in Egypt

Brazilian consensus on non-cystic fibrosis bronchiectasis

Risk Factor Evaluation for Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa in Community-Acquired Pneumonia

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