The prevalence and treatment gap of epilepsy in Tbilisi, Georgia

Lomidze, Giorgi; Kasradze, Sofia; Kvernadze, David; Okujava, N.; Toidze, Otar; Boer, Hanneke M. de; Dua, Tarun; Sander, Josemir W.

doi:10.1016/j.eplepsyres.2011.08.021

Cited by 28 publications

(23 citation statements)

References 16 publications

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“…These factors are likely to play a major role in the epilepsy treatment gap, which in some areas of the European Region has been estimated to be as high as 90% . Although comparative data on the extent of the treatment gap in different European countries are not available, a recent door‐to‐door survey of >10,000 inhabitants of Tbilisi, the capital of Georgia, found that about two thirds of the people with active epilepsy had not received appropriate AED treatment in the month prior to the survey . The authors' conclusions that ensuring consistent supply of AEDs at affordable prices should be a priority are fully supported by the results of our study.…”

Section: Discussionsupporting

confidence: 74%

Availability of antiepileptic drugs across Europe

et al. 2015

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SUMMARYEurope consists of 53 countries with widely different economic conditions and different political, educational, and health care systems. This study was aimed at determining the availability of antiepileptic drugs (AEDs) across Europe. An electronic questionnaire was submitted to all 43 European chapters of the International League Against Epilepsy (ILAE). Outcome measures were availability of older, newer, and newest AEDs, generic products, indications, reimbursement rules, and reasons for lack of availability of AEDs. Countries were divided according to economic status as defined by the World Bank. Thirty-four chapters (79%) provided data. There were large differences in AED availability across countries, especially between high-income countries and the other countries. The newest AEDs were not available in any of the 12 nonhigh-income countries. Availability was higher in countries with public reimbursement systems. Reimbursement policies ranged from full reimbursement for all AEDs to complete lack of reimbursement. Main hurdles for poor access to AEDs included lack of regulatory approval, high prices and reimbursement restrictions. The availability of AEDs differs across European countries, with many hurdles hampering access to epilepsy medicines, particularly to new medications. These findings raise major concerns on the quality of epilepsy care in many countries.

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Section: Discussionsupporting

confidence: 74%

Availability of antiepileptic drugs across Europe

et al. 2015

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“…When applying results to the situation in Georgia, with a prevalence of epilepsy 8.8/1000, we can consider that about 40,000 epilepsy patients could reside throughout the country [21] with about one-third of these being pharmacoresistant. Taking into consideration the rate of cases with unilateral HS in our study cohort, one would expect 400-1600 individuals being eligible for surgical treatment without the need for invasive studies.…”

Section: Discussionmentioning

confidence: 98%

Perspectives of epilepsy surgery in resource-poor countries: a study in Georgia

Kasradze¹,

Alkhidze

Lomidze³

et al. 2015

Acta Neurochir

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“…[22] Also, studies conducted in Africa found that epilepsy prevalence in ages 20-24 and 25-29 varied from 9.86/1000 to 7.18/1000 in Benin and in Kenya it was 4.0/1000 and 3.4/1000 (in males and females, respectively) in those aged 18-28. [19][20][21][22][23] This variability in prevalence rates may be due to socio-cultural, socioeconomic and geographical specifications and differences in study design, case detection techniques and inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

“…[20] For example, a study of the prevalence of epilepsy in Georgia, near the northeast border with Turkey, reported a rate of 8.1/1000 for the age range 21-40, higher than our rate among young adults. [21] Guekht A et al reported the prevalence of epilepsy in the Russian Federation, another neighboring country, was 3.9 per 1000 in the age range 14-29 and 3.5 per 1000 in the age range 30-39. [22] Also, studies conducted in Africa found that epilepsy prevalence in ages 20-24 and 25-29 varied from 9.86/1000 to 7.18/1000 in Benin and in Kenya it was 4.0/1000 and 3.4/1000 (in males and females, respectively) in those aged 18-28.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of epilepsy in the university students representing a young adult population with normal intelligence

Huseyinoglu¹,

Palanci²,

Güneş³

et al. 2014

Epilepsi

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Amaç: Epilepsi, dünya üzerinde yaklaşık 69 milyon kişiyi etkileyen en yaygın nörolojik hastalıklardan birisidir. Özellikle genç erişkinlerde epilepsinin sosyal ve özel hayat açısından getirdiği yük oldukça fazladır. Türkiye'nin doğusunda genç erişkin nüfus arasındaki epilepsi prevalansı ve risk faktörlerine dair yapılmış bir araştırma bulunmamaktadır. Bu nedenle, çalışmamızda Türkiye'nin doğusundaki normal zekaya sahip genç popülasyonun temsilcileri olarak Kafkas Üniversitesi öğrencilerinde epilepsi prevalansı ve risk faktörlerini araştırmayı amaçladık. Gereç ve Yöntem:Çalışmamızın örneklem grubunun sayısı en az 1135 öğrenci olarak hesaplandı. Dağıtılmış olan 2000 anketten 1829'u istatiksel analiz için kullanıldı. 43 muhtemel epilepsi olgusu ileri incelemeler için hastanemize davet edildiler. Sonuç olarak, yedi katılımcıya aktif epilepsi tanısı konuldu. Bulgular: 30 Aralık 2010 tarihi itibarıyla aktif epilepsinin nokta prevalansı 3.8/1000 olarak hesaplanmıştır. Epilepsi gelişiminde, febril nöbet öyküsü ve kafa travması istatistiksel olarak anlamlı risk faktörleri olarak saptanırken; cinsiyet, aile öyküsü, maddi gelir düzeyi, prematürite, doğum şekli ve akrabalık evliliği, epilepsi için istatistiksel olarak anlamlı risk faktörleri değildi.Sonuç: Türkiye'nin doğusundaki genç erişkin nüfusta epilepsi prevalans değerlerinin gelişmiş ülkelerdeki ile karşılaştırılabilir düzeyde olduğunu söyleyebiliriz. SummaryObjectives: Epilepsy is one of the most common neurological diseases and involves about 69 million patients worldwide. Especially in young adults, the social and private burden of epilepsy is high. The young adult population of Eastern Turkey has not been investigated with respect to the prevalence and risk factors of epilepsy. For these reasons we aimed to investigate the prevalence and some risk factors of active epilepsy in Kafkas University students as representatives the young adults of Eastern Turkey with normal intelligence. Methods:The sample size for our study of consisted of a minimum of 1135 students. A total of 2000 questionnaires were distributed among the students and 1829 were accepted for statistical analysis. 43 students were identified as possibly having epilepsy and invited for further investigation. As a result, 7 participants were determined to have active epilepsy. Results:The point prevalence of active defined epilepsy on December 30, 2010 was estimated to be 3.8/1000 for both sexes. The statistical analysis identified a history of febrile seizures and head trauma to be significant as risk factors for the development of epilepsy, while gender, family history of epilepsy, financial status, history of prematurity, cesarean or vaginal birth and parental consanguinity were not significant risk factors for epilepsy. Conclusion:We can conclude that the prevalence of epilepsy in young adults in the eastern region of Turkey is comparable to those in developed countries.

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The prevalence and treatment gap of epilepsy in Tbilisi, Georgia

Cited by 28 publications

References 16 publications

Availability of antiepileptic drugs across Europe

Availability of antiepileptic drugs across Europe

Perspectives of epilepsy surgery in resource-poor countries: a study in Georgia

Prevalence of epilepsy in the university students representing a young adult population with normal intelligence

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