The prevalence, characteristics and outcome of seizure in tuberculous meningitis

Abdulaziz, Ammar Taha Abdullah; Zhou, Dong

doi:10.1186/s42494-020-0010-x

Cited by 20 publications

(27 citation statements)

References 100 publications

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“…In this work, by analyzing HD and TB patients' plasma, we found that TB patients exhibit significantly higher concentrations of PGE2 as compared to HD (Figure 1). This observation is in agreement with other works reporting a greater amount of PGE2 in cerebrospinal fluid from meningeal TB patients compared to control individuals 19 . In turn, Mayer-Barber et al also observed higher concentrations of PGE2 in plasma from patients with mild TB as compared to HD and, additionally, extended this result taking into account the relationship with the production of another eicosanoid, such as LXA-4 10 .…”

Section: Discussionsupporting

confidence: 94%

Immunosuppressive role of PGE2 during human tuberculosis

Pellegrini

Tateosian

Morelli

et al. 2020

Preprint

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Prostaglandin E2 (PGE2), an active lipid compound derived from arachidonic acid, regulates different stages of the immune response of the host during several pathologies such as chronic infections or cancer. Manipulation of PGE2 levels was proposed as an approach for countering the Type I IFN signature of tuberculosis (TB), but very limited information exists about this pathway in patients with active TB. Here, we demonstrated that PGE2 exerts a potent immunosuppressive action during the immune response of the human host against M. tuberculosis. Thus, we showed that PGE2 inhibited both lymphoproliferation and cytokine production of proinflammatory cytokines, together with a significant reduction of the surface expression of several immunological receptors in human cells. However, PGE2 promoted the autophagic flux of antigen-stimulated monocytes, even in the presence of IFNα. In this way, the attenuation of inflammation and immunopathology caused by an excessive immune response emerges as an attractive therapeutic target. Together, our findings contribute to the knowledge of Mtb-resistance mediated by PGE2 and highlight the potential of this lipid mediator as a tool to improve anti-TB treatment.

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Section: Discussionsupporting

confidence: 94%

Immunosuppressive role of PGE2 during human tuberculosis

Pellegrini

Tateosian

Morelli

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…1). Our ndings are in line with other works reporting greater amounts of PGE2 in cerebrospinal uid from meningeal TB patients as compared to control individuals 24 . Moreover, Mayer-Barber et al also observed higher concentrations of PGE2 in plasma from patients with mild TB as compared to HD and even extended this result considering the ratio with LXA-4 production 6 .…”

Section: Discussionsupporting

confidence: 93%

PGE2 Displays Immunosuppressive Effects During Human Active Tuberculosis

Pellegrini

Martin

Morelli

et al. 2021

Preprint

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Prostaglandin E2 (PGE2), an active lipid compound derived from arachidonic acid, regulates different stages of the immune response of the host during several pathologies such as chronic infections or cancer. In fact, manipulation of PGE2 levels was proposed as an approach for countering the Type I IFN signature of tuberculosis (TB). However, very limited information regarding the PGE2 pathway in patients with active TB is currently available. In the present work, we demonstrated that PGE2 exerts a potent immunosuppressive action during the immune response of the human host against Mycobacterium tuberculosis (Mtb) infection. Actually, we showed that PGE2 significantly reduced lymphoproliferation, the production of proinflammatory cytokines, and the surface expression of several immunological receptors. On the other hand, PGE2 promoted autophagy in monocytes and neutrophils cultured with Mtb antigens. These results suggest that PGE2 might be attenuating the excessive inflammatory immune response caused by Mtb, emerging as an attractive therapeutic target. Taken together, our findings contribute to the knowledge of the role of PGE2 in the human host resistance to Mtb and highlight the potential of this lipid mediator as a tool to improve anti-TB treatment.

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“…The collected data indicated that one of the most important causes of seizures due to central nervous system infection is in ammation of the brain and nerve damage and the reactivation of glial cells (14).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Infected Woman with Tuberculous Meningitis: A Case Report

Nadershahbaz

Bidaki

Azimi

et al. 2020

Preprint

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Abstract Background: Several factors have been reported for COVID-19 disease. In addition, patients with COVID-19 are also susceptible to suffer from other problems. In this study, a case suffering from TB meningitis is reported to have developed COVID-19 disease, eventually showing symptoms of psychological disorders.Case presentation: A young Afghan woman was hospitalized with TB meningitis who did not respond to treatment. After a while, she was hospitalized again with diagnosis of COVID-19. The patient showed symptoms of postpartum depression and anxiety. She also had pseudoseizure attacks several times, so antidepressants and anti-anxiety medications were started for the patient In order to treat conversion disorder and panic disorders.Conclusion: Tuberculous meningitis, postpartum depression and other factors can increase the risk of COVID-19 infection leading to psychological disorders like conversion disorder in susceptible.

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The prevalence, characteristics and outcome of seizure in tuberculous meningitis

Cited by 20 publications

References 100 publications

Immunosuppressive role of PGE2 during human tuberculosis

Immunosuppressive role of PGE2 during human tuberculosis

PGE2 Displays Immunosuppressive Effects During Human Active Tuberculosis

COVID-19 Infected Woman with Tuberculous Meningitis: A Case Report

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