The prevalence of acne in adults 20 years and older

Collier, Christin N.; Harper, Julie; Cantrell, Wendy; Wang, Wenquan; Foster, K. Wade; Elewski, Boni E.

doi:10.1016/j.jaad.2007.06.045

Cited by 477 publications

(427 citation statements)

References 9 publications

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“…Essa pequena discrepância pode refletir aspectos culturais e geográficos da população estudada ou até aspectos metodológicos usados para definir esse corte. 7,10,11,15 GRÁFICO 1: Histograma etário das pacientes na data da consulta GRÁFICO 2: Histograma das idades de início dos sintomas GRÁFICO 3: Histograma do tempo de duração do quadro Algumas variáveis classicamente associadas às mulheres adultas com acne, como o uso de cosméti-cos, irregularidade menstrual e obesidade, não foram corroboradas por este estudo, demonstrando que as características topográficas da acne devem exercer melhor capacidade classificatória, quando ponderada a faixa etária envolvida. Da mesma forma, a história familiar não se mostrou elemento significativamente proeminente entre os grupos, o que não afasta a possibilidade de que ambas as formas tenham ascendên-cia familiar na mesma intensidade; entretanto, o viés de memória não pode ser desconsiderado nesse caso.…”

Section: Discussionunclassified

“…6 Quando avaliados os estudos observacionais, Collier et al identificaram prevalência de queixas de acne em 51% das mulheres entre 20 e 29 anos. 7 Goulden et al revisaram os registros de 200 pacientes com acne entre 25 e 55 anos, verificando que 76% eram mulheres e que, em 82% dos casos, havia persistência da acne da adolescência. Porém, Poli et al observaram apenas 59% com esse perfil e constataram que a prevalência só se reduzia significativamente após os 45 anos.…”

Section: Introductionunclassified

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Padrões clínicos de acne em mulheres de diferentes faixas etárias

Schmitt

Masuda

Miot

2009

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS: Acne é dermatose comum que acomete ambos os gêneros e todas as faixas etárias. Mulheres apresentam diferentes padrões clínicos da doença, além de frequente persistência da acne após a adolescência. OBJETIVO: Analisar características clínicas e epidemiológicas associadas às diferentes faixas etárias acometidas por acne feminina. MÉTODOS: Estudo transversal envolvendo mulheres com diagnóstico de acne, atendidas em ambulatório de dermatologia geral. Variáveis relacionadas à doença e às pacientes foram avaliadas com o emprego de questionário padronizado. RESULTADOS: Avaliaram-se 103 pacientes, cuja idade média na época da consulta foi 21,7 ± 7,3 anos. Definiram-se dois subgrupos com idade de corte de 21 anos e idades médias de 15,8 ± 2,3 e 28,0 ± 5,1 anos. Houve correlação entre a duração do quadro e a idade das pacientes na consulta (R = 0,7). Observaram-se diferenças entre os grupos nas frequências de uso de contraceptivo oral combinado (OR = 48,1), lesões no colo (OR = 11,6), lesões no dorso (OR = 0,2), predominância na topografia superior da face (OR = 0,1) e idade de início das lesões (OR = 1,8). No grupo de mulheres adultas, 80% relataram iní-cio do quadro antes dos 20 anos. CONCLUSÕES: Identificaram-se padrões clínicos cronológicos e topográficos que caracterizaram a acne feminina em diferentes faixas etárias, alertando para a importância da abordagem diagnóstica e terapêutica individualizada. Palavras-chave: Acne vulgar; Dermatologia; Estudos transversais; Hiperandrogenismo Abstract: BACKGROUND: Acne is a frequent skin disease that occurs in both sexes and all age-groups. Women present several clinical disease patterns; moreover, persistence after adolescence is common. OBJECTIVE: To analyze clinical and epidemiological characteristics associated with different age-groups affected by acne in women. METHODS: Cross-sectional study involving female patients diagnosed with acne, at a general dermatology outpatient clinic. Variables related to disease and patients were assessed through a standardized questionnaire. RESULTS: One hundred and three women were assessed. The average age of patients at the time of the consultation was 21.7 ± 7.3 years. Two groups were defined (cut-off age of 21 years), with means of 15.8 ± 2.3 and 28.0 ± 5.1 years. There was correlation between disease duration and current age (R=0.7). There were group differences among frequencies of covariables: combined oral contraceptive (OR=48.1), lesions located on upper chest (OR=11.6), lesions on upper dorsum (OR=0.2), predominance on upper half of face (OR=0.1) and age at disease onset (OR=1.8). Among adult women, 80% reported acne onset before 20 years of age. CONCLUSION: Chronologic and topographic patterns of female acne in different age-groups were defined, reinforcing the importance of an individualized diagnostic and therapeutic approach.

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Section: Discussionunclassified

Section: Introductionunclassified

Padrões clínicos de acne em mulheres de diferentes faixas etárias

Schmitt

Masuda

Miot

2009

An. Bras. Dermatol.

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“…Acne vulgaris affects up to 80% of Americans at some point in their lives. Though prevalent most frequently in adolescents, it may persist well into adulthood for some individuals [1]. The traditional paradigm of acne has generally consisted of four components, often presented in a sequential fashion.…”

Section: Introductionmentioning

confidence: 99%

“…The traditional paradigm of acne has generally consisted of four components, often presented in a sequential fashion. Androgen excess leads to increased [1] sebum production, along with [2] follicular hyperkeratinization which results in plugging of the follicle. This allows the bacterium [3] Propionibacterium acnes to grow within the follicle, eventually culminating in an [4] inflammatory cascade and clinically evident disease.…”

Section: Introductionmentioning

confidence: 99%

The Role of Propionibacterium acnes Biofilm in Acne Vulgaris

Linfante¹,

Allawh²,

Allen³

2017

J Clin Exp Dermatol Res

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Acne vulgaris is traditionally known as the result of excess sebum production, follicular hyper keratinization, infection with Propionibacterium acnes, and follicular inflammation. However, the role of P. acnes is gaining momentum as the primary impetus in the pathogenesis of acne vulgaris. The biofilm-forming ability of P. acnes in vitro and on indwelling medical appliances and catheters has been known for quite some time, but only in the last decade has the presence of P. acnes biofilm been observed within the pilosebaceous unit. Since that time, the genome of the microbe has been sequenced, and genes responsible for quorum sensing and biofilm formation have been confirmed. As a result of biofilm formation, the virulence of P. acnes is amplified. Biofilm-encapsulated P. acnes upregulates the production of lipases, resulting in the production of free fatty acids. Free fatty acids as well as the biofilm itself bind the Toll-like receptors TLR2 and TLR4, activating the innate immune system, culminating in a robust inflammatory response. Biofilms also appear to significantly contribute to antibiotic resistance. Acting as a physical barrier for antibiotics as well as a commune for bacteria to exchange antibiotic resistance genes, the biofilm plays an integral role as the major hurdle to treating acne vulgaris. Traditional antimicrobials have not shown much promise in disruption of the biofilm. Other approaches have been investigated utilizing a variety of novel topical compounds that act to prevent or disrupt the biofilm as a therapeutic modality. The role of biofilm in the pathogenesis of acne vulgaris has remained underappreciated, but with global antimicrobial resistance looming, further attention may be warranted.

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“…Although typically a disease of adolescence, acne is a common complaint in adult women, with a prevalence of up to 51% between 20 and 29 years of age [1,2]. Most of this cases begin in adolescence and seems to have no causal relationship with cosmetics, drugs or others occupational factors.…”

Section: Introductionmentioning

confidence: 99%

Persistence of Acne beyond 21 Year of Age in Adolescent Female Patients: A Retrospective Cohort

Fabri¹

2014

J Clin Exp Dermatol Res

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The prevalence of acne in adults 20 years and older

Cited by 477 publications

References 9 publications

Padrões clínicos de acne em mulheres de diferentes faixas etárias

Padrões clínicos de acne em mulheres de diferentes faixas etárias

The Role of Propionibacterium acnes Biofilm in Acne Vulgaris

Persistence of Acne beyond 21 Year of Age in Adolescent Female Patients: A Retrospective Cohort

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