The prevalence of adverse drug event-related admissions at a local hospital in Malaysia

Karuppannan, Mahmathi; Ting, Kang Nee; Ali, Salmiah Mohd; Thong, Wong Kok; Boardman, Helen F.

doi:10.4103/2045-080x.123224

Cited by 10 publications

(38 citation statements)

References 30 publications

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“…4 Medication errors may be committed by both inexperienced and experienced persons like doctors, pharmacists, dentists, patients, manufacturers and other healthcare providers. 5 The present study has been undertaken with the aim of finding out the incidences of medication errors in indoor patients of a tertiary care center. The purpose of the present study was to evaluate demography about medication errors, drugdrug interactions and rationality of Prescription in general medicine ward and surgery ward at a tertiary care hospital.…”

Section: Introductionmentioning

confidence: 99%

Study of Medication Error in Hospitalised Patients in Tertiary Care Hospital

Patel¹,

Patel²,

Patel³

et al. 2018

IJOPP

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AIM:The aim of the present investigation is to study the incidence medication error (ME) in hospitalized patients in a tertiary care hospital. Further, the study was aimed to categorize medication error in the hospitalized patients of surgery and general medicine wards of tertiary care hospital. Method: A prospective observational study of seven months was conducted in the department of surgery ward and general medicine ward at Jivraj Mehta Smarak and Health Foundation. Data were collected using structured data collection form. Major Findings are recorded for the demographic details, drug details and criteria for identifying errors and their categorization, details of drugs involved in errors and rationality of prescription. Result: The study was conducted in 427 patients, where 231 were males (54%) and 196 were females (46%). Out of 427 cases, MEs has detected in 196 cases (45.90%). Most of the medication errors were observed in the age group of 41-60 years (34.69%). Reported incidences of MEs, 99 (51%) and 97(49%) were observed in surgery and general medicine department, respectively. The most frequent error was prescription errors (138; 70.40%) followed by administration errors (58; 29.59%). A potential drug interactions were observed in 95 cases (48%) and serious drug interactions in 28 cases (14%). Majority prescriptions were semi-rational (178; 41.68%) followed by irrational (96; 22.48%) and rational (135; 31.61%). On the evaluation of severity, majority of MEs were category C (118; 60%) followed by category B (44; 22%) and category A (34; 17%). Majority of MEs were belonging to cardiovascular drugs (23; 23%) in medicine ward and gastrointestinal drugs (29; 29%) in surgery ward. Conclusion: The study helps to assess the incidence of medication error and to categorize medication error. In the general medicine department, the majority of patients were geriatrics who are more prone to errors, thus guidelines for safe use of medications in geriatrics should be strictly implemented to prevent medication errors. Antimicrobials are the major class of drugs involved in medication errors, thus this study recommends strict implementations of antibiotic policy in the hospital.

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Section: Introductionmentioning

confidence: 99%

Study of Medication Error in Hospitalised Patients in Tertiary Care Hospital

Patel¹,

Patel²,

Patel³

et al. 2018

IJOPP

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“…The Malaysian Adverse Drug Reaction Monitoring Program receives and monitors spontaneous reporting on ADRs [9]; however, besides annual reports on ADRs from this monitoring program, data on other types of ADEs are still lacking in Malaysia. In a recent study conducted in two medical wards of a government hospital, Karuppannan et al [10] estimated the prevalence of ADE-related hospital admissions to be 39%; however, data on patients seeking treatment for an ADE in the ED are often not reflected in hospital-based studies because not all of these patients may eventually get admitted [11]. In this study, we sought to determine factors associated with ED visits resulting from medication use.…”

Section: Introductionmentioning

confidence: 98%

Factors Associated with Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia

2017

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Introduction Adverse drug events (ADEs) are a significant health problem globally, with the emergency department (ED) being an important environment for the detection of ADEs. Data regarding drug-related visits to the ED in Malaysia are currently limited.Objectives The aim of this study was to determine factors associated with prescription drug-related ED visits at a teaching hospital. Methods A case-control study was conducted on patients who visited the ED of Hospital Universiti Sains Malaysia over a 7-week period between December 2014 and January 2015. A visit to the ED was considered drug-related if the chief presenting complaint was related to prescription drug use. Data were collected by interviewing patients, and also from the patient's medical record. Multiple logistic regression was applied to determine the risk factors. Results Overall, 144 physician-identified patients with drug-related ED visits were considered as cases and 288 patients with non-drug-related complaints were selected as controls. Independent risk factors identified for drug-related ED visits were female sex (adjusted odds ratio [OR] 1.7, 95% confidence interval [CI] 1.03-2.71), currently taking regular medication (OR 3.4, 95% CI 1.87-6.05), concurrent comorbidity (OR 2.3, 95% CI 1.28-4.10), a history of drug allergy (OR 5.36, 95% CI 2.30-12.48), and recent hospital admission (OR 2.85, 95% CI 1.23-4.10). Independent risk factors were also associated with the following health problems: diabetes mellitus (OR 6.83, 95% CI 3.30-14.12), central nervous system disorders (OR 9.42, 95% CI 3.08-14.12), and cardiovascular disorders (OR 2.5, 95% CI 1.25-4.79).Conclusions The determinants of a drug-related ED visit at a teaching hospital are multifactorial. Interventions to prevent future occurrences should focus on those patients at risk. Key PointsFemale sex, receiving regular medication, having a history of drug allergy, and recent hospital admission are risk factors for prescription drug-related emergency department (ED) visits.Patients with health problems such as diabetes, central nervous system disorders, and cardiovascular disorders also have a higher risk of ED visits related to drug use.The most common drug classes involved with drugrelated ED visits were antidiabetic agents, antihypertensives, antibiotics, anti-asthmatics, and diuretics.

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“…In our study anti-diabetic drugs were used in 30.2% of study population where as it was 40% reported in another study 6 . Most commonly used antidiabetic drug was metformin either alone or in combination (75.6%), followed by sulfonylureas (56.0%).…”

Section: According To Nhms 2011mentioning

confidence: 99%

“…Higher drug intake may also subject them to the problems of polypharmacy like drug-drug and drug-disease interactions, decreased compliance in prescribed drugs, increased iatrogenic illnesses leading to increased healthcare related costs 6 .…”

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2017

IJPSR

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ABSTRACT:This study explored self-reported chronic illnesses and use of prescription medicines (PM) by elderly Malays in the community. The study was a population based cross sectional study conducted among 490 Malay subjects aged ≥ 60 years in the semi-urban and rural areas in Perak, Malaysia. The study was conducted using pre-validated questionnaires after getting informed consent from the study participants. Critically ill and subjects with cognitive impairment were excluded from the study. The mean age of the elderly respondents was 69.7 years and 68.4% of the elderly were females. Respondents belonging to the age group 60-69 years constituted the largest group (54.5%). The most common illness reported was hypertension (59.8%) followed by hypercholesterolemia (42.7%) and diabetes mellitus (32.2%). Other chronic illnesses were osteoarthritis (6.3%), bronchial asthma (4.1%), other cardiovascular diseases (2.2%) and other diseases (19.2%). 52.9% of elderly study subjects had multiple illnesses. 76.7% used at least one prescription medication. The highest users of PM were aged between 70-79 years, while the lowest users of PM were ≥ 80 years old (p<0.05). Female elderly used more medication (79.4%) compared to males (71%) and it was statistically significant. Urban elderly used more PM (79.1%) which was significantly different from their rural counterparts (67%). Anti-hypertensive drugs were the most commonly used medication (59.4%) followed by anti-cholesterol drugs (41.4%), anti-diabetics (30.2%), anti-osteoarthritis drugs (4.3%) and anti-asthma drugs (2.9%).

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The prevalence of adverse drug event-related admissions at a local hospital in Malaysia

Cited by 10 publications

References 30 publications

Study of Medication Error in Hospitalised Patients in Tertiary Care Hospital

Study of Medication Error in Hospitalised Patients in Tertiary Care Hospital

Factors Associated with Drug-Related Emergency Department Visits at a Teaching Hospital in Malaysia

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