The prevalence of airway obstruction among Japanese HIV-positive male patients compared with general population; a case–control study of single center analysis

Nakamura, Hideta; Tateyama, Masao; Tasato, Daisuke; Haranaga, Shusaku; Ishimine, Tomohiko; Higa, Futoshi; Kaneshima, Hiroshi; Fujita, Jiro

doi:10.1016/j.jiac.2014.02.001

Cited by 17 publications

(16 citation statements)

References 26 publications

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“…77 One multiregional study included all WHO regions. 38 The fixed-ratio definition was used in 16 studies, 47,56,61,62,64,66,70,[72][73]75,[78][79][80][81]83 LLN was used in six, 38,47,56,66,75,83 ICD was used in five, 38,47,56,58,66,75,83 and patient-reported criteria were used in nine studies. 59,65,[67][68][69]74,76,77,82 One study was in Spanish.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis

Bigna

Kenne

Asangbeh

et al. 2018

The Lancet Global Health

147

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Section: Resultsmentioning

confidence: 99%

Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis

Bigna

Kenne

Asangbeh

et al. 2018

The Lancet Global Health

147

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“…However, spirometric measurements were not significantly different between HIV‐infected and HIV‐uninfected individuals with similar risk factors for obstructive lung disease . Since the advent of ART, however, several cross‐sectional studies have documented a high prevalence of airflow obstruction among HIV‐infected individuals, and have described an association with risk factors such as cigarette smoking, previous opportunistic infections, markers of HIV infection and ART use . A survey of 234 HIV‐infected adults (mean age 44, 82.5% male, 59.8% current or former smokers) without acute respiratory symptoms found that 8.6% had a ratio of forced expiratory volume in 1 s to forced vital capacity (FEV 1 /FVC ratio) below the lower limit of normal; older age, greater number of pack‐years smoked, previous bacterial pneumonia and the use of ART were independent predictors .…”

Section: Lung Function In Hiv‐infected Adultsmentioning

confidence: 99%

“…Several studies with age‐ and smoking‐match HIV‐negative comparator groups have reported that COPD is significantly overrepresented in HIV‐infected patients compared with their uninfected counterparts . A recent case–control study from Japan found a prevalence of spirometric obstruction of 10.2% in HIV‐infected participants versus only 2.4% in HIV‐negative controls, and found that HIV infection (but not ART use) was an independent risk factor for airway obstruction even after adjusting for age and pack‐years of smoking. Despite the high burden of HIV infection in sub‐Saharan Africa, there is a paucity of data on lung function in HIV‐infected individuals from this region.…”

Section: Lung Function In Hiv‐infected Adultsmentioning

confidence: 99%

Lung function abnormalities in HIV‐infected adults and children

Calligaro

Gray

2014

Respirology

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Despite the advent of antiretroviral therapy (ART), the human immunodeficiency virus (HIV) epidemic remains a global health crisis with a high burden of respiratory disease among infected persons. While the early complications of the epidemic were dominated by opportunistic infections, improved survival has led to the emergence of non-infectious conditions that are associated with chronic respiratory symptoms and pulmonary disability. Obstructive ventilatory defects and reduced diffusing capacity are common findings in adults, and the association between HIV and chronic obstructive pulmonary disease is increasingly recognized. There is synergism between viral factors, opportunistic infections, conventional influences like tobacco smoke and biomass fuel exposure, and potentially, the immunological effects of ART on the development of HIV-associated chronic obstructive lung disease. Pulmonary function data for HIV-infected infants and children are scarce, but shows that bronchiectasis and obliterative bronchiolitis with severe airflow limitation are major problems, particularly in the developing world. However, studies from these regions are sorely lacking. There is thus a major unmet need to understand the influences of chronic HIV

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“…28,29 With the introduction of HAART and subsequent immunological recovery of patients, pathology as cronical obstructive pulmonary diseases (COPD), a widely spread disease in the general population, caused most significantly by smoking, 30 will increase and will probably become a new and significant comorbidity for HIV patients, especially where there is airway colonization by PCP. 31 Hence, it would be advisable to conduct early diagnosis screening of COPD in HIV patients with predisposing risk factors, 32 aimed at taking preventive measures. In a future healthcare providers should be aware of the increased likelihood of airway obstruction among HIV patients.…”

Section: Discussionmentioning

confidence: 99%

Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients

Perelló

Escoda

Camón

et al. 2015

Enfermedades Infecciosas y Microbiología Clínica

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a b s t r a c tAim: To describe the, incidence, the changes in the etiology and the prognosis of lower respiratory tract infection (LRTI) in HIV infected patients, presenting by the first time to the Emergency Department (ED), during years 2000-2010. Study design: Prospective collection of data. Metbods: Data were collected on the first visit of HIV-infected patients at our ED due to a LRTI, (defined according to the criteria of the European Respiratory Society), between 1/1/2000 and 31/12/2010. A series of epidemiological and laboratory variables as well as the need for admission to the intensive care unit (ICU). LRTI etiology were also collected. The influence ofthe mentioned variables on 30-day mortality were analyzed. Results: One hundred thirty one patients were included. LRTI represented 27% of visits to the ED by HIV-infected patients. Mean age was 39±9 years. 72% of patients were males. 18% required admission to the ICU. The most frequent LRTI was pneumonia by P. jiroveci in 35 cases, bacterial penumonia in 27 and pulmonary tuberculosis in 20. LRTI incidence gradually reduced significantly over time from 6.13 × 1000 patients/year in year 2000 to 0.23 × 1000 patients/year in 2010 (p<0.05). Overall mortality was 14%. Logistic regression analysis showed that admission to ICU (p<0.004) and viral load (p<0.029) were independent variables predicting mortality. Conclusion: LRTI is a pathology with a decreasing incidence, probably related to the widespread utilization increased of HAART regimens. lts etiology has also been changing, but with a non negligible mortality, mostly when ICU admission was required.© 2014 Elsevier España, S.L.U. and Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.Cambios en la etiología, incidencia y pronóstico de la infección respiratoria aguda de vías bajas en pacientes infectados por el virus de la inmunodeficiencia humana Infecc Microbiol Clin. 2014;xxx(xx):xxx-xxx así como la necesidad de ingreso en una unidad de cuidados intensivos (UCI). Se estudió la etiología de la IRVB y la incidencia. Finalmente se analizaron la influencia de las variables con la mortalidad a 30 días. Resultados: Se incluyeron un total de 131 pacientes. La edad media fue de 39 ± 9 años. El 72% de los pacientes eran varones y el 18% de los pacientes requirieron ingreso en la UCI. La IRVB más frecuente fue la neumonía por P. jirovecci, seguida de la neumonía bacteriana en 27 y la tuberculosis pulmonar en 20. La incidencia de IRVB se ha ido reduciendo gradualmente de forma significativa, 6,13 × 1.000 pacientes/año en 2000 a 0,23 × 1.000 pacientes/año en 2010 (p < 0,05). El análisis de regresión logística mostró que la única variable que predijo mortalidad fue el ingreso en UCI (p < 0,05; OR: 73,01). Conclusión: La IRVB es una enfermedad cuya incidencia y etiología han ido disminuyendo y cambiando respectivamente, probablemente en relación con la utilización generalizada del TAR. Sin embargo, todavía presenta una mortalidad nada despreciable, que es mayor cuando el paci...

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The prevalence of airway obstruction among Japanese HIV-positive male patients compared with general population; a case–control study of single center analysis

Cited by 17 publications

References 26 publications

Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis

Prevalence of chronic obstructive pulmonary disease in the global population with HIV: a systematic review and meta-analysis

Lung function abnormalities in HIV‐infected adults and children

Changes in the etiology, incidence and prognosis of acute lower respiratory track infections in human immunodeficiency virus patients

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