The prevalence of and risk factors for radiographic vertebral fractures in older Indian women and men: Delhi Vertebral Osteoporosis Study (DeVOS)

Marwaha, Raman K.; Tandon, Nikhil; Gupta, Yashdeep; Bhadra, Kuntal; Narang, Amit; Kalaivani, Mani; Mithal, Ambrish; Kukreja, Subhash C.

doi:10.1007/s11657-012-0098-8

Cited by 51 publications

(40 citation statements)

References 13 publications

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“…The greater bone density in Africans may be protective of fractures, given that fracture rates are similar in AI and Caucasian women (37), whereas BA have lower fracture rates compared with other ethnic groups (3). Our study showed that the BA group had greater BMD at all four sites compared with the AI group.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Body Composition, 25(OH)D, and PTH and Bone Mineral Density in Black African and Asian Indian Population Groups

George

Micklesfield

Norris

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionmentioning

confidence: 99%

The Association Between Body Composition, 25(OH)D, and PTH and Bone Mineral Density in Black African and Asian Indian Population Groups

George

Micklesfield

Norris

et al. 2014

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…It is possible that not assessing L 2 to L 5 has resulted in an underestimation because of missing prevalent and/or incident VFs in this lumbar area. However, according to literature, most VFs occur in the mid-thoracic and thoracolumbar area of the spine, (55)(56)(57)(58)(59)(60) which are both visible on chest CT scans.…”

Section: Limitationsmentioning

confidence: 99%

High Imminent Vertebral Fracture Risk in Subjects With COPD With a Prevalent or Incident Vertebral Fracture

Dort

Geusens

Driessen

et al. 2018

Journal of Bone and Mineral Research

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Subjects with chronic obstructive pulmonary disease (COPD) have an increased risk of vertebral fractures (VFs); however, VF incidence is largely unknown. Therefore, the aim of our study was to determine the incidence of new and/or worsening VF in subjects with COPD. Smokers and subjects with COPD (GOLD II-IV) from the ECLIPSE study with complete set of chest CT scans (baseline and 1-and 3-year follow-up) to evaluate vertebrae T 1 down to L 1 were included. If a VF was diagnosed on the last scan, detailed VF assessment of the previous scans was performed. VFs were scored according to the method of Genant as mild, moderate, or severe. Main outcome measure was the cumulative incidence of new and/or worsening VF at subject level, within 1 and 3 years. Of 1239 subjects (mean age 61 years, 757 males [61%], 999 subjects with COPD), 253 (20.5%) had !1 prevalent VF. The cumulative incidence of VFs was 10.1% within 1 year and 24.0% within 3 years. After adjustment for age, sex, body mass index (BMI), pack-years, and smoking status, prevalence and incidence were similar between smokers and COPD GOLD stages. Within 1 year, 29.2% of the subjects with a prevalent VF had an incident VF, compared with 5.1% in absence of prevalent VF (hazard ratio [HR] ¼ 5.1; 95% confidence interval [CI] 3.6-7.4) and 58.5% versus 15.0% within 3 years (HR ¼ 3.6; 95% CI 2.9-4.6). The incidence of VF was higher with increasing number and severity of prevalent VFs. Among subjects having an incident VF within the first year, 57.3% had a subsequent VF within the next 2 years. In this study, more than half of the smokers and subjects with COPD with a prevalent VF or an incident VF within the first year sustained a subsequent VF within 3 years. The 3-year risk was even higher in the presence of multiple or severe prevalent VFs.

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“…The prevalence of radiographic vertebral fractures in older adults in Delhi has been recently reported to be 17.9% (18.8% male and 17.1% female); indicating that vertebral fracture prevalence in India is similar to Western populations [Figure 5]. [26]…”

Section: Fracture Ratesmentioning

confidence: 99%

The Asia-Pacific Regional Audit-Epidemiology, costs, and burden of osteoporosis in India 2013: A report of International Osteoporosis Foundation

Mithal

Bansal

Kyer

et al. 2014

Indian J Endocr Metab

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252

208

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The prevalence of and risk factors for radiographic vertebral fractures in older Indian women and men: Delhi Vertebral Osteoporosis Study (DeVOS)

Abstract: The prevalence of vertebral fractures among older Indians was comparable to that reported in Caucasian populations. Prevalence of vertebral fractures increased with age in females, but not in males. Overweight individuals were protected against vertebral fractures.

Cited by 51 publications

References 13 publications

The Association Between Body Composition, 25(OH)D, and PTH and Bone Mineral Density in Black African and Asian Indian Population Groups

The Association Between Body Composition, 25(OH)D, and PTH and Bone Mineral Density in Black African and Asian Indian Population Groups

High Imminent Vertebral Fracture Risk in Subjects With COPD With a Prevalent or Incident Vertebral Fracture

The Asia-Pacific Regional Audit-Epidemiology, costs, and burden of osteoporosis in India 2013: A report of International Osteoporosis Foundation

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