The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Argentina

Eddi, C.; Caracostantogolo, J.; Peña, María; Schapiro, J.; Marangunich, L.; Waller, P.J.; Hansen, Julie Elvekjær

doi:10.1016/0304-4017(95)00905-1

Cited by 51 publications

(30 citation statements)

References 6 publications

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“…AHR in small ruminants has been reported in various regions of world: Argentina (EDDI et al, 1996); Uruguai (NARI et al, 1996;BONINO & MEDEROS, 2003), Paraguai (MACIEL et al, 1996); South Africa ( VAN WYK et al, 1997); Mexico (TORRES-ACOSTA et al, 2003); Australia (SUTER et al, 2004;PLAYFORD et al, 2014) (ZANZANI et al, 2014);Ireland (KEANE et al, 2014); France, Greece and Italy (GEURDEN et al, 2014). The countries with the largest number of cross-sectional studies over time are New Zealand, the United Kingdom and Brazil (FALZON et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Salgado

Santos

2016

Rev. Bras. Parasitol. Vet.

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Frequent and inappropriate use of all classes of antiparasitic drugs in small ruminants has led to failures in their effectiveness, culminating in a global problem of anthelmintic resistance. Brazil stands out as one of the world's leaders in publications about anthelmintic resistance, and for having the most numerous reports of this resistance in small ruminants in the Americas. These studies have involved mainly the fecal egg count reduction test (FECRT) and its correlation with field management practices. In vivo effectiveness testing is conducted in areas where livestock is of greater economic significance, e.g., in the South (sheep) and Northeast (goats), or is important for research and economic centers, such as the Southeast (sheep). The most widely studied species is sheep, for which the widest range of drugs is also evaluated. Despite significant advances achieved in molecular research, laboratory analyses should include knowledge about the reality in the field so that they can become feasible for the producer. Moreover, molecular studies can be underpinned by the analysis of field studies, such as the maintenance of antiparasitic effectiveness over time and the mechanisms involved in this process.Keywords: Small ruminants, anthelmintic resistance, sheep, goat, gastrointestinal nematodes. ResumoO uso frequente e inapropriado de todas as classes de antiparasitários em pequenos ruminantes levou a falhas de eficácia, culminando na problemática global de resistência anti-helmíntica. O Brasil destaca-se como sendo um dos pioneiros nas publicações com resistência anti-helmíntica no mundo e por ter o maior número de relatos em pequenos ruminantes na América. Essas pesquisas envolvem principalmente o teste da redução da contagem de ovos nas fezes (TRCOF) e sua correlação com as práticas de manejo utilizadas no campo. Os estudos de testes de eficácia in vivo localizam-se em áreas onde há maior importância dos rebanhos como nas Regiões Sul (ovinos) e Nordeste (caprinos), ou com importância em polos de pesquisa e econômicos, como a região Sudeste (ovinos). Ovina é a espécie mais estudada e com maior gama de drogas avaliadas. Mesmo com grande avanço em pesquisas moleculares, as análises laboratoriais devem envolver o conhecimento da realidade do campo para que possam se tornar viáveis ao produtor. Além disso, a análise dos estudos de campo pode nortear estudos moleculares como, por exemplo, a manutenção da eficácia das drogas ao longo dos anos e os mecanismos envolvidos em tal processo.

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Section: Introductionmentioning

confidence: 99%

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Salgado

Santos

2016

Rev. Bras. Parasitol. Vet.

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“…Para la década de 1990, la resistencia antihelmíntica ya era un problema generalizado. Los informes de helmintos resistentes a múltiples fármacos aumentaron, por lo que el fenómeno pasó a ser percibido como una amenaza importante para la producción de pequeños rumiantes en varias partes del mundo (34) como África, Argentina, Paraguay, Brasil y Uruguay, donde cabras y borregos fueron tratados durante un breve periodo de tiempo con tiabendazol y se observó el desarrollo de resistencia rápida a las tres principales clases de antihelmínticos (35) .…”

Section: La Resistencia a Los Antihelmínticosunclassified

El nematodo Caenorhabditis elegans como modelo para evaluar el potencial antihelmíntico de extractos de plantas

Peña

Vazquez

Sánchez

et al. 2017

Rev. Mex. Cienc. Pecu.

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RESUMENLos nematodos parásitos afectan la productividad pecuaria, dando lugar a pérdidas económicas considerables. Sin embargo, son pocos los antihelmínticos disponibles en el mercado y la resistencia de los parásitos a los existentes va en incremento, por lo que su control es actualmente ineficiente. En este sentido, la búsqueda de nuevas estrategias para controlar la parasitosis es una necesidad actual. Una posibilidad para el control estriba en la investigación de metabolitos derivados de plantas, ya que el conocimiento sobre su uso tradicional es un referente de inicio. Sin embargo, la eficacia antihelmíntica, así como los mecanismos de acción de plantas con uso tradicional como antiparasitarios, poco se han investigado científicamente, y en la mayoría de los casos se desconocen los compuestos activos responsables del efecto anti-parasitario. Una de las limitantes del estudio experimental del potencial antihelmíntico es la dificultad de trabajar con modelos parásitos. En este sentido, el nematodo de vida libre C. elegans es un modelo útil para entender el mecanismo de acción de drogas antihelmínticas. Por un lado, este nematodo se puede mantener y manipular en laboratorio con facilidad; por otro, comparte características fisiológicas y homología genética con nematodos parásitos, lo que permite comparaciones válidas. En esta revisión se pretende mostrar el potencial de la búsqueda de compuestos activos derivados de plantas tradicionalmente utilizadas como antiparasitarios como punto de partida en el desarrollo de nuevos fármacos antihelmínticos, así como resaltar las ventajas que C. elegans proporciona para entender los mecanismos de acción de nuevos compuestos. PALABRAS CLAVE: Resistencia

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“…However, lately benzimidazoles have been replaced by endectocides, closantel and organophosphate drugs, because of the apparition of anthelmintic resistance to benzimidazoles [8].…”

Section: Characteristics Of Anthelmintic Control Strategiesmentioning

confidence: 99%

Helminthic control on grazing ruminants and environmental risks in South America

Suárez¹

2002

Vet. Res.

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-The control of ruminant gastrointestinal nematodes and ectoparasites, one of the major production health problems, are heavily reliant on the systematic and sometimes abusive use of anthelmintic drugs. Endectocides are the most frequently used drugs, having high potency against arthropods and nematodes. Their dung pat residues enhance the risk of adverse effects on non-target invertebrates and on the general grazing cattle ecosystem. In this scenario, our objective is to review current knowledge of the agro-environmental and biodiversity impact and risks of endectocides in South America. The effects of faecal drug residues of ivermectin and doramectin on dung colonising invertebrates and dung degradation have been reported in studies carried out in the temperate centre of Argentina and in the subtropical region of Brazil. The results from Argentina showed a depression in invertebrate colonisation and degradation of dung recovered from endectocide treated cattle during the autumn. Comparisons have shown that ivermectin and doramectin have similar adverse effects. A decrease of Coleoptera larvae, Diptera larvae, Staphylinidae, Collembola, Acari and dung specific nematodes was noted in pats from both endectocides. The results from Brazil showed that dipterous larvae, Polyphaga coleopteran larvae and adults and mites were significantly reduced in the ivermectin treated group. The disturbances that macrocyclic lactones can produce on non-targeted invertebrates and on their associated participation in dung degradation and soil element recycling, are unpredictable and can negatively influence biodiversity and the agricultural ecosystem sustainability.endectocide / environmental risk / South America / cattle grazing system / dung fauna Résumé -Contrôle des helminthes chez les ruminants à l'herbe et risques environnementaux en Amérique du Sud. Le contrôle des nématodes gastro-intestinaux et des ectoparasites, qui est l'un des problèmes de santé majeurs dans la production bovine, repose largement sur l'utilisation systé-matique et parfois abusive d'anthelmintiques. Les endectocides, qui ont un effet puissant contre les arthropodes et les nématodes, sont les médicaments le plus fréquemment utilisés. Leurs résidus dans les matières fécales augmentent les risques d'effets nocifs sur des invertébrés qui ne sont pas la cible 563

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The prevalence of anthelmintic resistance in nematode parasites of sheep in Southern Latin America: Argentina

Cited by 51 publications

References 6 publications

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

El nematodo Caenorhabditis elegans como modelo para evaluar el potencial antihelmíntico de extractos de plantas

Helminthic control on grazing ruminants and environmental risks in South America

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