The prevalence of antibodies to anionic phospholipids in patients with the primary antiphospholipid syndrome, systemic lupus erythematosus and their relatives and spouses

Radway-Bright, E L; Ravirajan, C. T.; Isenberg, David

doi:10.1093/rheumatology/39.4.427

Cited by 19 publications

(10 citation statements)

References 13 publications

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“…Описанные в литературе результаты исследования аФЛ в семьях больных аутоиммунными заболеваниями, АФС (чаще АФС в сочетании с СКВ), а также среди родственников бессимптомных носителей аФЛ широко варьируют вследствие разнородности изучаемых групп. В ряде работ обсуждается соотносительная роль генетических и средовых факторов, влияющих на синтез аФЛ [15,21]. Так, E. L. Radway-Bright и соавт.…”

Section: Discussionunclassified

“…значительно чаще обнаруживались у родственников больных ВАФС, тогда как распространенность тех же антител у супругов не имела отличий от контроля. Авторами был сделан вывод о преимущественном влиянии генетических факторов в отличие от средовых на распространенность аФЛ [21]. В нашем исследовании преобладающее влияние наследственных факторов на синтез ВА подтверждает его обнаружение более чем в пять раз чаще у родственников ВА-позитивных больных АФС по сравнению с родственниками пробандов с отрицательными результатами исследования ВА.…”

Section: Discussionunclassified

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Clinico-genealogical investigation of antiphospholipid syndrome

Чапаева¹,

Трифонова²

2009

rsp

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Антифосфолипидный синдром (АФС), согласно классификации Национального института здоровья США (NIH), определяется как редкое заболевание, которым страдает менее чем 200 тыс. человек в американской популяции [26]. Orphanet, информационный ресурс по редким болезням, также относит АФС к группе редких заболеваний, развивающихся не более чем в одном случае на 2000 населения (0,05%) [25]. Низкая распространенность АФС обусловливает трудности его диагностики и разработки методов профилактики. Актуальность изучения АФС определяется рядом социально-эпидемиологических аспектов. Заболевание развивается преимущественно в молодом возрасте, при этом АФС может проявиться у детей и даже новорожденных [2]. Проспективные исследования свидетельствуют об ассоциации антифосфолипидных антител (аФЛ) с первым эпизодом венозного тромбоза [11], первым инфарктом миокарда [27] и рецидивирующими инсультами [14]. Среди пациентов моложе 45 лет с инсультом неясной этиологии аФЛ обнаруживаются у 25% [17]. У больных системной красной волчанкой (СКВ) циркуляция аФЛ является независимым предиктором летального исхода [6]. В отличие от распространенных мультифакториальных заболеваний (МФЗ) (ишемическая болезнь сердца -ИБС, бронхиальная астма, сахарный диабет 2-го типа и др.), клинико-генеалогические Клинико-генеалогическое исследование антифосфолипидного синдрома Н. Н. Чапаева, М. А. Трифонова Новосибирский государственный медицинский университет МЗ и СР РФ Адрес: 630099 г.Новосибирск, ул. Оржоникиззе 23-20 Е-mail: n.chapaeva@mail.ru N.N. Chapaeva, M.A. Trifonova Clinicogenealogical investigation of antiphospholipid syndromeObjective. Clinicogenealogical investigation of the families of patients with antiphospholipid syndrome (APS). Material and methods. Families of 82 pts with APS fulfilled diagnostic criteria of S. Miyakis et al., 2006 (mean age 47,2±12,1 years, men:women ratio 1:10,7) were studied. "Severe" course of APS (43 patients) was characterized by presence of recurrent thrombotic events and/or thrombosis of several types and/or localizations. Clinicogenealogical investigation included pedigrees analysis (the number of relatives -615). 46 individuals -relatives of 26 patients with APS (37 first-degree and 9 second-degree relatives, mean age 29,5±16,4 years) were followed up for 4 years. Incidence of "minor" features (livedo reticularis, neurological disorders, heart valves disease, thrombocytopenia) was studied, lupus anticoagulant (LA) test was performed. Statistical analysis was performed with Student's t test and logistic regression analysis (SPSS 11.5.0). Results. Definite APS was diagnosed in 7 individuals, more frequently -in first-degree relatives and women (the most frequent form of inheritance -mother/daughter). "Minor" features were precursors of APS in 76% patients with APS. These features were found in more than half relatives. LA was detected in 39% of relatives. LA was 5-fold more prevalent in relatives of LA-positive patients with APS as compared with relatives of LA-negative patients. Primary prevention of thrombosis has been...

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Section: Discussionunclassified

Clinico-genealogical investigation of antiphospholipid syndrome

Чапаева¹,

Трифонова²

2009

rsp

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“…Unfortunately, in only one family, a nonaffected sibling also was tested; thus, we cannot discriminate between shared genes and shared environment. Familial aggregation has been demonstrated for different families of autoantibodies, such as antinuclear, antiphospholipid, 16 antigoblet, 17 and antithyroid. 18 In most cases, autoantibodies have been analyzed in relatives and spouses of subjects with autoimmune disorders.…”

Section: Discussionmentioning

confidence: 99%

A Deiminated Viral Peptide to Detect Antibodies in Rheumatoid Arthritis

Merlini

Anzilotti

Chimenti

et al. 2005

Annals of the New York Academy of Sciences

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The data presented suggest that a deiminated viral peptide is specifically recognized by antibodies contained in rheumatoid arthritis (RA) sera. Antipeptide antibodies are not associated with the presence or severity of specific manifestations of RA, but are more frequent in subjects with erosive arthritis. Taking into account the association with rheumatoid factor and with erosive arthritis, we can conclude that antipeptide antibodies are markers of severe forms of RA. Our data also show familial aggregation of anticitrullinated peptide antibodies.

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“…In the first case, autoantibodies usually are IgM natural antibodies or low‐affinity IgG 1 . Otherwise, autoantibodies can be detected in the serum of healthy first‐degree relatives of patients with autoimmune diseases, such as SLE, APS, and RA 2–6 . In the second case, autoantibodies can predict the future development of AD.…”

Section: Introductionmentioning

confidence: 99%

“…There are situations in which autoantibodies are positive in healthy subjects. In particular, three different conditions can be described: latent autoimmunity, preclinical autoimmunity, and postclinical autoimmunity ( [2][3][4][5][6] In the second case, autoantibodies can predict the future development of AD. For example, it has been demonstrated that several antibodies can be detected many years before the diagnosis or the first clinical manifestation.…”

Section: Introductionmentioning

confidence: 99%

Seronegative Autoimmune Diseases

Alessandri

Conti

Conigliaro

et al. 2009

Annals of the New York Academy of Sciences

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A close relationship exists between autoimmunity and autoantibodies; despite this, some patients are persistently negative for disease-specific autoantibodies. These conditions have been defined as seronegative autoimmune diseases. Although the prevalence of seronegative autoimmune diseases is low, they may represent a practical problem because they are often difficult cases. There are also situations in which autoantibodies are positive in healthy subjects. In particular, three different conditions can be described: latent autoimmunity, preclinical autoimmunity, and postclinical autoimmunity. Here, we analyze briefly the meaning of autoantibody negativity in the seronegative autoimmune diseases, focusing in particular on the specificities associated with systemic lupus erythematosus, antiphospholipid syndrome, and rheumatoid arthritis.

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The prevalence of antibodies to anionic phospholipids in patients with the primary antiphospholipid syndrome, systemic lupus erythematosus and their relatives and spouses

Abstract: Genetic factors, shared by patients and their relatives, seem to have some effect on the prevalence of aPL in the subjects studied, while environmental factors shared by spouses appear to have no influence.

Cited by 19 publications

References 13 publications

Clinico-genealogical investigation of antiphospholipid syndrome

Clinico-genealogical investigation of antiphospholipid syndrome

A Deiminated Viral Peptide to Detect Antibodies in Rheumatoid Arthritis

Seronegative Autoimmune Diseases

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