The Prevalence of Bacterial Intestinal Pathogens in a Healthy Rural Population in Southern India

Mathan, V. I.; Rajan, D. Prasanna

doi:10.1099/00222615-22-2-93

Cited by 18 publications

(11 citation statements)

References 13 publications

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“…None of the individuals had any apparent ill effects because of the parasites. We have also reported a high prevalence of asymptomatic colonization of the intestinal tract by pathogenic enteric bacteria and enteroviruses in this population (Patel et al 1984;Mathan & Rajan 1986). This would appear to be the norm for gut ecology in many preindustrialized countries.…”

Section: Discussionmentioning

confidence: 58%

Prevalence of intestinal parasites in rural Southern Indians

Kang

Mathew

Rajan

et al. 1998

Tropical Med Int Health

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132

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SummaryOBJECTIVE To determine the prevalence of intestinal protozoal and helminthic infection in a rural population. METHOD Seventy-eight members of 15 families from a village were studied. Stool samples from all subjects were examined on alternate days for one month. RESULTS The overall prevalence rate of various parasitic infections was 97.4%, with only 2 of 78 subjects not excreting parasites in any of their 15 samples. Eighteen (23.1%) persons had only one type of parasite, while 58 (74.3%) excreted multiple parasites. Giardia and Cryptosporidium were the commonest protozoan infections, affecting 42/78 (53.8%) and 31/78 (39.7%), respectively. Hookworm infestations were the commonest helminthic infections, seen in 48/78 (61.5%). Based on excretion patterns, the asymptomatic individuals could be divided into 2 groups of infrequent and frequent excretors, indicating that the host response may determine the level of parasite replication in the gut.keywords parasite prevalence, intestinal parasites, India correspondence G. Kang,

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Section: Discussionmentioning

confidence: 58%

Prevalence of intestinal parasites in rural Southern Indians

Kang

Mathew

Rajan

et al. 1998

Tropical Med Int Health

Self Cite

132

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“…The two well characterized mechanisms of pathogenesis, enterotoxins and tissue invasion, account for only a small proportion of patients with diarrhea and microbial enteric pathogens cannot be identified in stool samples from 20 to 40% of patients (1). Recognized microbial enteric pathogens can be isolated from the stools of up to a third of apparently healthy asymptomatic individuals resident in many tropical developing countries (2)(3)(4)(5). This wide prevalence of enteric pathogens in asymptomatic individuals does not appear to increase their resistance to diarrhea, since its endemicity and consequent mortality continue to be high in such areas.…”

Section: Introductionmentioning

confidence: 99%

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Mathan

Penny²,

Mathan³

et al. 1988

J. Clin. Invest.

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Subcutaneous challenge of mice with lipopolysaccharide (LPS) from gram negative bacteria, produced an intestinal microvascular lesion causing fluid exudation into the lumen of the intestine and diarrhea. The microvascular lesion was characterized by endothelial cell damage and microthrombi in the venules and capillaries of the intestinal lamina propria. Marker organisms, given orally to challenged mice, grew in the exuded fluid and could invade the mucosa. Intravenous transfer of postchallenge plasma produced the lesion in normal mice and absorption of such plasma by Sepharose coupled to LPS-antibody abolished this effect. Instillation of large quantities of LPS into the lumen of the intestine produced scattered microvascular lesions, although none of these animals developed diarrhea. Since a similar microvascular lesion has been described in the rectal mucosal lamina propria of adults with acute diarrhea, it is suggested that LPS-induced vascular damage may be a novel mechanism in the pathogenesis of acute diarrhea.

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“…More recently, other Campylobacter species have been recognized as gastrointestinal pathogens in both industrialized and developing countries (8,11). In developing countries, the isolation of Campylobacter from children without diarrhoea is well-documented and it is probably related to poor environmental sanitary conditions and close contact with animals (2,5,15). Among children with diarrhoea, the isolation rates of Campylobacter is higher among malnourished than well-nourished children (10,14), and a strong correlation exists between malnutrition, diarrhoeal illness and poor sanitary conditions (13,18).…”

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confidence: 99%

Occurrence of campylobacter species in healthy well-nourished and malnourished children

Fernández

Vera

Villanueva

et al. 2008

Braz. J. Microbiol.

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The occurrence of Campylobacter species in healthy, well-nourished and healthy, malnourished children of low socioeconomic level in Southern Chile was determined. Campylobacter carriers were significantly most frequent among malnourished (31.4%) than among well-nourished (9.9%) children. Six species were isolated from malnourished children whereas four were found among well-nourished children. C. upsaliensis was the most frequent (13.3%) species isolated from malnourished children, followed by C. lari (7.6%) and C. fetus ssp. fetus (1.9%).

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The Prevalence of Bacterial Intestinal Pathogens in a Healthy Rural Population in Southern India

Cited by 18 publications

References 13 publications

Prevalence of intestinal parasites in rural Southern Indians

Prevalence of intestinal parasites in rural Southern Indians

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Occurrence of campylobacter species in healthy well-nourished and malnourished children

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