The Prevalence of Benign and Malignant Tumors in Patients with Acromegaly at a Single Institute

Kurimoto, Makiko; Izumi, Fujio; Hizuka, Naomi; Takano, Kazue

doi:10.1507/endocrj.k07e-010

Cited by 72 publications

(62 citation statements)

References 22 publications

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“…In one study, the rate of colonic lesions was 51.7%, and 10.3% of it was colon carcinoma [19]. In our study, the colonic lesion prevalence was observed as 30.2%, and no carcinoma was found.…”

Section: Discussionsupporting

confidence: 49%

Prevalence and recurrence rate of colonic lesions in acromegalic patients

et al. 2010

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AbstractAcromegaly is associated with an increased prevalence of colonic polyps. The aim of this study was to evaluate the prevalence and recurrence rate of colonic polyps in acromegalic patients. Ninety-six acromegalic patients and 100 irritable bowel syndrome patients (IBS) were enrolled in the study. Twenty patients who were cured exclusively by surgery, and 20 patients that could not be hormonally controlled were re-examined colonoscopically after 36 months. Twenty-nine of 96 acromegalic patients (30.2%) had colonic polyps. In the IBS group, 10 (10.0%) had colonic polyps. The prevalence of colonic polyps was significantly higher in acromegaly. The group of acromegalic patients with and without polyps did not differ significantly with regard to plasma GH, IGF-I, fasting insulin levels and glycemic status. The presence of colonic polyps was correlated with increased patient age and male gender. We did not observe a difference in terms of polyp recurrence frequencies in the patients cured by surgery compared to uncontrolled patients. Acromegalic patients have a higher prevalence of colonic polyps than that of control subjects. We could not identify any factors that could predict polyps within the acromegalic patients - but age and male sex.

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Section: Discussionsupporting

confidence: 49%

Prevalence and recurrence rate of colonic lesions in acromegalic patients

et al. 2010

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“…Studies suggest that acromegalic patients present higher risk of developing both benign and malignant tumors including the ones that affect the gastrointestinal tract, thyroid, and skin (6,7). The correlation between acromegaly and prostate cancer, until the present moment, is circumstantial.…”

Section: Introductionmentioning

confidence: 99%

Frequency of various types of neoplasia in a group of acromegalic patients

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et al. 2013

Arq Bras Endocrinol Metab

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Objective: To determine the frequency of colon cancer, primary hyperparathyroidism, thyroid tumor, and skin cancer in all acromegalic patients in follow-up at the Clinics Hospital -Botucatu Medical School, from 2005 to 2011. Subjects and methods: These patients were evaluated retrospectively for colon cancer, primary hyperparathyroidism, dermatological, and thyroid tumors. Results: Of 29 patients included at the beginning of the study, two were excluded. Among 19 patients submitted to colonoscopy, one presented colon adenocarcinoma (5%). Thyroid nodules were present in 63% of patients, and papilliferous carcinoma was confirmed in two patients (7,7%). Four patients were confirmed as having primary hyperparathyroidism (15%). The most common dermatologic lesions were thickened skin (100%), acrochordons (64%), epidermal cysts (50%), and pseudo-acanthosis nigricans Dentre os 19 pacientes submetidos à colonoscopia, um apresentou adenocarcinoma de cólon (5%). Nódulos de tireoide estiveram presentes em 65% dos pacientes e carcinoma papilífero, em dois deles (7,7%). Quatro pacientes apresentaram hiperparatireoidismo primário (15%). A maioria das lesões de pele foram: espessamento (100%), acrochordons (64%), cistos epidérmicos (50%), pseudoacantose nigricans (50%) e apenas um paciente apresentou carcinoma basocelular. Conclusão: O tamanho da amostra é pequeno, mas nossos achados confirmam a alta frequência da neoplasia da tireoide e hiperparatireroidismo neste grupo de pacientes. Arq Bras Endocrinol Metab. 2013;57(8):612-6 Descritores

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“…It is well established that acromegaly is associated with an increased prevalence of colorectal, breast, prostate and thyroid cancers, as determined in several epidemiological studies (1)(2)(3). However, it is currently unclear whether patients with acromegaly are at an increased risk of developing adrenal tumors.…”

Section: Introductionmentioning

confidence: 99%

Poorly-controlled Acromegaly Accompanied by Subclinical Adrenal Cushing's Syndrome after Surgery for Multiple Endocrine Tumors

et al. 2015

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A 48-year-old woman diagnosed with acromegaly 21 years earlier presented at our hospital with a left adrenal tumor. Her medical history included breast cancer, thyroid cancer and an incompletely resected growth hormone (GH)-producing pituitary adenoma. Endocrinological and radiological examinations revealed subclinical adrenal Cushing's syndrome. She subsequently underwent left adrenalectomy, followed by glucocorticoid replacement therapy. Her GH and insulin-like growth factor-1 levels were insufficiently controlled, and pegvisomant was administered in addition to octreotide acetate. Following adrenalectomy, a giant hepatic hemangioma and papillary thyroid carcinoma in the residual right lobe developed, indicating the high risk of tumor development in patients with acromegaly.

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The Prevalence of Benign and Malignant Tumors in Patients with Acromegaly at a Single Institute

Cited by 72 publications

References 22 publications

Prevalence and recurrence rate of colonic lesions in acromegalic patients

Prevalence and recurrence rate of colonic lesions in acromegalic patients

Frequency of various types of neoplasia in a group of acromegalic patients

Poorly-controlled Acromegaly Accompanied by Subclinical Adrenal Cushing's Syndrome after Surgery for Multiple Endocrine Tumors

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