The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes

Domżał-Magrowska, Danuta; Kowalski, Marek; Szcześniak, Piotr; Bulska, M; Orszulak–Michalak, Daria; Małecka‐Panas, Ewa

doi:10.5114/pg.2016.57941

Cited by 14 publications

(12 citation statements)

References 33 publications

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“…Studies with transgenic mice sensitised by gluten demonstrated that human leucocyte antigen DQ8 (HLA-DQ8) show an altered barrier function and enhanced muscle contractility—mechanisms previously observed in IBS patients [ 124 ]. Recently, it was shown that up to 50% of IBS patients have the genetic factors (HLA-DQ2/DQ8) predisposing to gluten sensitivity [ 125 ], which was in line with the findings of Catassi et al in a review of the effectiveness of gluten-free diet in IBS, which identified an overall positive response [ 122 ]. However, a recent RCT involving a gluten challenge showed that 49% of non-celiac gluten-sensitive individuals paradoxically developed symptoms after a gluten-free diet [ 126 ].…”

Section: Diet Bacteria and Ibssupporting

confidence: 66%

The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome

Harper

Naghibi

Garcha

2018

Foods

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Irritable bowel syndrome is a highly prevalent gastrointestinal disorder that threatens the quality of life of millions and poses a substantial financial burden on healthcare systems around the world. Intense research into the human microbiome has led to fascinating discoveries which directly and indirectly implicate the diversity and function of this occult organ in irritable bowel syndrome (IBS) pathophysiology. The benefit of manipulating the gastrointestinal microbiota with diet and probiotics to improve symptoms has been demonstrated in a wealth of both animal and human studies. The positive and negative mechanistic roles bacteria play in IBS will be explored and practical probiotic and dietary choices offered.

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Section: Diet Bacteria and Ibssupporting

confidence: 66%

The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome

Harper

Naghibi

Garcha

2018

Foods

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“…Due to this mimicry, the CD is often misdiagnosed as IBS and increases its morbidity. 20 The mean age in our study was 28.40 + 5.06. Out of 210 patients enrolled, 53.8% were males and 46.2% were females.…”

Section: Discussionmentioning

confidence: 62%

Prevalence of celiac disease in irritable bowel syndrome patients: A single centre experience from a large teaching hospital of Lahore, Pakistan

Saifullah¹,

Khan²,

Zahoor³

et al. 2021

J Fatima Jinnah Med Univ

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Background: Many studies have been conducted worldwide to evaluate the proportion of patients with Celiac disease (CD) in persons presenting with Irritable Bowel Syndrome (IBS), showing a positive association between the two diseases. However, reports from Pakistan remain scanty. This study aims to find out the prevalence of CD in patients presenting with IBS and to establish the correlation of both diseases. Patients and methods: It was a descriptive cross-sectional study conducted at Combined Military Hospital, Lahore (CMHL) from January 2018 till March 2019. Consecutive, nonprobability sampling was used to include 210 patients of both genders with the age range of 15-65 years fulfilling ROME IV criteria and were not previously diagnosed as CD or CKD or CLD. Demographic data was noted. Serum Anti tTG levels and Duodenal Biopsy from the second part was assessed to diagnose CD. CD was labeled if the disease was present on both serological and Histopathological reports. Data were analyzed by using SPSS version 20. Descriptive statistics were calculated and a Chi-square test was used to compare the outcome variables with P-value < 0.05 as significant. Results: Of 210 enrolled patients, 113 (53, 8%) were male and 97 (46.2%) were female. The mean age of the patients was 28.40 ± 5.06 years. Eight patients (3.8%) were positive for Anti tTg and on histopathological findings suggestive of CD. Seven of 8 were less than 35 years old. Out of 8 positive patients, 6 (75%) were females. However, the p-value was found to be insignificant for age (0.549) and gender (0.096). On stratification with respect to duration of IBS, all 8 patients diagnosed with celiac disease were having symptoms of IBS for less than 12 months (100%) which was significant statistically (7.1% vs 0.0%; p=0.007). Conclusion: The frequency of CD was 3.8% among IBS patients. Considering this percentage of CD in IBS patients s, a high index of suspicion for CD in IBS patients is required,

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“…Evaluating data from nearby countries, in Poland CD prevalence among IBS-D patients was high: 7% (serological and histological CD detection) [25] or 12.5% among IBS patients regardless of the subtype (serological and genetical CD detection) [26]. At the same time, low prevalence (0.3% and 0.4%) of the biopsy-proven CD was detected in IBS patients from a high CD prevalence country Norway, all of whom fulfilled the Rome III criteria for IBS-D [5,6].…”

Section: Discussionmentioning

confidence: 99%

Low Prevalence of Celiac Disease among Patients with Functional Gastrointestinal Disorders in Latvia

Dekante

Daugule

Pavlovics

et al. 2020

JGLD

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Background and Aims: Studies suggest that the prevalence of celiac disease (CD) is increased in individuals with functional gastrointestinal disorders (FGIDs), in particular, irritable bowel syndrome (IBS); however, the evidence is conflicting. We aimed to analyze the prevalence of CD in patients with FGIDs in Latvia. Methods: This retrospective study included patients with FGIDs, referred for a gastroenterologist consultation in a secondary gastroenterology practice unit. Patients were divided into three groups – patients only with IBS (IBS group), patients only with functional dyspepsia (FD) (FD group), patients with mixed symptoms IBS and FD (Mixed group). Patient levels of tissue transglutaminase IgA (tTG-IgA) and/or antiendomysial IgA group antibodies (EMA-IgA) were evaluated. Four duodenal biopsies were obtained and reported according to Marsh classification. Patients diagnosed or being referred for confirmation of CD were excluded from the study. Results: Overall, 1,833 FGIDs patients were enrolled. Celiac serology was available for 1,570 patients, duodenal histology for 582 patients, both histology and serology for 319 patients. In total, celiac seropositivity was present in 1.78% (28/1570) (3.18% in IBS group, 0.90% in FD group and 1.11% of cases in the mixed group). Fifteen patients had histopathological changes (2.58%; 15/582). Three IBS patients (2.36%) were both serology and biopsy positive. None of the FD patients had CD. Conclusion: Prevalence of biopsy-proven CD in patients from Latvia with FGIDs was low. Routine screening for CD could be considered only among patients with IBS.

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The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes

Cited by 14 publications

References 33 publications

The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome

The Role of Bacteria, Probiotics and Diet in Irritable Bowel Syndrome

Prevalence of celiac disease in irritable bowel syndrome patients: A single centre experience from a large teaching hospital of Lahore, Pakistan

Low Prevalence of Celiac Disease among Patients with Functional Gastrointestinal Disorders in Latvia

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