The prevalence of celiac disease in average-risk and at-risk Western European populations: A systematic review

Dubé, Catherine; Rostom, Alaa; Sy, Richmond; Cranney, Ann; Saloojee, Navaaz; Garritty, Chantelle; Sampson, Margaret; Zhang, Li; Yazdi, Fatemeh; Mamaladze, Vasil; Pan, Irene; MacNeil, Joanne; Mack, David R.; Patel, Dilip D.; Moher, David

doi:10.1053/j.gastro.2005.02.014

Cited by 527 publications

(393 citation statements)

References 108 publications

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“…3 Indeed, the overall prevalence was substantially higher than previously enumerated. 26 This finding supports a more pro-active screening of FMs in the US. Secondly, carrying HLA-DQ2 and being a sibling of the index case were the greatest risk factors for CD.…”

Section: Discussionsupporting

confidence: 58%

Predictors of Family Risk for Celiac Disease: A Population-Based Study

Rubio–Tapia

Dyke

Lahr

et al. 2008

Clinical Gastroenterology and Hepatology

138

130

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Section: Discussionsupporting

confidence: 58%

Predictors of Family Risk for Celiac Disease: A Population-Based Study

Rubio–Tapia

Dyke

Lahr

et al. 2008

Clinical Gastroenterology and Hepatology

138

130

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“…Genetic predisposition to CD is clearly demonstrated in concordance studies on monozygotic (75%) and dizygotic (10%) twin couples, as well as by the high degree of family grouping of the disease (9) . DQ2 heterodimers are codified in cis by alleles DQA1*0501 and DQB1*0201.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Genetic Susceptibility for Celiac Disease in Blood Donors in São Paulo, Brazil

Muniz

Sdepanian

Neto

2016

Arq. Gastroenterol.

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-Background -Celiac disease is a permanent intolerance induced by gluten, which is expressed by T-cell mediated enteropathy, and has a high prevalence in the general population. There is evidence of a strong genetic predisposition to celiac disease. Objective -To determine the prevalence of genetic markers HLA-DQ2 and HLA-DQ8 in blood donors from São Paulo and measure human recombinant tissue transglutaminase antibody IgA class in HLA-DQ2 and HLA-DQ8 positive donors.Methods -A total of 404 blood donors from São Paulo city and Jundiaí were included in the study and signed the informed consent form. Information regarding diarrhea, constipation and abdominal pain in the last 3 months was collected. Determination of HLADQ2 and HLADQ8 alleles was performed in all participants and human recombinant tissue transglutaminase antibody class IgA was measured only in blood donors who presentedDQ2 and/or DQ8. Results -HLADQ2 and/or HLADQ8 were positive in 49% (198/404) of subjects. Positive samples were associated with alleles DR3, DR4, DR7, DR11 and DR12. The most frequent genotype was DR4-DQ8, which was present in 13.6% of samples, followed by genotypes DR3-DQ2 and DR7-DQ2 with DQB1*02 in heterozygous, which were present in 10.4% and 8.7%, respectively. Eleven out of 198 positive donors (5%) were positive to human tissue transglutaminase test. Conclusion -We observed a high prevalence of genetic markers for celiac disease, HLA-DQ2 and HLA-DQ8, in blood donors from São Paulo, similar to prevalence described in Europe. These findings show that the prevalence of celiac disease should not be rare in our country, but underdiagnosed.

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“…Originally a disease of childhood, CD is now more frequently first diagnosed in adults and has a prevalence of around 1% in Europe and the US (Bingley et al, 2004;Dube et al, 2005;Lohi et al, 2007;West, Logan,Smith, Hubbard & Card, 2003) . This change in presentation is partly explained by the increasing use of serological tests for active case-finding and for targeted screening in high risk groups (Collin, 2005;Hin et al, 1999;Jones, 2007;Karponay-Szabo et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Intentional and inadvertent non-adherence in adult coeliac disease. A cross-sectional survey

2013

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Publisher's copyright statement: NOTICE: this is the author's version of a work that was accepted for publication in Appetite. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be re ected in this document. Changes may have been made to this work since it was submitted for publication. A de nitive version was subsequently published in Appetite, 68, 2013Appetite, 68, , 10.1016Appetite, 68, /j.appet.2013 Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. ABSTRACTAdherence to a gluten-free diet is the mainstay of treatment for coeliac disease. Nonadherence is common as the diet is restrictive and can be difficult to follow. This study aimed to determine the rates of intentional and inadvertent non-adherence in adult coeliac disease and to examine the factors associated with both. A self-completion questionnaire was mailed to adult coeliac patients identified from the computer records of 31 family practices within the North East of England. We received 287 responses after one reminder. Intentional gluten consumption was reported by 115 (40%) of respondents. 155 (54%) had made at least one known mistaken lapse over the same period and 82 (29%) reported neither intentional nor mistaken gluten consumption.Using logistic regression analysis, low self-efficacy, perceptions of tolerance to gluten and intention were found to be independently predictive of intentional gluten consumption. A statistical model predicted 71.8% of cases reporting intentional lapses.Intentional non-adherence to the GFD was found to be common but not as frequent as inadvertent lapses. Distinguishing the factors influencing both intentional and inadvertent non-adherence is useful in understanding dietary self-management in coeliac disease.

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The prevalence of celiac disease in average-risk and at-risk Western European populations: A systematic review

Cited by 527 publications

References 108 publications

Predictors of Family Risk for Celiac Disease: A Population-Based Study

Predictors of Family Risk for Celiac Disease: A Population-Based Study

Prevalence of Genetic Susceptibility for Celiac Disease in Blood Donors in São Paulo, Brazil

Intentional and inadvertent non-adherence in adult coeliac disease. A cross-sectional survey

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