The Prevalence of Cervical HPV and Cytological Abnormalities in Association with Reproductive Factors of Rural Nigerian Women

Schnatz, Peter F.; Markelova, Natalia V.; Holmes, Danielle; Mandavilli, Srinivas; O’Sullivan, David

doi:10.1089/jwh.2006.0295

Cited by 29 publications

(31 citation statements)

References 27 publications

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“…This is similar to a study done by Schartz et al in Okene central Nigeria which found a prevalence of 19.7% [6]. The prevalence of HR-HPV in the study done in Ibadan by Thomas et al was 16.6%.…”

Section: Discussionsupporting

confidence: 90%

Prevalence of High Risk Oncogenic Human Papillomavirus Types in Cervical Smears of Women Attending Well Woman Clinic in Ile Ife, Nigeria

GO¹

2013

Gynecol Obstet (Sunnyvale)

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This study is aimed at estimating the prevalence of cervical infection with High risk Human Papillomavirus (HR-HPV) in cervical smears of women attending the Well Woman Clinic of the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife. This is a community based clinic where women are screened for cervical, breast and other female related diseases. This is a prospective cross-sectional observational study. Information was obtained through personal interviews using structured questionnaire. Cervical samples were collected from 118 consenting women visiting the clinic during the study period. Conventional Pap smear was obtained and smear results were classified using Bethesda classification, 2001.HPV DNA was detected using the hybribio 21 HPV Geno array test kit which uses Polymerase Chain Reaction (PCR), amplification and flow through hybridization.The data obtained were analyzed using simple and inferential statistics.The mean age of the participants was 42.9 years (SD ± 10.9). A total of nine different HR-HPV types were identified with an HPV prevalence of 21.6% overall and 22.7% among women with cervical lesions. The predominant HR-HPV types were HPV 16, 53, 18 and 52. In all, 41.7% of the infections involved more than one HPV type. Unlike in most populations studied so far, HPV prevalence was high not only among young women, but also in middle and old age. It was also observed that the prevalence of HR-HPV increases with parity.This study shows that HPV 53 is the second most common type after HPV 16 in our environment. High prevalence of HR-HPV in all age group may be a distinctive feature of our population of women where HPV transmission continues into the middle age and cervical cancer incidence is very high.

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Section: Discussionsupporting

confidence: 90%

Prevalence of High Risk Oncogenic Human Papillomavirus Types in Cervical Smears of Women Attending Well Woman Clinic in Ile Ife, Nigeria

GO¹

2013

Gynecol Obstet (Sunnyvale)

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“…The low-risk HPV were found in 6.6% and mixed infections of more than one HPV type occurred in 33.5% of HPV-positive cases. A similar incidence of 21.6% was found in Okene, north-central Nigeria with the high-risk HPV prevalence of 16.6 and 3.5% having mixed infections [19].…”

Section: Burden Of Hpv Infection and Regional Variation Of Genotypessupporting

confidence: 70%

Cervical Cancer, a Sequela of a Sexually Transmitted Infection: The Human Papillomavirus Infection

Nyengidiki¹,

Bassey²,

Ikechukwu³

2017

Fundamentals of Sexually Transmitted Infections

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“…Besides, there was no statistically significant difference in the mean age of women diagnosed with HPV in a study conducted in a rural area at Okene North central Nigeria [20] . Akarolo-Anthony and colleagues observed in their study in an urban area in Abuja a significant inverse linear association between age and the prevalence of HPV infections.…”

Section: Hpv and Age In Nigeriamentioning

confidence: 80%

“…However, no general public [15][16][17][18][19][20] . It is worthy of note that even in the report of the Information Centre on HPV and Cancer held August 22 nd , 2014, data on Human Papillomavirus [5] was generalized based on national prevalence figure gotten from studies done at Ile-Ife, Ibadan and Okenne respectively [17, 18 & 20] .…”

Section: Particularly High Prevalence Is Seen Inmentioning

confidence: 99%

“…These differences may depend on various factors such as; study design (population based studies or hospital based cross-sectional studies) for example similarities exists in population based studies from Ibadan and Irun respectively [17,18] , type of molecular assay implored in the study [17][18][19][20][30][31][32][33][34] (all the studies in this review used different molecular assays), presence of a co-infection like HIV [32,34] , size of the sampled population and nature of the sampled population (rural or urban) [18,31] .…”

Section: Hpv and Age In Nigeriamentioning

confidence: 99%

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The Burden of Human Papillomavirus Infections Among Women in Nigeria: A Review Update

Omoare¹,

Ashaka²,

Nasir³

et al. 2016

J. Appl. Virol.

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Human Papillomavirus has been long implicated as a necessary cause of cervical cancer in which 80% of the disease burden occurs in developing countries where organized cytology based programmes have not been feasible. In Nigeria, it is estimated that 14,089 women are diagnosed with cervical cancer annually. This review, selected publications on HPV related cervical cancer across Nigeria where proper quality controlled molecular methods were used for diagnosis. Different genotypes of high risk HPV have been detected with variations across populations. HPV types found associated with women in Nigeria included types; 16,18,31,33,35,52,56 and 68 in disproportionate distribution with cases of multiple infections. There is a need for more population based studies to ascertain specific HPV genotypes common to specific population and the need for the development of multivalent therapeutic vaccines over the present prophylactic bivalent or quadrivalent vaccines which does not prevent against all oncogenic HPV genotypes.

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The Prevalence of Cervical HPV and Cytological Abnormalities in Association with Reproductive Factors of Rural Nigerian Women

Abstract: The prevalence of cervical HPV and SIL in Okene, Nigeria, is consistent with reports from other African regions. Improved access to healthcare and cervical cancer screening programs may help to decrease transmission of HPV and subsequent cervical cancer in underprivileged areas.

Cited by 29 publications

References 27 publications

Prevalence of High Risk Oncogenic Human Papillomavirus Types in Cervical Smears of Women Attending Well Woman Clinic in Ile Ife, Nigeria

Prevalence of High Risk Oncogenic Human Papillomavirus Types in Cervical Smears of Women Attending Well Woman Clinic in Ile Ife, Nigeria

Cervical Cancer, a Sequela of a Sexually Transmitted Infection: The Human Papillomavirus Infection

The Burden of Human Papillomavirus Infections Among Women in Nigeria: A Review Update

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