The prevalence of childhood atopic eczema in a general population

Kay, Jacob; Gawkrodger, David J.; Mortimer, M.J.; Jaron, A.

doi:10.1016/s0190-9622(94)70004-4

Cited by 443 publications

(257 citation statements)

References 16 publications

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“…Interventions aimed at reducing exposure to or harmful sequelae from environmental triggers of AD could prevent or mitigate disease. The prevalence of AD appears to be higher in wealthier, developed regions compared with developing regions [2,[35][36][37][38][39][40][41][42][43][44]. Moreover, the prevalence of AD dramatically increased over the past 50 years worldwide and continues to increase in a number of countries [1,45].…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: Environmental Risk Factorsmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

View full text Add to dashboard Cite

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“…89 It is characterized by an overactive Th2 ( § T22/Th17) 79,90 dermal immune response to a host of environmental allergens and the entire skin surface appears dry or xerotic. Recent evidence suggests that both features are due in part to an epidermal barrier defect.…”

Section: Tj Abnormalities In Human Skin Disordersmentioning

confidence: 99%

Epidermal tight junctions in health and disease

et al. 2014

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“…Likewise, atopic dermatitis (AD) is a common disorder with a lifetime prevalence of 15-20% (1,2). Recent studies show increasing prevalence of asthma and AD in Western countries including Denmark (3)(4)(5).…”

mentioning

confidence: 99%

Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children – a prospective cohort study

Larsen¹,

Schlünssen²,

Christensen³

et al. 2014

Scand J Work Environ Health

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Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children -a prospective cohort study by Larsen AD, Schlünssen V, Christensen BH, Bonde JP, Obel C, Thulstrup AM, Hannerz H, Hougaard KS Literature suggests a relationship between maternal stress exposure and risk of asthma and atopic dermatitis (AD) among children; so far no studies have focused on maternal job strain. Based on the prospective Danish National Birth Cohort, results show: maternal exposure to high strain jobs was associated with AD, whereas active jobs were associated with asthma among 7-year old children. Affiliation 639Original article Scand J Work Environ Health. 2014;40(6):639-648. doi:10.5271/sjweh.3452 Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children -a prospective cohort study Objectives Few epidemiological studies have studied maternal stress exposure during pregnancy and odds of asthma and atopic dermatitis (AD) among offspring, and none have extended the focus to psychosocial job strain. The aim of this study was to assess the association between maternal job strain during pregnancy and asthma as well as AD among 7-year-old children. MethodsThe study is based on the Danish National Birth Cohort and includes prospective data from 32 104 pregnancies. Job strain was assessed early in pregnancy by use of two questions on demands and control. We categorized participants into four job strain categories: low strain (low demands, high control), active (high demands, high control), passive (low demands, low control), and high strain (high demands, low control). Information on asthma and AD until age seven was collected using maternal self-report. Multinomial logistic regression models were used to estimate odds ratios (OR) with 95% confidence intervals (95% CI) adjusted for several covariates.Results Maternal exposure to self-reported high strain during pregnancy was associated with 15% higher odds of atopic dermatitis among 7-year-old children (OR adj 1.15, 95% CI 1.02-1.31). Furthermore, an association between the active jobs and asthma among 7-year-old children was found (OR adj 1.13, 95% CI 1.03-1.24). ConclusionMaternal exposure to high strain and active jobs during pregnancy was associated with asthma and atopic dermatitis among 7-year-old children.

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The prevalence of childhood atopic eczema in a general population

Cited by 443 publications

References 16 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Epidermal tight junctions in health and disease

Exposure to psychosocial job strain during pregnancy and odds of asthma and atopic dermatitis among 7-year old children – a prospective cohort study

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