The prevalence of coagulase-negative staphylococcus associated with bovine mastitis in China and its antimicrobial resistance rate: a meta-analysis

Abstract

To contribute to the treatment decision and optimize coagulase-negative staphylococcus (CNS) control programs, we conducted a meta-analysis to investigate the epidemiology and antimicrobial resistance rates of coagulase-negative staphylococcus associated with bovine mastitis in China. Three databases (PubMed, Google scholar and China National Knowledge Infrastructure database) were utilized to obtain relevant publications. A total of 18 publications were included in our research, and 3 of them included antimicrobial resistant (AMR) test. The pooled prevalence of coagulase-negative staphylococcus was 17.28%. Subgroup analysis revealed that the prevalence was higher in South China than in North China, was higher in 2011–2020 than in 2000–2010 and was higher in clinical bovine mastitis cases than in subclinical cases. The pooled AMR were most resistant to β-lactams, followed by tetracyclines, quinolones, nitrofurans, lincosamides, sulfonamides, amphenicol and aminoglycosides. The pooled AMR rate of coagulase-negative staphylococcus was lower in 2011–2020 than in 2000–2010. Although the prevalence of CNS showed an increasing trend over 20 years, the AMR rate showed a decreasing trend, and the clinical type of mastitis was the most frequent and the prevalence was highest in South China. Finally, CNS was most resistant to β-lactams amongst the eight groups of antimicrobial agents.

Prevalence, Virulence, and Antimicrobial Resistance of Major Mastitis Pathogens Isolated from Taiwanese Dairy Farms

“…Tetracycline is the most widely used antibiotic globally to treat various infections in cattle, including Taiwan, due to its broad-spectrum effectiveness, which may be the reason for the widespread resistance against tetracycline. The efflux pump is the most important mechanism of bacterial antimicrobial resistance to tetracycline, although ribosomal protective protein and enzyme inactivation also have a role in resistance development [21]. Aminoglycosides (neomycin) are used for prophylactic purposes in dairy animals, but they are not an effective antimicrobial agent for the treatment of mastitis-causing Streptococcus bacteria because most streptococci have inherited resistance to this class of antimicrobial due to their poor ability to penetrate the cell walls of bacteria [22].…”