The prevalence of comorbid depression in patients with type 2 diabetes: an updated systematic review and meta-analysis on huge number of observational studies

Khaledi, Mohammad; Haghighatdoost, Fahimeh; Feizi, Awat; Aminorroaya, Ashraf

doi:10.1007/s00592-019-01295-9

Cited by 243 publications

(215 citation statements)

References 239 publications

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“…Epidemiologic studies have reported that the worldwide prevalence of diabetes mellitus is expected to increase from 425 million in 2017 to an estimated 629 million in 2045 (2). Both cross-sectional and longitudinal studies reported that T2DM is associated with Alzheimer's disease (AD) (3), mild cognitive impairment (MCI) (4), anxiety, and depression (5). Diabetes-associated cognitive decline (DACD), a series of slight cognitive decrements over time, is generally thought to be a central nervous system (CNS) complication of T2DM (6,7).…”

Section: Introductionmentioning

confidence: 99%

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Zhan

Zhou

et al. 2020

Front. Psychiatry

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Background: Cognitive impairment is a complication of type 2 diabetes mellitus (T2DM) that affects the central nervous system (CNS). Studies have shown that chronic psychological stress may promote the development of T2DM into diabetes-associated cognitive decline (DACD). Previously, cognitive impairment in T2DM was correlated predominantly with insulin resistance in the medial prefrontal cortex (mPFC). Aims:We examined the effect of the ZiBuPiYin recipe (ZBPYR) on Zucker diabetic fatty (ZDF) rats and explored the impact of chronic stress on altered b-amyloid (Ab) metabolism through insulin receptor substrate (IRS) 1/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway after the induction of chronic psychological stress.Main Methods: After chronic psychological stress and drug treatment, cognitive function was observed via behavioral experiments. The activation of the hypothalamus-pituitaryadrenal (HPA) axis and levels of Ab were detected by enzyme-linked immunosorbent assay, and the expression of related proteins was evaluated by Western blotting.Key Findings: ZBPYR treatment significantly decreased anxious-like behaviors and plasma corticosterone (CORT) levels, and ameliorated learning and memory impairments of ZDF rats after chronic psychological stress. ZBPYR also reduced the deposition of Ab in the mPFC, improved brain insulin resistance, and modulated the mTOR-autophagy pathway.Significance: ZBPYR may be a potential therapeutic application for the treatment of DACD induced by chronic psychological stress.

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Section: Introductionmentioning

confidence: 99%

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Zhan

Zhou

et al. 2020

Front. Psychiatry

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“…Type 2 diabetes, like other chronic diseases, is associated with an increased risk of comorbid health problems, including depression. Authors of a meta-analysis based on 248 studies and 83,020,812 participants reported that 28% of adults with T2D had a co-occurring depressive disorder [4]. People with T2D are twice as likely to develop depression, compared with the general population [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Association between subthreshold depression and self-care behaviors in people with type 2 diabetes: a systematic review of observational studies

Shrestha

Al-Ghareeb³

et al. 2020

Syst Rev

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Background: Self-care behaviors in people living with type 2 diabetes are important to achieving optimal glycemic control. Major depression in type 2 diabetes is associated with decreased adherence to self-care behaviors. The association between subthreshold depression and self-care behaviors, however, has not previously been systematically reviewed. The objective of this review is to determine the association between subthreshold depression and self-care behaviors. Methods: A systematic search was performed in five electronic databases that included MEDLINE, EMBASE, PsycINFO, Emcare, and CINAHL. Any observational studies in adults with type 2 diabetes, investigating the association between subthreshold depression and any self-care behaviors, were included in the review. Qualitative studies, review articles, and gray literature were excluded. Two reviewers independently completed the title and abstract and full-text screening, appraised the study quality, and extracted the data. A third reviewer resolved any discrepancies between the reviewers if needed. Included articles were critically appraised using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Meta-analyses were not conducted because criteria for conducting such analyses were not met. Results: A total of 6408 articles were identified through the database searching. After the abstract and full-text review, two articles met the inclusion criteria. One of the included study was cross-sectional while the other was a longitudinal study. Both studies showed inconsistent findings in the association between subthreshold depression and self-care behaviors. Important risks of bias were identified in the included studies. Discussion: The evidence from the two included studies on a possible association between subthreshold depression and self-care behaviors in adults with type 2 diabetes was not consistent and potentially biased. Our review established a gap in knowledge and suggests that further high-quality studies are needed to examine the association between subthreshold depression and self-care behaviors in people with type 2 diabetes. Systematic review registration: PROSPERO CRD42018116373

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“…Results of several developing countries' epidemiological studies showed the prevalence of depression in T2DM ranged from 34% to 54% [19][20][21] . 28% T2DM patients have depression at different degrees [22] , and 14.5% have major depressive disorder [23] . In China, relevant epidemiological investigations have also been carried out in quantity.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Depression in Chinese Patients With Type 2 Diabetes Mellitus: a Protocol of Systematic Review and Meta-analysis

LIU

Chen²,

Jiang³

et al. 2020

Preprint

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Background: The prevalence of type 2 diabetes mellitus (T2DM) is growing in China. Both physical and psychological complications occur along with the development of T2DM. The patients with depression account for a significant proportion of T2DM. Depressive symptoms interfere with blood glucose management, leading to poorer treatment outcome and even relate to the occurrence of other serious complications of T2DM population. Among these T2DM patients with depression, early detection and treatment is essential and effective. Knowledge of the current prevalence of depression in T2DM patients as well as associated risk factors may be meaningful for healthcare planning. Therefore, we plan to conduct a systematic review and meta-analysis to evaluate the Chinese prevalence of depression in T2DM and explore associated risk factors.Methods: We will search literatures recorded in MEDLINE/PubMed, EMBASE, the Cochrane Library, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and Wanfang database (Wanfang Data). The grey literatures and reference list will be manually searched. We will include population-based, cross-sectional surveys that investigated the Chinese prevalence of depression in T2DM or/and researched the possible risk factors. Two reviewers will screen studies, extract data and evaluate quality independently. We will assess inter-rater agreement between reviewers for study inclusion, data extraction, and study quality assessment using Kappa statistics. The primary outcome will be the pooled Chinese prevalence of depression in T2DM patients. The secondary outcome will contain the potential risk factors for depression in patients with T2DM. R software (version 3.6.1) and STATA software (version 12) will be used for data analysis.Discussion: This systematic review will provide comprehensive evidence of the Chinese prevalence and risk factors of depression in patients with T2DM. we expect to provide evidence basis for healthcare practitioners and policy makers to pay attention to the mental health of T2DM. Our data will highlight the need and importance of early detection and intervention for depression in patients with T2DM. Systematic review registration: PROSPERO CRD42020182979.

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The prevalence of comorbid depression in patients with type 2 diabetes: an updated systematic review and meta-analysis on huge number of observational studies

Cited by 243 publications

References 239 publications

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Association between subthreshold depression and self-care behaviors in people with type 2 diabetes: a systematic review of observational studies

Prevalence and Risk Factors of Depression in Chinese Patients With Type 2 Diabetes Mellitus: a Protocol of Systematic Review and Meta-analysis

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