2012
DOI: 10.1089/aid.2011.0097
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The Prevalence of Drug Resistance Mutations Among Treatment-Naive HIV-Infected Individuals in Beijing, China

Abstract: To investigate the prevalence of HIV-1 genotypic mutations for drug resistance among patients in Beijing, blood samples from 145 newly confirmed (2006-2007), treatment-naive HIV-1-infected individuals were analyzed. Seven subtypes or CRF were subsequently determined and scored by the Stanford HIV Drug Resistance algorithm: CRF01_AE HIV-1 (27.6%), subtype B' (24.1%), CRF07_BC (21.4%), subtype B (20.7%), CRF08_BC (3.4%), subtype C (2.1%), and CRF06_cpx (0.7%). Eleven of the 145 subjects studied were found to har… Show more

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Cited by 17 publications
(13 citation statements)
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“…Even if the minor mutations are excluded, there are 14 (14.3%, 14 of 98) sequences associated with significantly reduced phenotypic susceptibility to antiretroviral drugs, still higher than the 3.8% HIV drug resistance rate among 676 treatment-naive HIV patients in a nationwide investigation 16 and the 7.6% among 145 antiretroviral-naive patients from 2006 to 2007 in Beijing. 17 And the percentage is similar to the 12% HIV drug resistance rate reported for 55 HIV-1 newly diagnosed and treatment-naive patients recruited from 2010 to 2011. 18 In conclusion, the present study demonstrates that subtype B¢ is the predominant HIV subtype and detected a relatively high prevalence of TDR mutations among antiretroviral-naive individuals in Henan province.…”
supporting
confidence: 74%
“…Even if the minor mutations are excluded, there are 14 (14.3%, 14 of 98) sequences associated with significantly reduced phenotypic susceptibility to antiretroviral drugs, still higher than the 3.8% HIV drug resistance rate among 676 treatment-naive HIV patients in a nationwide investigation 16 and the 7.6% among 145 antiretroviral-naive patients from 2006 to 2007 in Beijing. 17 And the percentage is similar to the 12% HIV drug resistance rate reported for 55 HIV-1 newly diagnosed and treatment-naive patients recruited from 2010 to 2011. 18 In conclusion, the present study demonstrates that subtype B¢ is the predominant HIV subtype and detected a relatively high prevalence of TDR mutations among antiretroviral-naive individuals in Henan province.…”
supporting
confidence: 74%
“…Such a low prevalence of HIVDR has also been observed in many regions in China [12][13][14][15][16][17][18][19][20][21][22][23]. It should be noted that the prevalence of HIVDR in the present study area was lower than an earlier study (2006)(2007) of 145 treatment-naive HIV patients (7·6%) [15]. A confluence of factors may contribute to such a relatively low prevalence of HIVDR in newly diagnosed or ART-naive HIV patients, for example, the relatively low coverage and short duration of NFATP as well as a success of first-line cART.…”
Section: Discussionmentioning
confidence: 72%
“…China first conducted surveillance of HIVDR in ART-naive HIV-infected individuals in 2004 [12]. By the end of 2012, the prevalence of HIVDR in ART-naive individuals ranged from 1·6% to 12·2% in China [12][13][14][15][16][17][18][19][20][21][22][23][24]. However, such surveillance data are not available for the most developed and populous areas in eastern China where the HIV epidemic is relatively new but rapidly spreading through unprotected heterosexual and homosexual behaviours.…”
Section: Introductionmentioning
confidence: 99%
“…However, many CRF01_AE sequences from the Liaoning heterosexual population7 have close phylogenetic links to MSM cluster 2. Additionally, a few CRF01_AE sequences from Yunnan30 or Guangxi28 infected cases with unknown transmission route and the heterosexual population in Liaoning7 and Beijing23 and Jiangsu IDUs31 were closely related to MSM cluster 1 (Fig. 1A).…”
Section: Discussionmentioning
confidence: 99%