The Prevalence of Dry Eye and Sjögren Syndrome in Patients with Migraine

Saraç, Özge; Kösekahya, Pınar; Tasci, Yelda Yildiz; Keklikoğlu, Hava Dönmez; Denız, Orhan; Erten, Şükran; Çağıl, Nurullah

doi:10.3109/09273948.2015.1132739

Cited by 19 publications

(6 citation statements)

References 37 publications

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“…Several studies have found that patients with migraine are more likely to report dry eye symptoms than controls 13–15 and that severity of dry eye symptoms correlates with migraine severity. 8 Interestingly, some studies have reported that dry eye symptoms correlate with dry eye signs, such as decreased tear break-up times and reduced Schirmer’s testing, 1415 while others have not found such significant differences. 13 Despite mixed evidence, these two disease entities are clearly associated with one another.…”

Section: Discussionmentioning

confidence: 99%

Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

et al. 2018

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Background: To evaluate the efficacy of botulinum toxin A (BoNT-A) in reducing photophobia and dry eye symptoms in individuals with chronic migraine. Additionally, we aimed to evaluate tear film volume as a potential contributor to symptoms in these patients. Methods: Retrospective review of seventy-six patients who received BoNT-A for chronic migraine (CM) between August 23, 2017 and December 13, 2017 at the Miami Veterans Affairs Medical Center Neurotoxin Clinic. Demographic data and all co-morbidities were queried via chart review. Standardized validated surveys were administered to assess symptoms prior to and after BoNT-A injection. Pre-injection tear volumes were obtained using the phenol red thread (PRT) test. Results: Pre-injection migraine, photophobia, and dry eye symptom scores were all significantly correlated, p<0.05; and none were associated with pre-injection PRT results. After BoNT-A, improvements in migraine, photophobia, and dry eye symptoms were also significantly correlated, p<0.05; and similarly did not associate with pre-injection PRT results. Photophobia scores significantly improved following BoNT-A, while dry eye symptoms significantly improved in those with severe symptoms at baseline (DEQ-5 score ≥12), p=0.027. In logistic regression analysis of all individuals with dry eye symptoms (DEQ-5≥6), individuals with more severe dry eye symptoms were more likely improve, OR 1.27, 95% confidence interval [1.06, 1.51], p<0.01. Conclusions: BoNT-A significantly improved photophobia in patients being treated for migraine and also improved dry eye symptoms in patients with severe symptoms at baseline, independent of baseline tear film volume. These improvements may be due to modulation of shared trigeminal neural pathways.

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Section: Discussionmentioning

confidence: 99%

Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

et al. 2018

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“…More recently, Sarac et al observed a higher prevalence of dry eye in 50 migraine patients compared to age- and sex-matched healthy subjects. The authors speculated that dryness of the ocular surface may activate the trigeminal nerve to cause reflex lacrimation, and the activation of the trigeminal nerve may trigger migraine headache [ 207 ].…”

Section: Headache and Connectivitismentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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Several lines of evidence support a role of the immune system in headache pathogenesis, with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte subsets have been reported in headache patients. Secondly, several genetic and environmental pathogenic factors seem to be frequently shared by headache and immunological/autoimmune diseases. Accordingly, immunological alterations in primary headaches, in particular in migraine, have been suggested to predispose some patients to the development of immunological and autoimmune diseases. On the other hand, pathogenic mechanisms underlying autoimmune disorders, in some cases, seem to favour the onset of headache. Therefore, an association between headache and immunological/autoimmune disorders has been thoroughly investigated in the last years. The knowledge of this possible association may have relevant implications in the clinical practice when deciding diagnostic and therapeutic approaches. The present review summarizes findings to date regarding the plausible relationship between headache and immunological/autoimmune disorders, starting from a description of immunological alteration of primary headaches, and moving onward to the evidence supporting a potential link between headache and each specific autoimmune/immunological disease.

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“…Among previous investigations regarding the link between DED and migraine headaches, some have demonstrated an association between the 2 disorders . Objective and clinical variables used to assess the presence and severity of DED, such as tear osmolarity, tear film breakup time, and Schirmer testing results, can also differ significantly between patients with migraine headaches and control individuals without the disorder .…”

Section: Introductionmentioning

confidence: 99%

“…5 Among previous investigations regarding the link between DED and migraine headaches, some have demon-strated an association between the 2 disorders. 6,7 Objective and clinical variables used to assess the presence and severity of DED, such as tear osmolarity, tear film breakup time, and Schirmer testing results, can also differ significantly between patients with migraine headaches and control individuals without the disorder. [8][9][10] Although prior studies in this area shed some light on the possible link between migraine headaches and DED, they possess inherent limitations.Such studies, including some of those cited above, 2,7 are population-based cross-sectional studies that rely on patientreported, subjective assessments of disease symptoms, such as questionnaires or surveys.…”

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confidence: 99%

Association Between Dry Eye Disease and Migraine Headaches in a Large Population-Based Study

et al. 2019

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ry eye disease (DED) is a disorder affecting a significant proportion of the general population, with estimated prevalence rates ranging from 7.4% to 33.7%. 1-3 This multifactorial disorder of the tear film and ocular surface results in symptoms of discomfort, visual disturbance, increased tear film osmolarity, and tear film instability, all of which can lead to inflammation of the ocular surface and a diminished quality of life. 4 Similar to DED, the prevalence of migraine headaches among the general population is also quite high, with estimates as high as 14.2% in the United States alone. 5 Among previous investigations regarding the link between DED and migraine headaches, some have demonstrated an association between the 2 disorders. 6,7 Objective and clinical variables used to assess the presence and severity of DED, such as tear osmolarity, tear film breakup time, and Schirmer testing results, can also differ significantly between patients with migraine headaches and control individuals without the disorder. 8-10 Although prior studies in this area shed some light on the possible link between migraine headaches and DED, they possess inherent limitations. Such studies, including some of those cited above, 2,7 are population-based cross-sectional studies that rely on patientreported, subjective assessments of disease symptoms, such as questionnaires or surveys. 7 Those studies that rely on more objective variables when assessing the presence or absence of IMPORTANCE Reports in the literature have conflicting findings about an association between dry eye disease (DED) and migraine headaches. OBJECTIVE To determine the strength of the association between DED and migraine headaches.

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The Prevalence of Dry Eye and Sjögren Syndrome in Patients with Migraine

Abstract: Dry eye symptoms and findings are higher in migraine patients when compared with the healthy subjects without the presence of Sjögren syndrome.

Cited by 19 publications

References 37 publications

Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

Photophobia and sensations of dryness in patients with migraine occur independent of baseline tear volume and improve following botulinum toxin A injections

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Association Between Dry Eye Disease and Migraine Headaches in a Large Population-Based Study

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