The prevalence of frailty in patients on hemodialysis: a systematic review and meta-analysis

Zhao, Yaxi; Liu, Qinyu; Jie, Jing

doi:10.1007/s11255-019-02310-2

Cited by 29 publications

(18 citation statements)

References 26 publications

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“…Importantly, this review revealed that the prevalence of frailty in ESRD patients on hemodialysis was approximately 43%. Our finding was similar to a recent meta-analysis [42] that showed a 34% prevalence of frailty in patients undergoing hemodialysis. A systematic review by Chowdhury et al also confirmed that the prevalence of frailty in dialysis patients was higher compared to non-dialysis patients [43].…”

Section: Discussionsupporting

confidence: 92%

Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Lee

Son

2021

IJERPH

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Hemodialysis is the most common type of treatment for end-stage renal disease (ESRD). Frailty is associated with poor outcomes such as higher mortality. ESRD patients have a higher prevalence of frailty. This systematic review and meta-analysis aimed to identify the prevalence and associated factors of frailty and examine whether it is a predictor of mortality among ESRD patients undergoing hemodialysis. Five electronic databases including PubMed, Embase, CINAHL, Web of Science, and Cochrane Library were searched for relevant studies up to 30 November 2020. A total of 752 articles were found, and seven studies with 2604 participants in total were included in the final analysis. The pooled prevalence of frailty in patients with ESRD undergoing hemodialysis was 46% (95% Confidence interval (CI) 34.2−58.3%). Advanced age, female sex, and the presence of diabetes mellitus increased the risk of frailty in ESRD patients undergoing hemodialysis. Our main finding showed that patients with frailty had a greater risk of all-cause mortality compared with those without (hazard ratio (HR): 2.02, 95% CI: 1.65−2.48). To improve ESRD patient outcomes, healthcare professionals need to assess the frailty of older ESRD patients, particularly by considering gender and comorbidities. Comprehensive frailty screening tools for ESRD patients on hemodialysis need to be developed.

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Section: Discussionsupporting

confidence: 92%

Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Lee

Son

2021

IJERPH

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“…Currently available anticoagulation methods for CRRT include the following categories: standard dose unfractionated heparin, regional citrate anticoagulation, low molecular weight heparin and heparinoid, regional heparinized anticoagulation, no anticoagulant, thrombin receptor antagonists, and platelet inhibitors, but no one anticoagulant regimen is suitable for all patients treated with CRRT, and the choice of anticoagulation regimen should be individualized. Among a variety of anticoagulants, heparin is easy to use, economical, easy to monitor, and can antagonize protamine when overdose, it is currently the most widely used anticoagulant for CRRT [ 2 ]. Heparin is an anionic sulfated mucopolysaccharide with a molecular weight of 5 kDa to 100 kDa, it forms complexes with antithrombin III in the blood, and the serine proteases of blood coagulation factors I, IX, XI, and XII lead to the rapid inactivation of these factors and plays an anticoagulant effect.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics and Mathematical Analysis of Curative Effect of Hemodialysis in Curing Poisoning Caused by Snakebite

Huang

Chen

Luo³

et al. 2022

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In order to explore the clinical characteristics of hemodialysis in curing poisoning from snakebites, a two-classification model of nuclear logistic neural network based on restricted Boltzmann machine is proposed. The model combines kernel logistic regression with artificial neural networks, enabling the model to both learn autonomously and handle linearly inseparable problems. The network first performs feature learning through unsupervised training of restricted Boltzmann machines and obtains the initial values of the parameters to be identified, which reduces the influence of the randomness of the initial parameters. The variable universe learning rate with scaling factor is used to learn the parameters to be identified, and the model convergence speed is improved by dynamic adjustment of the learning rate. Experimental results show the following: Compared with before treatment, patient’s activated partial thromboplastin time (APTT) after treatment and the prothrombin time (PT) level decrease, fibrinogen (FIB) levels are elevated, aspartate transferase (AST) and creatine kinase isoenzyme (CK-MB) level decreased, and the differences were statistically significant ( p < 0.05 ). It is proved that continuous hemodiafiltration combined with plasma exchange treatment can effectively improve the blood coagulation index and myocardial index of severe snakebite poisoning patients.

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“…8 Therefore, it is of great significance to analyze the related factors affecting the quality of life of MHD patients. 9 In the MHD patients, serious degradation of bodily functions and self-care abilities, increase in complications, and the continuous development of corresponding symptoms, associated with the old age, seriously affect the quality of life. In a clinical study, Zhang L et al 10 showed that age is one of the main factors affecting quality of life of MHD patients.…”

Section: Discussionmentioning

confidence: 99%

Analysis of quality of life and risk factors in 122 patients with persistent hemodialysis

Xie¹,

Song²

2022

Pak J Med Sci

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Objectives: To summarize existing evidence on the quality of life and influencing factors in maintenance hemodialysis (MHD) patients. Methods: Total 122 MHD patients treated in the department of hemodialysis, Liyang branch of Jiangsu Provincial People’s Hospital from January 2018 to June 2020 were selected as the patient group. and 98 healthy persons in the same period were selected as the control group. The quality of life of the two groups was investigated by SF-36 score scale. At the same time, the clinical data of the patient group were investigated. Influencing factors of patients’ quality of life were analyzed by univariate test, and independent risk factors were analyzed by logistic multiple regression. Results: Univariate analysis showed that age, education, marital status, dialysis time, urea clearance index (Kt/V), income level, diabetic nephropathy, nutritional status, medical insurance type, depression and anxiety were single factors influencing the quality of life of MHD patients (P<0.05). Logistic multiple regression analysis showed that age ≥ 60 years, dialysis time ≥ one year, income less than 3000 yuan/month, primary disease is diabetic nephropathy., low medical insurance reimbursement, depression and anxiety were independent risk factors affecting the quality of life of MHD patients (P < 0.05). Conclusions: There was a relatively high proportion of patients with age ≥ 60 years, dialysis time ≥ one year, income less than 3000 yuan/month, primary disease is diabetic nephropathy, low medical insurance reimbursement, depression and anxiety. Timely nursing interventions such as reasonable nutritional support, comprehensive monitoring and psychological counseling for patients with the above situation may be helpful in improving quality of life of MHD patients. doi: https://doi.org/10.12669/pjms.38.4.5308 How to cite this:Xie J, Song C. Analysis of quality of life and risk factors in 122 patients with persistent hemodialysis. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.5308 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The prevalence of frailty in patients on hemodialysis: a systematic review and meta-analysis

Cited by 29 publications

References 26 publications

Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Prevalence and Associated Factors of Frailty and Mortality in Patients with End-Stage Renal Disease Undergoing Hemodialysis: A Systematic Review and Meta-Analysis

Clinical Characteristics and Mathematical Analysis of Curative Effect of Hemodialysis in Curing Poisoning Caused by Snakebite

Analysis of quality of life and risk factors in 122 patients with persistent hemodialysis

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