The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children

Claret, Gemma; Noguera, Antoni; González-Cuevas, Araceli; García‐García, Juan José; Fortuny, Clàudia; Muñoz-Almagro, Carmen

doi:10.1007/s00431-007-0624-7

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Third, HPgV-2 viremia was not as prevalent as HPgV-1 viremia in all of the groups tested (Table 1, S1 Table). We found HPgV-1 in 9.5% of HCV-infected individuals and in 4.2% of volunteer blood donors, comparable with other reports [24][25][26][27][28][29], while HPgV-2 viremia was 1.1% in HCV-infected individuals (p < 0.0001 versus HPgV-1 viremia) and absent in volunteer donors (p < 0.0001). This difference in prevalence may reflect differences in the mode or efficiency of HPgV-2 transmission relative to HCV and HPgV-1.…”

Section: Discussionsupporting

confidence: 91%

Discovery of a Novel Human Pegivirus in Blood Associated with Hepatitis C Virus Co-Infection

Berg¹,

Lee²,

Coller³

et al. 2016

Journal of Hepatology

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Hepatitis C virus (HCV) and human pegivirus (HPgV), formerly GBV-C, are the only known human viruses in the Hepacivirus and Pegivirus genera, respectively, of the family Flaviviridae. We present the discovery of a second pegivirus, provisionally designated human pegivirus 2 (HPgV-2), by next-generation sequencing of plasma from an HCV-infected patient with multiple bloodborne exposures who died from sepsis of unknown etiology. HPgV-2 is highly divergent, situated on a deep phylogenetic branch in a clade that includes rodent and bat pegiviruses, with which it shares <32% amino acid identity. Molecular and serological tools were developed and validated for high-throughput screening of plasma samples, and a panel of 3 independent serological markers strongly correlated antibody responses with viral RNA positivity (99.9% negative predictive value). Discovery of 11 additional RNA-positive samples from a total of 2440 screened (0.45%) revealed 93-94% nucleotide identity between HPgV-2 strains. All 12 HPgV-2 RNA-positive cases were identified in individuals also testing positive for HCV RNA (12 of 983; 1.22%), including 2 samples co-infected with HIV, but HPgV-2 RNA was not detected in non-HCV-infected individuals (p<0.0001), including those singly infected by HIV (p = 0.0075) or HBV (p = 0.0077), nor in volunteer blood donors (p = 0.0082). Nine of the 12 (75%) HPgV-2 RNA positive samples were reactive for antibodies to viral serologic markers, whereas only 28 of 2,429 (1.15%) HPgV-2 RNA negative samples were seropositive. Longitudinal sampling in two individuals revealed that active HPgV-2 infection can persist in blood for at least 7 weeks, despite the presence of virus-specific antibodies. One individual harboring both HPgV-2 and HCV RNA was found to be seronegative for both viruses, suggesting a high likelihood of simultaneous acquisition of HCV and HPgV-2 infection from an acute co-transmission event. Taken together, our PLOS Pathogens |

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Section: Discussionsupporting

confidence: 91%

Discovery of a Novel Human Pegivirus in Blood Associated with Hepatitis C Virus Co-Infection

Berg¹,

Lee²,

Coller³

et al. 2016

Journal of Hepatology

View full text Add to dashboard Cite

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“…HCV‐positive individuals are often coinfected with another flavivirus, GBV‐C, likely reflecting similarities in their mode of transmission 50,86‐95 . The detection of GBV‐C RNA in 25% of the HCV‐seropositive donors was therefore anticipated.…”

Section: Discussionmentioning

confidence: 99%

Transfusion transmission of highly prevalent commensal human viruses

et al. 2010

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GBV-C/HIV-1 coinfection is associated with low HIV-1 viral load and high CD4+ T lymphocyte count

et al. 2017

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GB virus C (GBV-C) is a lymphotropic virus with a low level or non-existent replication in the liver. The interaction between HIV-1 and GBV-C apparently reduces the progression of HIV-1 infection to AIDS and improves the quality of life of HIV-1 infected individuals. A cross-sectional study was established to determine the possible effect of HIV-1/GBV-C coinfection on HIV-1 viral load and CD4 T lymphocyte counts. Samples from 313 HIV-1 infected persons from the Virus Laboratory of the Federal University of Pará as well as demographic and clinical information were obtained from medical records. This study used a nested PCR method to determine GBV-C viremia. The prevalence of HIV-1/GBV-C coinfection was 17%. There were no significant differences in the distribution according to age, sex or ethnicity between the groups. The differences in HIV-1 viral load and CD4 T lymphocyte count between the HIV-1 and HIV-1/GBV-C groups were highly significant, indicating that coinfection results in lower viral loads and higher CD4 T lymphocyte counts compared to HIV-1 mono-infection. The results indicate a protective effect among coinfected individuals.

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The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children

Cited by 4 publications

References 21 publications

Discovery of a Novel Human Pegivirus in Blood Associated with Hepatitis C Virus Co-Infection

Discovery of a Novel Human Pegivirus in Blood Associated with Hepatitis C Virus Co-Infection

Transfusion transmission of highly prevalent commensal human viruses

GBV-C/HIV-1 coinfection is associated with low HIV-1 viral load and high CD4+ T lymphocyte count

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