The prevalence of genes encoding ESBL among clinical isolates of Escherichia coli in Iran: A systematic review and meta-analysis

Ghaderi, R; Yaghoubi, Atieh; Amirfakhrian, Razieh; Hashemy, Seyed Isaac; Ghazvini, Kiarash

doi:10.1016/j.genrep.2019.100562

Cited by 13 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, the prevalence of ESBL producing strain was 46.62%, while in a similar study in Mashhad, the prevalence of ESBL-producing E. coli was 51.6% (31). A systematic review study in Iran estimated that 75% of E. coli producing ESBL has been isolated from UTI infection, and the prevalence of TEM, SHV, and CTX-M genes were 51%, 37% and 45% respectively (32). Based on the results of this study and our results, the prevalence of the TEM gene in Ardabil province is lower than in other provinces.…”

Section: Discussionsupporting

confidence: 52%

Prevalence of the Integrons and ESBL Genes in Multidrug-Resistant Strains of Escherichia coli Isolated from Urinary Tract Infections, Ardabil, Iran

Barzegar

Arzanlou

Teimourpour

et al. 2022

Iran J Med Microbiol

View full text Add to dashboard Cite

Background and Aim: Integrons play an essential role in disseminating drug resistance genes among bacteria. The aim of this study was to determine the prevalence of integrons, and Extended-Spectrum β-Lactamase (ESBL) genes in Escherichia coli (E. coli) isolates collected from patients with urinary tract infection (UTI) referred to teaching hospitals in Ardabil, Iran. Materials and Methods:In this descriptive, cross-sectional study (2017)(2018), 163 isolates of E.coli were collected from patients with UTI. The drug susceptibility pattern of these isolates to 12 common antibiotics was investigated using the disk diffusion method based on CLSI guidelines. The prevalence of class 1, 2 ,3 integrons and ESBL genes was verified by the PCR method. Finally, the genetic variation of isolates was analyzed using the ERIC-PCR method.Results: Of 163 isolates, 138 (84.7%) isolates were multidrug-resistance (MDR) strains. The lowest and highest antibiotic resistance was reported to nitrofurantoin and ampicillin, with a resistance rate of 1.2% and 89.6%, respectively. The incidence of class 1 and 2 integrons was obtained in 39.9% and 14.1% of the isolates, respectively. Class 3 integron was not found in any of the isolates. Based on the ERIC-PCR fingerprinting method, 4 ERIC types were detected. Conclusion:Our study showed that E. coli isolates taken from patients mainly were MDR strain and resistant to many of the common antibiotics used to treat urinary tract infections. Using the correct dose of medication and multidrug therapy would be effective in reducing the incidence of antibiotic resistance.

show abstract

Section: Discussionsupporting

confidence: 52%

Prevalence of the Integrons and ESBL Genes in Multidrug-Resistant Strains of Escherichia coli Isolated from Urinary Tract Infections, Ardabil, Iran

Barzegar

Arzanlou

Teimourpour

et al. 2022

Iran J Med Microbiol

View full text Add to dashboard Cite

show abstract

“…24 Based on a comprehensive meta-analysis conducted in Iran, the blaTEM (51%), blaCTXM (45%), and blaSHV (37%) genes were the most prevalent ESBL genes in Iran. 25 All over the world, the isolates carrying broad-spectrum beta-lactamase genes are considered one of the most important challenges of health care systems, as the results of studies have shown that the simultaneous resistance against different antibiotics is high in this group of bacteria. [25][26][27][28] It has been reported that ESBL genes are located within mobile genetic elements such as plasmids and integrons, therefore, they can be transferred between different bacteria and cause the spread of drug-resistant infections.…”

Section: Discussionmentioning

confidence: 99%

“…25 All over the world, the isolates carrying broad-spectrum beta-lactamase genes are considered one of the most important challenges of health care systems, as the results of studies have shown that the simultaneous resistance against different antibiotics is high in this group of bacteria. [25][26][27][28] It has been reported that ESBL genes are located within mobile genetic elements such as plasmids and integrons, therefore, they can be transferred between different bacteria and cause the spread of drug-resistant infections. [20][21][22][23][24][25] Continuous monitoring of the antibiotic resistance pattern and the mechanisms causing antibiotic resistance, such as the production of ESBL, is of pivotal importance, and the results can help a lot in making decisions regarding the implementation of infection control programs.…”

Section: Discussionmentioning

confidence: 99%

“…[25][26][27][28] It has been reported that ESBL genes are located within mobile genetic elements such as plasmids and integrons, therefore, they can be transferred between different bacteria and cause the spread of drug-resistant infections. [20][21][22][23][24][25] Continuous monitoring of the antibiotic resistance pattern and the mechanisms causing antibiotic resistance, such as the production of ESBL, is of pivotal importance, and the results can help a lot in making decisions regarding the implementation of infection control programs. The lack of examination of other broad-spectrum beta-lactamase genes and antibiotic resistance mechanisms, as well as limited study period are the limitations of the present study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Extended-Spectrum Beta Lactamase blaCTXM, blaSHV and blaTEM Genes in Escherichia coli Strains Isolated from Clinical Samples of Patients With Urinary Tract Infections

Saeid

Yazdanpour

Khademi

et al. 2022

Int J Basic Sci Med

View full text Add to dashboard Cite

Introduction: Urinary tract infections (UTIs) are the most prevalent infections in patients worldwide. Escherichia coli is considered as the most prevalent etiological agent of UTIs. The prevalence of extended-spectrum beta-lactamase (ESBL)-producing isolates is a health care concern worldwide. The aims of this study was to determine antibiotic resistance profiles and the prevalence of the blaCTXM, blaSHV, and blaTEM genes in E. coli isolated from clinical samples obtained from patients with UTIs. Methods: From September 2019 to March 2021, a total of 1200 urine samples were collected and analyzed from patients suspected of having UTI referred to Amir-Al-Momenin hospital of Zabol, Sistan and Baluchistan province, south-east of Iran. Antibiotic resistance patterns and the prevalence of the blaCTXM, blaSHV and blaTEM genes were determined using the disk diffusion method and PCR, respectively. Results: The isolates were mostly resistance against ampicillin and trimethoprim-sulfamethoxazole, with 66% and 54% of all isolates being resistant. Also, the isolates investigated were highly susceptible against meropenem and gentamycin (95%). The prevalence of the blaCTX, blaSHV, and blaTEM genes was 22%, 30%, and 24%, respectively. Conclusion: Resistance against ampicillin and trimethoprim-sulfamethoxazole was high, therefore their prescription must be restricted. In addition, the expressions of the blaCTXM, blaSHV, and blaTEM genes were alarmingly high. In order to control the spread of infections by these isolates, constant monitoring of antibiotic resistance patterns is necessary.

show abstract

“…producing extended‐spectrum β‐lactamases (ESBLs), such as SHV and TEM types, are a major cause of hospital‐acquired infections (Deepti and Deepthi, 2010). ESBLs, which are characterized by their ability to mediate resistance to all penicillins, third and fourth generation cephalosporins and aztreonam, but not to carbapenems and 7‐alpha‐methoxy‐cephalosporins (cephamycins), and are inhibited by β‐lactamase inhibitors such as clavulanic acid, have become a worldwide problem (Ghaderia et al ., 2020). Furthermore, it is a ubiquitous species often found in a variety of environmental sources and has shown high tolerance to many metal ions like nickel, copper, cobalt, mercury, cadmium, lead, arsenate and arsenite (Daware et al ., 2012).…”

Section: Introductionmentioning

confidence: 99%

First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia

Miloud

Ali

Boutiba³

et al. 2020

Water & Environment J

View full text Add to dashboard Cite

Klebsiella pneumoniae, ubiquitously found in a variety of environmental sources, is an important pathogen in burn wounds and nosocomial infections. Burn wounds have been commonly treated with silver compounds, which are also used in a multitude of (non)medical products. As the latter increased silver discharge into different environments, we evaluated and compared silver resistance in K. pneumoniae isolates collected from patients hospitalized at the Charles‐Nicolle hospital (Tunis, Tunisia) with isolates collected from different metal polluted waters in the north and south of Tunisia. All K. pneumoniae isolates harboured blaTEM‐1 and blaSHV‐1. In addition, all clinical isolates showed a multidrug phenotype and harboured the blaCTX‐M‐15, blaOXA‐1 and blaNDM‐1. Furthermore, all isolates showed resistance to silver nitrate. The silver resistance determinant, screened via the silE gene, was located for all isolates on a large plasmid with a size similar to pMG101. This study showed cross‐resistance between silver and beta‐lactams in clinical as well as environmental K. pneumoniae isolates from Tunisia and showed for the first time that NDM‐1‐producing K. pneumoniae developed resistance to silver.

show abstract

The prevalence of genes encoding ESBL among clinical isolates of Escherichia coli in Iran: A systematic review and meta-analysis

Cited by 13 publications

References 36 publications

Prevalence of the Integrons and ESBL Genes in Multidrug-Resistant Strains of Escherichia coli Isolated from Urinary Tract Infections, Ardabil, Iran

Prevalence of the Integrons and ESBL Genes in Multidrug-Resistant Strains of Escherichia coli Isolated from Urinary Tract Infections, Ardabil, Iran

Prevalence of Extended-Spectrum Beta Lactamase blaCTXM, blaSHV and blaTEM Genes in Escherichia coli Strains Isolated from Clinical Samples of Patients With Urinary Tract Infections

First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia

Contact Info

Product

Resources

About