The prevalence of Group B Streptococus recto-vaginal colonization and antimicrobial susceptibility pattern in pregnant mothers at two hospitals of Addis Ababa, Ethiopia

Woldu, Zufan Lakew; Teklehaimanot, Tatek Gebreegziabher; Waji, Sisay Teklu; Gebremariam, Mahlet Yigeremu

doi:10.1186/1742-4755-11-80

Cited by 34 publications

(51 citation statements)

References 9 publications

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“…A high rate of GBS colonization is often obtained if women are followed up for a certain period and both the rectal and vaginal sites are investigated which was the case in the current study. GBS colonization rates are known to vary with different geographical localities and different communities [2,16]. This is attributed to variation in socio-economic factors and sampling techniques.…”

Section: Discussionmentioning

confidence: 99%

“…This is attributed to variation in socio-economic factors and sampling techniques. Cultural, ethnic and genetic factors play a role in the variation of the rates of infection with GBS [2,19,20]. Lower rates are attributed to false negative culture due to inadequate swabbing technique or poor handling, specimen storage conditions, and prolonged transport.…”

Section: Discussionmentioning

confidence: 99%

“…It is also implicated in adverse pregnancy outcomes [2]. Maternal colonization has been found to be a major risk factor for invasive neonatal GBS disease within 6 days of birth [3].…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Lekala

Mavenyengwa

Moyo

et al. 2015

JGO

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Lekala

Mavenyengwa

Moyo

et al. 2015

JGO

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“…Differences in the timing of specimen collection in pregnancy, selective culture methods, and study sample size did not explain the heterogeneity [10]. In Ethiopia, the study by Muhammed et al showed that GBS colonization rates (20.6 %) were higher than reported by Lakew et al (7.2 %) [11, 12]. …”

Section: Introductionmentioning

confidence: 99%

“…In Ethiopia, few studies have been conducted on GBS [11, 12, 15–17] although infant mortality is high in this population. Until today, there are no public health policies or strategies in Ethiopia aimed at the reduction of GBS neonatal infection.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and antimicrobial susceptibility pattern of anorectal and vaginal group B Streptococci isolates among pregnant women in Jimma, Ethiopia

2016

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BackgroundStreptococcus agalactiae (group B Streptococcus, GBS) is the most frequent pathogen isolated from neonates with invasive bacterial disease and responsible for serious infections in newborns such as pneumonia, septicemia and meningitis. Infection is primarily acquired vertically from mothers colonized with GBS. However, the prevalence and antimicrobial susceptibility pattern of GBS among pregnant women in Ethiopia are less studied.MethodsThis cross-sectional study involved 126 pregnant women at 35–37 weeks of gestation attending the antenatal clinic at Jimma University Hospital. Anorectal and vaginal swabs were cultured on to Todd-Hewitt broth medium supplemented with Gentamicin and Nalidixic acid and subsequently sub-cultured on 5 % sheep blood agar followed by identification of isolates based on colonial morphology, Gram stain, catalase reaction, hippurate hydrolysis and Christie, Atkins, Munch-Petersen (CAMP) test, and testing for their susceptibility to antimicrobial agents using the Kirby–Bauer method.ResultsThe overall carriage rate of GBS was 19.0 % (24/126), and the rectal and vaginal carrier rates were 14.3 % (18/126) and 10.4 % (13/126), respectively. Concomitant vaginal and anorectal colonization was recorded in 29.2 % (7/24) of the women who were culture positive. All GBS isolates were susceptible to penicillin G, ampicillin, and vancomycin, but a considerable proportion was resistant to clindamycin (3.2 %), erythromycin (6.5 %), ciprofloxacin (9.7 %), ceftriaxone (9.7 %), norfloxacin (12.9 %), cotrimoxazole (29 %), and tetracycline (45.2 %).ConclusionThis study reveals high carriage rate of GBS among pregnant women compared to some previous studies in Ethiopia. However, further epidemiological investigations should be done in different parts of the country in order to know the actual GBS colonization rate of pregnant women and to consider the possibility of implementing prophylactic treatment to prevent potential adverse maternal and neonatal outcomes. Future studies should be conducted to reveal serotype distributions of GBS in this community.

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Antibiotic Susceptibility Patterns and Prevalence of Streptococcus Agalactiae Rectovaginal Colonization Among Pregnant Women in Iran

Dashtizade

Zolfaghari

Yousefi

et al. 2020

Rev Bras Ginecol Obstet

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Objective Streptococcus agalactiae is an important pathogen in neonates and pregnant women. Neonatal invasive infections due to S. agalactiae are life-threatening and preventive strategies for this challenge of human have become a concern. The aim of the present study was to determine the prevalence of rectovaginal colonization, related risk factors and antibiotic resistance pattern of S. agalactiae among pregnant women in Iran. Methods The present study was performed on 240 pregnant women. Vaginal and rectal swabs were obtained from all of the women and then were transferred to the laboratory. The isolation and identification of S. agalactiae was performed by standard microbiological tests and polymerase chain reaction (PCR) assay. The antimicrobial susceptibility patterns of the isolates were determined by the Kirby-Bauer disk diffusion. Polymerase chain reaction was used to detect ermB and mefA genes in erythromycin-nonsusceptible isolates. Results Out of 240 pregnant women, 16 cases (6.7%) were colonized by S. agalactiae. There is no significant association between demographic-obstetric factors and maternal S. agalactiae colonization in the pregnant women. Linezolid, vancomycin and ampicillin were the most effective antibiotics against S. agalactiae. The ermB gene was present in 6 (35.29%) S. agalactiae isolates. However, the mefA gene was not detected in any of the isolates. Conclusion Given the relatively significant prevalence of S. agalactiae colonization in the pregnant women in the present study and the risk of serious neonatal infections, the screening of pregnant mothers for the bacteria seems necessary. Our findings highlight the importance of appropriate antibiotic prophylaxis during pregnancy for the prevention of early onset S. agalactiae-neonatal infection and comorbidity.

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The prevalence of Group B Streptococus recto-vaginal colonization and antimicrobial susceptibility pattern in pregnant mothers at two hospitals of Addis Ababa, Ethiopia

Cited by 34 publications

References 9 publications

Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Risk Factors Associated with Group B Streptococcus Colonization and Their Effect on Pregnancy Outcome

Prevalence and antimicrobial susceptibility pattern of anorectal and vaginal group B Streptococci isolates among pregnant women in Jimma, Ethiopia

Antibiotic Susceptibility Patterns and Prevalence of Streptococcus Agalactiae Rectovaginal Colonization Among Pregnant Women in Iran

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