The prevalence of Helicobacter pylori infection in inflammatory bowel disease in China: A case-control study

Abstract

Background & aims Helicobacter pylori (H. pylori) infection remains high in China though the incidence of inflammatory bowel disease (IBD) has increased. Our aim was to investigate the relationship between the prevalence of H. pylori and inflammatory bowel disease. Methods Hospitalized IBD patients including Crohn’s disease (CD) and ulcerative colitis (UC) who had tested H. pylori antibody were enrolled. Controls were chose from age- and sex- matched healthy physical examination people who had H. pylori antibody test in a 1:2 fashion (IBD patients:controls). IBD medical history was recorded. All patients were typed by the Montreal classification. Mayo Clinic score and the Harvey-Bradshaw Severity Index were used to evaluate their disease activity. Patients and controls that had H. pylori eradication therapy before were excluded. Results Two hundred and sixty IBD patients including 213 CD patients and 47 UC patients, and 520 controls were involved in this study. The prevalence of H. pylori infection in IBD patients (9.6%, 25/260) and IBD newly diagnosed patients (12.1%, 8/66), as well as CD patients (8.9%, 19/213) including CD newly diagnosed patients (10.6%, 5/47) and UC patients (12.8%, 6/47) was significantly lower than controls (29.8%, 155/520) (p = 2.796*10−10, 0.007, 5.723*10−9, 0.016, 0.014), while there was no statistically difference between UC newly diagnosed patients and the controls, and IBD patients with different disease type, disease activity and treatment history. Conclusions H. pylori infection had a negative association with IBD, especially CD.

Seroprevelance of Helicobacter pylori Infection among Students of Bingham University, Karu in North-Central Nigeria

“…This result is similar to studies carried out in Netherlands with low prevalence of 1.2%, and Canada with 7.1% [26]. It is also comparable to the result of [8] in China where they reported 9.6% seropositivity.…”

“…Ding et al in China, investigated the prevalence of H. pylori infection in inflammatory bowel disease patients and recorded 9.6% seroprevalence, including newly diagnosed patients. They concluded that H. pylori infection had a negative association with inflammatory bowel disease [8].…”

Effect of sequential eradication therapy on serum osteoprotegerin levels in patients with Helicobacter pylori infection and co-existing inflammatory bowel disease

“…The limitations of the current study included the relatively small number of patients because of the low prevalence of concomitant H. pylori infection and IBD (9.6%–12.8%). 30 , 31 In addition, the effect of sequential therapy on other IBD markers was not evaluated. Moreover, the OPG level was measured only once, and there was no follow-up of participants to detect any possible change of OPG levels over time.…”

Progress in elucidating the relationship between Helicobacter pylori infection and intestinal diseases

“…However, the frequency of ulcerative colitis and Crohn’s disease is lower in H. pylori -infected individuals[ 8 - 10 ]. Meta-analyses have concluded that the risk of inflammatory bowel disease (IBD) is lower in H. pylori -infected individuals[ 39 , 40 ].…”

“…Furthermore, it has been suggested that H. pylori infection may cause irritable bowel syndrome[ 7 ]. On the other hand, the frequencies of ulcerative colitis[ 8 , 9 ], Crohn’s disease[ 8 - 10 ], and celiac disease[ 11 ] are low in H. pylori -infected individuals.…”