The Prevalence of Helicobacter Pylori Infection and the Status of Gastric Acid Secretion in Patients with Barrett's Esophagus in Japan

Abe, Yasuhiko; Ohara, Shuichi; Koike, Tomoyuki; Sekine, Hitoshi; Iijima, Katsunori; Kawamura, Masashi; Imatani, Akira; Kato, Kanefusa; Shimosegawa, Tooru

doi:10.1111/j.1572-0241.2004.30313.x

Cited by 63 publications

(57 citation statements)

References 44 publications

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“…The presence of H pylori is believed to protect against GERD and associated long-segment BE (36)(37)(38). In our series, BE patients were less likely to be H pylori-positive than were non-BE patients (10% versus 42.5%, respectively; P Ͻ 0.05), confirming the potential protective role of H pylori.…”

Section: Discussionsupporting

confidence: 70%

Prevalence of Barrett's esophagus in systemic sclerosis

Wipff¹,

Allanore²,

Soussi³

et al. 2005

Arthritis & Rheumatism

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Objective. The esophagus is the most commonly affected gastrointestinal area in systemic sclerosis (SSc). Patients with SSc frequently develop gastroesophageal reflux, esophageal injury, and sometimes, intestinal metaplasia, or Barrett's esophagus (BE), which may increase the risk of esophageal adenocarcinoma. This study sought to determine the prevalence of BE and esophageal adenocarcinoma in a cohort of SSc patients.Methods. One hundred ten SSc patients who were receiving long-term treatment with proton-pump inhibitors (PPIs) were assessed systematically by esophageal manometry and endoscopy. Esophageal biopsies were performed when macroscopic abnormalities were detected, and BE was diagnosed histologically.Results. Among the 110 patients, 14 had BE (12.7%). None of the patients with BE had adenocarcinoma, but 3 of the 14 patients (21%) had dysplasia on esophageal biopsy. Similar proportions of patients with and without BE had abnormal peristalsis and decreased lower esophageal sphincter pressure. No association between BE and other disease characteristics was demonstrated.Conclusion. In this study, 12.7% of SSc patients who had been treated with PPIs for long periods had BE, similar to the prevalence in patients with gastroesophageal reflux disease. Although none of the patients had esophageal adenocarcinoma, patients with BE should be followed up closely, particularly patients with dysplasic BE. Long-term prospective studies are warranted to determine the phenotype of SSc patients at high risk of developing dysplasia or esophageal adenocarcinoma.

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Section: Discussionsupporting

confidence: 70%

Prevalence of Barrett's esophagus in systemic sclerosis

Wipff¹,

Allanore²,

Soussi³

et al. 2005

Arthritis & Rheumatism

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“…As found in other studies, a study from Japan showed that H. pylori infection may play a protective role in the development of BE (especially LSBE), although the number of patients evaluated was limited [90]. The same group proposed that the preservation of gastric acid secretion might be important for the development of adenocarcinoma at the EGJ (including EAC) in Japanese people, irrespective of the H. pylori infection status [91].…”

Section: H Pylori Infection and Carcinogenesismentioning

confidence: 78%

Carcinogenesis of Barrett’s esophagus: a review of the clinical literature

Watari

Oshima

Fukui

et al. 2013

Clin J Gastroenterol

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Barrett's esophagus (BE) is a premalignant condition of esophageal adenocarcinoma (EAC). Although the incidence of BE has risen rapidly in the West, it is rare in Asia despite a recent increase in the prevalence of gastroesophageal reflux disease. Controversies over the definition of BE are presented because most cases show shortsegment BE, especially ultra-short BE, in Asia. Here we review possible risk factors for the development of EAC, particularly possible roles of ethnicity, specialized intestinal metaplasia (SIM), BE length, and environmental factors, such as Helicobacter pylori infection and obesity. Additionally, we summarize recent studies on the effect of chemoprevention including proton pump inhibitors, nonsteroidal anti-inflammatory drugs or aspirin in order to reduce the risk of neoplastic progression in BE patients. Although substantial knowledge of risk factors of dysplasia/EAC in BE is shown, the risk for neoplastic development may be influenced by geographic variation, study population, the presence or absence of SIM or dysplasia at baseline, and the small number of BE patients investigated. Recently, the efficiency of surveillance for BE patients has been discussed from the standpoint of cost-effectiveness. It may be too difficult to draw conclusions because no randomized clinical trials of BE surveillance have been performed.

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“…This has been found in published studies. 14,17,22,2 Furthermore, there is a stronger negative association between H. pylori infection and endoscopically-demonstrated reflux oesophagitis than between H. pylori and GORD without macroscopic oesophagitis. [26][27][28] …”

Section: H Pylori and Gord Complications In East Asiamentioning

confidence: 99%

“…This is indeed the case: studies from these countries consistently show a strong negative association. [12][13][14][15][16][17] The effect of cytokine gene polymorphism…”

Section: H Pylori and Gord Complications In East Asiamentioning

confidence: 99%