The prevalence of helicobacter pylori infection in diabetic patients and its relation to the presence of gastrointestinal tract complications

Abstract

Background: it's well known that diabetic patients are more prone to infection. In these patients, chronic infections are frequent and severe due to impairment of their immune system. The relationship between H. pylori infection and diabetes mellitus have shown in some studies but the relationships remain controversial. Aim of The study: was to determine the prevalence of Helicobacter pylori infection (H. pylori) among diabetic patients (type1 and type 2 diabetes mellitus) and the relation of H. pylori infection to gastrointestinal (GI) complications in diabetics. Subjects and methods: the study included 100 subjects were divided into 2 groups. Group I 50 patients with diabetes mellitus and have dyspeptic symptoms, group II 50 non-diabetic with dyspeptic symptoms. This is a case and control study comparison of diabetic and non-diabetic groups. The study was conducted at Police Hospital Cairo during the period from (January-December 2012). Methods: H. pylori were assessed by H. pylori stool antigen (HpSAg) test among diabetic and non-diabetic group. Results: a positive cases for H. pylori infection by (HpSAg) test was 61.1% in type 1 diabetic patients and 65.6% in type 2 diabetic patients compared to 50% of the non-diabetic group (p 0.36) non significant (N.S). The prevalence of gastrointestinal symptoms in H. pylori positive diabetic patients as regarding dyspepsia (62.5%), early satiety (56.25%), heart burn (62.5%), bloating (25%), diarrhea (15.63%), constipation (25%), nausea (43.75%), vomiting (9.38%) and abdominal pain (53.13%), but by comparison with negative diabetic group these was statistically insignificant. Glycosylated Hb (HBA1c) was higher among positive cases, but yet not significant, (p 0.07). Also, FBS (p 0.08) and PPBS (p 0.1) were not significant. The Presence of H. pylori not associated with increase duration of diabetes. The mean age of diabetic patients positive for H. pylori was 48.750±11.09 years compared to 40.167±12.76 years in diabetic patients negative for H. pylori infection (p 0.017) significant (s). Age and BMI was higher among those positive for H. pylori in studied cases. Conclusion: the study reported no significant association between H. pylori infection and the prevalence of diabetes, but there is a borderline increased risk for H. pylori infection in diabetic among participants with a BMI greater than 25 kg/m².

Association Between Proteinuria and Active Helicobacter Pylori Infection in Non-Diabetic Patients

“…[8] Helicobacter pylori colonies over the gastric mucosa can be a trigger for an immune response through bacterial or host dependent cytotoxic agents. [6] By this way, a local inflammatory response can be triggered, although the inflammatory process is limited to the gastric mucosa, this inflammation may have a role in some extragastric disorders. [7] H. Pylori elaborates numerous enzymes that can lead to cellular damage either by direct or indirect pathways.…”