The Prevalence of Hemoglobin S and Glucose‐6‐Phosphate Dehydrogenase Deficiency in Jordanian Newborn

Talafih, Khalid; Hunaiti, Abdelrahim A.; Gharaibeh, Nayef S.; Gharaibeh, Mohammad; Jaradat, Saied

doi:10.1111/j.1447-0756.1996.tb01050.x

Cited by 12 publications

(4 citation statements)

References 9 publications

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“… 30 This rate is higher than that shown in our study. Similarly, some surveys peformed in Middle Eastern countries show that our carrier rate is lower than that reported in many other Arab countries like Bahrain (11.2 – 16.4%), 31 Iraq (6.5%), 32 Jordan (4% among females and 6% among males), 33 Libya (4.5%), 34 Tunisia (1.9%), 35 UAE (1.1%) 36 and Yemen (2.2%). 37 This difference could be explained in part by the lower rate of consanguineous marriages among the Lebanese population compared to other Arab countries.…”

Section: Discussionsupporting

confidence: 40%

Prevalence of Sickle Cell Trait in the Southern Suburbs of Beirut, Lebanon

Ariss

Younes

Matar

et al. 2016

Mediterr J Hematol Infect Dis

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ObjectiveThe objective of this study was to assess the prevalence, gender differences, and time trends of Sickle Cell Trait in the Southern Suburb of Beirut, Lebanon, as well as to highlight the importance of screening for Sickle Cell Trait carriers in this population. Another objective was to describe a new screening technique for Sickle Cell Trait carriers.MethodsThis was a retrospective cohort study carried out at a private laboratory in the Southern Suburb of Beirut, Lebanon between 2002 and 2014. The sickling test was carried out for each patient using two methods: the classical “sodium metabisulfite sickling test”, and the new “sickling test method” used in the private lab. As a confirmatory test, hemoglobin electrophoresis was run on a random sample of 223 cases which were found to be positive using the two sickling tests.ResultsA total of 899 cases were found to be positive for the sickle cell trait out of 184,105 subjects screened during the 12-year period, prevalence = 0.49% (95% CI: 0.46 – 0.52). Among the total sample, females were found to have higher prevalence, where no time trend over the studied period was noted. The haemoglobin electrophoresis method confirmed the results of this new sickling test technique among the random sample of the 223 cases.ConclusionWe found that the prevalence of sickle cell trait is lower as compared to other Arab countries, higher in females, with no significant time trend. The sickle cell test was found to be an accurate, simple and cheap test that could be easily added as a requirement for the pre-marital testing to screen for Sickle Cell Trait carriers.

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Section: Discussionsupporting

confidence: 40%

Prevalence of Sickle Cell Trait in the Southern Suburbs of Beirut, Lebanon

Ariss

Younes

Matar

et al. 2016

Mediterr J Hematol Infect Dis

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“…Co-existing HbS/β-thalassaemias were identified, some with elevated Hb F level, but this did not ameliorate the SCA clinical presentations69. In a larger study in North Jordan, the overall prevalence of HbS and β-thalassaemia was 4.45 and 5.93 per cent, respectively and the incidence of Hb AS in the newborn sample was 3-6 per cent7071. The prevalence of both HbS and beta-thalassaemia was higher in the Al-Ghor area in comparison to Ajloun and Irbid70.…”

Section: Frequency and Distribution Of Sickle Cell Gene Among Arabsmentioning

confidence: 96%

Sickle cell disease in Middle East Arab countries

El‐Hazmi¹,

Al-Hazmi²,

Warsy³

2011

Indian Journal of Medical Research

125

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The sickle cell (HbS) gene occurs at a variable frequency in the Middle Eastern Arab countries, with characteristic distribution patterns and representing an overall picture of blood genetic disorders in the region. The origin of the gene has been debated, but studies using β-globin gene haplotypes have ascertained that there were multiple origins for HbS. In some regions the HbS gene is common and exhibits polymorphism, while the reverse is true in others. A common causative factor for the high prevalence and maintenance of HbS and thalassaemia genes is malaria endemicity. The HbS gene also co-exists with other haemoglobin variants and thalassaemia genes and the resulting clinical state is referred to as sickle cell disease (SCD). In the Middle Eastern Arab countries, the clinical picture of SCD expresses two distinct forms, the benign and the severe forms, which are related to two distinct β-globin gene haplotypes. These are referred to as the Saudi-Indian and the Benin haplotypes, respectively. In a majority of the Middle Eastern Arab countries the HbS is linked to the Saudi-Indian haplotype, while in others it is linked to the Benin haplotype. This review outlines the frequency, distribution, clinical feature, management and prevention as well as gene interactions of the HbS genes with other haemoglobin disorders in the Middle Eastern Arab countries.

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“…It was estimated that among males, 3.2–12% may be affected by glucose-6-phosphate dehydrogenase (G6PD) deficiency [14, 16]. In Amman, among G6PD-deficient males, G6PD Mediterranean, G6PD A– and G6PD Chatham were reported in 53.6, 14.2 and 3.6 %, respectively, while the three mutations were equally distributed among patients from Jordan valley [16]…”

Section: Genetic and Congenital Disordersmentioning

confidence: 99%

Jordan: Communities and Community Genetics

Hamamy¹,

Al-Hait

Alwan³

et al. 2006

Public Health Genomics

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The population in Jordan mounted from half a million in 1952 to 5.3 millions in 2004 and is composed of a variety of ethnic groups, the majority being Arabs. Couples nowadays tend to have fewer children, with the total fertility rate falling from 7.4 in 1976 to 3.7 in 2004. Consanguineous marriages are traditionally favored, with the preferred marriage partner being the offspring of the father’s brother. First-cousin marriages declined from 28.5% for marriages contracted between 1950 and 1979 to 19.5% for marriages contracted after 1980. In the overall population, carrier rates for β-thalassemia, α-thalassemia and sickle cell anemia are in the range of 2–4%, 3.2–12% of males have glucose-6-phosphate dehydrogenase deficiency, and the prevalences for familial Mediterranean fever and cystic fibrosis were estimated at around 0.04% each. A mandatory premarital screening program for β-thalassemia carriers commenced in June 2004. The high consanguinity rate and the large family size in Jordan have contributed to the description of a number of rare and new autosomal recessive conditions. Genetic services in Jordan are still scarce and do not cover all the country due to the major impediments of a paucity of resources and trained health professionals in the area of medical genetics. The demographic data suggest that the health system in Jordan is capable of introducing some basic community genetic services into the primary health care program through comprehensive and cost-effective programs.

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The Prevalence of Hemoglobin S and Glucose‐6‐Phosphate Dehydrogenase Deficiency in Jordanian Newborn

Abstract: A better understanding of the distributions of these genetic disorders has the potential to aid in the more efficient utilization of health care resources and improved planning.

Cited by 12 publications

References 9 publications

Prevalence of Sickle Cell Trait in the Southern Suburbs of Beirut, Lebanon

Prevalence of Sickle Cell Trait in the Southern Suburbs of Beirut, Lebanon

Sickle cell disease in Middle East Arab countries

Jordan: Communities and Community Genetics

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