The prevalence of hemoglobin Tacoma in Finland detected by HbA1c capillary electrophoresis

Kangastupa, Päivikki; Åkerman, Kari; Risku, Sari; Väisänen, Matti; Kuusela, Rutta; Romppanen, Jarkko; Kouki, Annika; Sneck, M.; Itkonen, Outi; Niemelä, Onni

doi:10.1080/00365513.2022.2164739

Cited by 3 publications

(2 citation statements)

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“…rs199598395 has been previously shown to be Finnish enriched and associated with iron deficiency anemia 22 and to have an effect on blood donation eligibility 23 . Negative association in blood donorship was also seen with rs1135071 in chromosome 11, in a known Finnish enriched Hb variant, Hb Tacoma 24 , in HBB gene. Linear regression analysis of blood service operational finger-prick Hb measurements showed a decreasing effect of rs199598395, rs1135071 and rs3130906 to hemoglobin level -2.99 g/L (p = 6.43 x 10 - 30 , 95% Cl [-3.49, -2.5]), -6.46 g/L (p = 6.66 x 10 - 28 , 95% Cl [-7.57, -5.35]) and -0.22 g/L (p = 0.002, 95% Cl [-0.32, -0.11]) respectively, and moderate increasing effect of rs9968910 and rs687621, 0.52 g/L (p = 4.03 x 10 - 22 , 95% Cl [0.42-0.62]) and to 0.25 g/L (p = 1.72 x 10 -05 , 95% Cl [0.15-0.35]), respectively (Supplementary file 2).…”

Section: Resultsmentioning

confidence: 86%

Section: Hemoglobin Related Associationsmentioning

confidence: 86%

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Genome-wide association study reveals the unique genetic structure of active blood donors

Clancy,

Toivonen,

Lauronen

et al. 2024

Preprint

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The healthy donor effect (HDE) refers to the observed lower mortality rate among blood donors compared to the general population. While membership biases such as HDE arise due to healthier individuals being more likely to participate, the extent to which it is influenced by genetic differences remains largely unclear. To elucidate the genetic basis of HDE, we conducted a genome-wide association study (GWAS) involving 53,688 active blood donors with extensive donation histories and 228,060 controls from biobank cohorts within the FinnGen project. Our results identified 2,973 genome-wide significant loci associated with repeated blood donation and impacting several health-related endpoints. Importantly, significant variants related not only to blood groups but also influenced the predisposition to somatic and mental diseases, suggesting that HDE is not solely tied to blood donation eligibility criteria. In conclusion, in this work we show that HDE is partially explained by genetic factors affecting various disease categories.

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Section: Resultsmentioning

confidence: 86%

Section: Hemoglobin Related Associationsmentioning

confidence: 86%