The prevalence of hepatitis C virus infection in β-thalassemia patients in Pakistan: a systematic review and meta-analysis

Akhtar, Shabbir; Nasir, Jamal Abdul; Hinde, Andrew

doi:10.1186/s12889-020-8414-5

Cited by 20 publications

(24 citation statements)

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“…The copyright holder for this this version posted January 25, 2022. ; https://doi.org/10.1101/2022.01.25.22269811 doi: medRxiv preprint to high in general population of Pakistan and AJK [24][25][26]. The prevalence of both HCV and HBV is very high in Pakistan when compared to advanced countries like Germany where the prevalence of both viruses ranges from 0.2% to 1.9% [27].…”

Section: Discussionmentioning

confidence: 99%

Identification of HBV and HCV transmission in multi-transfused Thalassemia patients of Azad Jammu and Kashmir, Pakistan

Mahmood¹,

Aslam²,

Zaman

et al. 2022

Preprint

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Background: Thalassemia patients need regular blood transfusion which saves their lives but increases the risk of acquiring viral infections like hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Objective(s): This study aimed to screen out the HCV and HBV infections in Thalassemia patients receiving regular blood in three centers of Azad Jammu and Kashmir (AJK), Pakistan. Materials and Methods: It was a cross sectional, multicenter study involving 224 Thalassemia patients. The study was carried out from August 2019 to January 2020 in Thalassemia centers of Sheikh Khalifa Bin Zaid hospital Rawalakot, District Headquarters hospital (DHQ) Palandari, and Combined Military Hospital (CMH) Muzaffarabad, AJK. A total of 224 patients were screened out for HCV and HBV. Indirect ELISA was carried out to detect anti HCV antibodies while direct ELISA was carried out to detect the HBsAg from all the samples using commercially available ELISA kits. Results: Overall, 12 patients (5.36%) were found to be positive for HBV while 63 (28.1%) were positive for HCV. HBV positive patients included 7 (5.69%) males and 5 (4.95%) females while HCV positive patients included 26 (41.27%) males and 37 (58.73%) female patients. Both the viruses were more common among elder patients as compared to younger patients. Conclusion: Prevalence of HCV is very high and that of HBV is moderately high among Thalassemia patients of AJK.

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Section: Discussionmentioning

confidence: 99%

Identification of HBV and HCV transmission in multi-transfused Thalassemia patients of Azad Jammu and Kashmir, Pakistan

Mahmood¹,

Aslam²,

Zaman

et al. 2022

Preprint

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“…Hepatitis B and C viruses (HBV and HCV) are common infections in patients with hemoglobinopathies, such as thalassemias, due to repetitive transfusions [ 34 , 35 ]. These infections have been associated with nephrotic-syndrome- or cholestasis-related hyperlipidemia as well as hypergammaglobulinemia due to chronic liver disease; thus, pseudohyponatremia may occur [ 36 , 37 ].…”

Section: Causes Of Hyponatremia In Hematologic Patientsmentioning

confidence: 99%

Hyponatremia in Patients with Hematologic Diseases

Koumpis

Florentin

Hatzimichael

et al. 2020

JCM

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Hyponatremia is the most common electrolyte disorder in clinical practice and is associated with increased morbidity and mortality. It is frequently encountered in hematologic patients with either benign or malignant diseases. Several underlying mechanisms, such as hypovolemia, infections, toxins, renal, endocrine, cardiac, and liver disorders, as well as the use of certain drugs appear to be involved in the development or the persistence of hyponatremia. This review describes the pathophysiology of hyponatremia and discusses thoroughly the contributing factors and mechanisms that may be encountered specifically in patients with hematologic disorders. The involvement of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion and renal salt wasting syndrome (RSWS) in the development of hyponatremia in such patients, as well as their differential diagnosis and management, are also presented. Furthermore, the distinction between true hyponatremia and pseudohyponatremia is explained. Finally, a practical algorithm for the evaluation of hyponatremia in hematologic patients, as well as the principles of hyponatremia management, are included in this review.

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“…Beta-thalassemia, with a global carrier rate of 1.5%, equating to 80–90 million subjects and an estimated 50 000–60 000 new cases annually, is considered to be one of the most prevalent genetic diseases worldwide. 1 β-thalassemia is characterized by inherited disorders in β-globin chain synthesis, which result in anemia due to hemolysis of red blood cells and erythroblasts as well as ineffective erythropoiesis. 2 - 4 Given recent progress in the management of thalassemia patients, this group of patients’ survival and quality of life have increased significantly.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Molecular Evaluation of Hepatitis C Virus Infection among Multi-transfused Thalassemia Patients in South of Iran

Farshadpour¹,

Taherkhani²

2022

Oman Med J

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Objectives: Information regarding the magnitude of hepatitis C virus (HCV) infection among thalassemia patients is of great importance for health care providers to assess blood safety and improve the quality of screening systems. Therefore, this study evaluated the prevalence, risk factors, and genotypic pattern of HCV infection among β-thalassemia patients in South Iran. Methods: This descriptive-analytical cross-sectional study was conducted from March to June 2019. All patients with β-thalassemia major from Borazjan, Bushehr, Delvar, Kangan, and Ahram cities participated in the study and attended the transfusion center of the Bushehr University of Medical Sciences located in southern Iran. Serum samples were tested for the presence of anti-HCV antibodies by an enzyme-linked immunosorbent assay. The seropositive serum samples were tested for detection of HCV viremia and genotypes by semi-nested reverse transcriptase-polymerase chain reaction and sequencing. Results: Of 125 thalassemia patients, 22 (17.6%) were positive for anti-HCV antibodies and two (1.6%) had HCV viremia with genotype 3a. HCV seroprevalence increased with age, so anti-HCV seropositive thalassemia patients had significantly higher mean age than anti-HCV seronegative patients. HCV seroprevalence was higher among female patients, residents of Kangan, patients with blood transfusion every two weeks, Fars patients, and thalassemia patients with alanine aminotransferase levels of < 20 IU/L and aspartate aminotransferase levels of > 80 IU/L. Nevertheless, anti-HCV seroprevalence among thalassemia patients was not statistically associated with these variables.Conclusions: These results indicate ongoing HCV incidence among the thalassemia population in this region. Transfusion of HCV-seronegative viremic blood units donated during the infectious window period contributes to HCV infection in thalassemia patients. These findings highlight the need to include sensitive molecular assays in the screening process of donated blood for HCV infection in Iran.

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The prevalence of hepatitis C virus infection in β-thalassemia patients in Pakistan: a systematic review and meta-analysis

Cited by 20 publications

References 24 publications

Identification of HBV and HCV transmission in multi-transfused Thalassemia patients of Azad Jammu and Kashmir, Pakistan

Identification of HBV and HCV transmission in multi-transfused Thalassemia patients of Azad Jammu and Kashmir, Pakistan

Hyponatremia in Patients with Hematologic Diseases

Prevalence and Molecular Evaluation of Hepatitis C Virus Infection among Multi-transfused Thalassemia Patients in South of Iran

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