The prevalence of high risk of obstructive sleep apnea in patients with allergic rhinitis

Wongvilairat, Surintorn; Assanasen, Paraya; Banhiran, Wish; Tantilipikorn, Pongsakorn; Bunnag, Chaweewan

doi:10.12932/ap-141218-0458

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…Previous studies reported that AR is closely related to OSA. 9 , 12 Treatments for AR, including immunotherapy, intranasal corticosteroids (ICS), and oral antihistamines, have been shown to effectively improve OSA symptoms. 10 The main mechanisms underlying the association between AR and altered sleep patterns can be summarized as follows.…”

Section: Discussionmentioning

confidence: 99%

“… 11 Compared to the general Thai population, Thai patients with AR are twice as likely to develop OSA. 12 OSA patients undergo heightened oxidative stress, resulting in a decrease in oxygen saturation, which has the potential to worsen preexisting allergic diseases. 13 , 14 Accordingly, there appears to be a close relationship between AR and OSA.…”

Section: Introductionmentioning

confidence: 99%

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Multiple Allergic Rhinitis Single Nucleotide Polymorphism Variants are Associated with Sleep-Breathing Parameters in Men with Obstructive Sleep Apnea: A Large-Scale Study

Zeng,

Xue,

Wei

et al. 2024

NSS

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Background Sleep-disordered breathing is more prevalent in individuals with allergic rhinitis (AR) than in those without AR. In addition to increased risk for sleep-disordered breathing, AR is associated with greater severity of obstructive sleep apnea (OSA) symptoms. The aim of this research study was to evaluate the association of multiple single nucleotide polymorphism (SNP) variations in AR with sleep- and breathing-related parameters in men with OSA. Methods Men who had complained of snoring were consecutively enrolled in the Shanghai Sleep Health Study of Shanghai Sixth People’s Hospital from 2007 to 2018. After rigorous screening, 5322 men were included in the analysis. Anthropometric, fasting biochemical, and polysomnographic parameters, along with 27 AR-associated SNPs were analyzed. The associations between AR-related genetic polymorphisms and OSA were determined via linear, binary, and multinomial logistic regression analyses. Results Rs12509403 had significantly positive associations with most sleep-breathing parameters. While the risk for OSA was increased by rs12509403, it was decreased by rs7717955 [odds ratio (OR) = 1.341, 95% confidence interval [CI] = 1.039–1.732, P = 0.024; OR = 0.829, 95% CI = 0.715–0.961, P = 0.013, respectively]. A graded increase in the risk of being in the highest quartile (Q4) vs the reference category (Q1) for sleep breathing indicators, especially REM-AHI and NREM-AHI, was identified by rs12509403 (OR = 1.496, 95% CI = 1.175–1.904, P = 0.001; OR = 1.471, 95% CI = 1.151–1.879, P < 0.001, respectively). Conclusion The association of multiple AR SNPs with OSA-related hypoxia and sleep indices provides a genetic explanation for the higher AR susceptibility of OSA patients. Understanding the AR-related genetic underpinnings of OSA may lead to more personalized treatment approaches.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multiple Allergic Rhinitis Single Nucleotide Polymorphism Variants are Associated with Sleep-Breathing Parameters in Men with Obstructive Sleep Apnea: A Large-Scale Study

Zeng,

Xue,

Wei

et al. 2024

NSS

View full text Add to dashboard Cite

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“…Several consistent investigations have demonstrated a relationship between OSA and an increased likelihood of asthma 10,11 . The prevalence of OSA in patients with allergic rhinitis is twice that of the general population 12 . Research has indicated that atopic dermatitis is related to sleep disorders in 47-80% of children and 33-90% of adults 13 .…”

Section: Introductionmentioning

confidence: 98%

Associations Between Obstructive Sleep Apnea and Allergic Diseases: A Two-Sample Mendelian Randomization Study

Chen,

Ma,

Zhao

et al. 2024

Preprint

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Objectives:The objective of this study was to assess the causal relationship between obstructive sleep apnea (OSA) and allergic conditions including allergic asthma, allergic rhinitis, allergic conjunctivitis, and atopic dermatitis. Design:We conducted a Mendelian randomization analysis to assess a potential causal relationship between OSA and allergic disease. Setting and participants:All candidate gene data were from the IEU GWAS database, where OSA candidate genes included 16,761 cases and 201,194 controls, and the allergic disease dataset included allergic asthma (4,859 and 135,449 controls), allergic rhinitis (7,308 and 167,849 controls), allergic conjunctivitis (9,431 and 203,517 controls), and atopic dermatitis (7,024 and 198,740 controls). Results:MR analysis using the IVW approach demonstrated that OSA was associated with a slight increase in the risk of allergic asthma (odds ratio [OR]=1.16; 95% confidence interval [CI]: 1.02–1.33; p = 0.019). Furthermore, compelling evidence emerged, indicating that OSA is associated with an elevated risk of other allergic conditions, such as allergic rhinitis (OR=1.16; 95% CI: 1.04–1.29; p = 0.006), allergic conjunctivitis (OR = 1.15; 95% CI: 1.05–1.27; p = 0.002), and atopic dermatitis (OR=1.16; 95% CI: 1.03–1.30; p=0.002). These results collectively contribute to a better understanding of the potential causal relationships between OSA and various allergic diseases. Conclusion: The findings of the two-sample MR analysis indicated that OSA exhibited a potential increased risk of allergic diseases.

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Evaluating Positional Obstructive Sleep Apnea in Children: Prevalence, Characteristics, and Risk Factors

Wang,

Huang,

Wang

et al. 2024

NSS

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Purpose This study investigates the prevalence, risk factors, and clinical characteristics of positional obstructive sleep apnea (POSA) among pediatric patients diagnosed with obstructive sleep apnea (OSA). Patients and Methods A total of 1,236 children aged 0 to 17 years who underwent nocturnal polysomnography (PSG) and completed the Sleep Questionnaire were included. After excluding those with an AHI <1, neurological or muscular disorders, or insufficient sleep time in specific positions, 908 patients remained: 158 with POSA and 750 with non-positional OSA (NPOSA). Propensity score matching (PSM) was applied at a 1:2 ratio, resulting in a final sample of 153 POSA and 306 NPOSA patients. Data analyses were performed using R software (version 4.2.3). Results The prevalence of POSA was 12.8%. After PSM, patients with POSA had a lower overall AHI (8.66 vs 10.30), REM-AHI (14.30 vs 17.40), and NREM-AHI (7.43 vs 8.77) compared to those with NPOSA. POSA patients also had a shorter total sleep time (411 vs 427 minutes), spent less time in the supine position (168 vs 225 minutes), and more time in non-supine positions (241 vs 202 minutes) than NPOSA patients. Additionally, while the supine AHI was higher in POSA patients (15.60 vs 10.30), the non-supine AHI was lower (5.00 vs 11.00) compared to NPOSA patients. The minimum oxygen saturation was slightly higher in POSA patients (0.88 vs 0.87). All differences were statistically significant (P < 0.05). Risk factors for POSA included mild OSA, allergic rhinitis, non-allergic rhinitis, and obesity. Conclusion The prevalence of POSA in children is lower than in adults, and its severity is less than that of NPOSA. Compared to NPOSA patients, POSA patients had significantly higher AHI during supine sleep and lower AHI during non-supine sleep. POSA patients also spent more time in non-supine positions, suggesting that avoiding supine sleep may help reduce apnea events. These findings highlight the importance of monitoring and managing sleep posture in POSA patients.

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The prevalence of high risk of obstructive sleep apnea in patients with allergic rhinitis

Cited by 5 publications

References 25 publications

Multiple Allergic Rhinitis Single Nucleotide Polymorphism Variants are Associated with Sleep-Breathing Parameters in Men with Obstructive Sleep Apnea: A Large-Scale Study

Multiple Allergic Rhinitis Single Nucleotide Polymorphism Variants are Associated with Sleep-Breathing Parameters in Men with Obstructive Sleep Apnea: A Large-Scale Study

Associations Between Obstructive Sleep Apnea and Allergic Diseases: A Two-Sample Mendelian Randomization Study

Evaluating Positional Obstructive Sleep Apnea in Children: Prevalence, Characteristics, and Risk Factors

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