The Prevalence of Hla Dq2 and Dq8 in Patients With Celiac Disease, in Family and in General Population

Abstract

Background: Celiac disease is an enteropathy characterized by gluten sensitivity and broad clinical aspect. Has a multifactorial cause and depends on genetic, immunological and environmental factors for its development. The genetic influence is given mostly by the human leukocyte antigens HLA DQ2 and DQ8. Aim: To evaluate the prevalence of human leukocyte antigens DQ2 and DQ8 in three different groups: patients with celiac disease, first-degree relatives and the general population. Method: Retrospective analysis that evaluated serologic and endoscopic data of 74 patients with celiac disease and 109 non-celiac, which were subdivided into two subgroups: non-celiac who had first-degree relatives with celiac and non-celiac who did not. All patients underwent laboratory examination for screening genetic sensitivity given by HLA DQ2 and HLA DQ8 by. Results: The presence of HLA DQ2 and DQ8 was identified in 98,4% of 74 celiac patients, of which 79,7% had only HLA DQ2; 8,1% had only HLA DQ8 and 10,8% had both antigens histocompatibility. In the group of relatives of celiac patients, were included 29 patients; among them, 89,6% had HLA DQ2 and/or DQ8; 76% only the HLA DQ2, 10,3% only HLA DQ8 and 3,4% presented both human leukocyte antigens (HLA). Conclusion: HLA DQ2/DQ8 was present in 98,4% of celiac patients; 89,6% relatives of celiac family and in 55,4% of people from the general population without family celiac.

The distribution of HLA DQ2 and DQ8 haplotypes and their association with health indicators in a general Danish population

“…When counting only HLA DQ2.5cis and DQ8 the percentages in our study were: DQ2.5cis: 25% (572/2293), DQ8: 16% (361/2293), and 2.5cis and/or DQ8: 41% (933/ 2293), comparable to the 22% among the control group in a Swedish study for DQ2.5, 26 but higher for DQ8 than numbers from Mexico and Brazil. 27,28 Compared with the prevalence table of different populations in Alarida et al, 29 our numbers are higher for DQ2 (DQ2:31%/DQ2.5 25% vs 23%), but comparable for DQ8 (DQ8 16% vs 28.3%), and the Scandinavian numbers from the table (11% DQ2 and 15% DQ8) are lower than ours. Our HLA DQ2/8 prevalence is also higher than the one found in a screening study from Latvia comparable to our study.…”

Celiac disease and risk of sarcoidosis: A systematic review and meta‐analysis

“…[15][16][17][18] Shared genetic predisposition, especially HLA-DR3 and immune cross-reactivity between gluten proteins and self-antigens could be the biological links behind the two diseases. [19][20][21] This association was later observed in epidemiological studies as well although the results were inconsistent. [21][22][23][24] This systematic review and meta-analysis was conducted with the aim to summarize all available evidence to assess the risk of sarcoidosis among patients with celiac disease compared with individuals without celiac disease.…”

“…Interestingly, several case reports have suggested a possible relationship between celiac disease and sarcoidosis . Shared genetic predisposition, especially HLA‐DR3 and immune cross‐reactivity between gluten proteins and self‐antigens could be the biological links behind the two diseases . This association was later observed in epidemiological studies as well although the results were inconsistent .…”

Prevalence and Characterization of Self-Reported Gluten Sensitivity in The Netherlands

“…There are some indications that NCWS belongs to the group of the gluten-related disorders. The relatively large number of relatives with CD in srGS individuals could indicate a shared (genetic) predisposition, although current literature is not consistent about the relationship between HLA-DQ2 and NCWS [26,27,28]. Another indication for (mild) immune activation in NCWS comes from a study which showed that serum levels of soluble CD14 and lipopolysaccharide-binding protein as well as antibody reactivity to microbial antigens are elevated in NCWS patients with resolution after a GFD [29].…”