The prevalence of Hymenoptera venom allergy in adults: The results of a very crowded city in Euroasia

Gelincik, Aslı; İşsever, Halim; Ünal, Derya; Işık, Erol; Demirtürk, Mustafa; Gül, Hülya; İliaz, Raim; Kara, Erdal; Ertek, Belkıs; Özşeker, Ferhan; Çolakoğlu, Bahattin; Büyüköztürk, Suna

doi:10.1016/j.alit.2014.10.001

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…A significant majority of the stings in our study group were attributed to Apis mellifera. This is consistent with previous studies conducted both in children [12,13] and adults [14] Compared to the present study, the rates of LLR and GCR were 4-to 5-fold higher in Izmir and Israeli studies [9,11]. The prevalence of SR found in our study was similar to rates reported in Ireland [10] and Izmir [11], but was approximately 5-fold higher in the Israeli study [9].…”

Section: Discussionsupporting

confidence: 92%

Prevalence and characteristics of Hymenoptera venom allergy in urban school children aged 6 to 18 years living in Trabzon

Baba

Kaya²,

Abul³

et al. 2021

Turk J Med Sci

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Background/aim Hymenoptera venom allergy is one of the leading causes of systemic allergic reactions in both adults and children. The present study was conducted to evaluate the prevalence and characteristics of Hymenoptera venom allergy in urban school children aged 6 to 18 years living in Trabzon. Materials and methods In this cross-sectional, two-level survey study, children were recruited using random sampling of public primary and secondary schools. Firstly, parents were asked about their child’s age and sex and whether their child had ever been stung by any kind of bee. When they responded “yes” to the last question, they attended a face-to-face interview at the outpatient clinic for the second part of the survey, which included information about history of insect stings and the presence of atopic diseases. Results Of 17,000 children, 7904 (46.5%; 3718 males, 47.0%) returned the first-level questionnaire. A total of 4312 (54.5%) were stung at least once in their lifetime. Males had a significantly higher risk of being stung (59.4%, odds ratio: 1.44, 95% confidence interval: 1.32–1.58, p < 0.0001). The second-level questionnaire was completed for 545 (12.6%) of the children. Of 950 stings reported in 545 children, 5.2% were large local reactions (LLRs), 1.9% were generalized cutaneous reactions (GCRs), and 1.3% were systemic reactions (SRs). The stinging insect was Apis mellifera and Vespula in 66.2% and 33.8% of stings, respectively (p < 0.001). Conclusion Hymenoptera stings are common in urban school children living in Trabzon. The most common type of allergic reaction is LLR and the most reported stinging insect is Apis mellifera .

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Section: Discussionsupporting

confidence: 92%

Prevalence and characteristics of Hymenoptera venom allergy in urban school children aged 6 to 18 years living in Trabzon

Baba

Kaya²,

Abul³

et al. 2021

Turk J Med Sci

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“…The prevalence of systemic reactions due to Hymenoptera stings in the general adult population was reported as between 1.2 and 4.3 % in Turkey, which was in line with representative studies from Europe and US (Gelincik et al 2015 ; Tankersley and Ledford 2015 ). However, the Quality of Life scores of patients with venom allergy and especially in those receiving VIT has not yet been evaluated in Turkey.…”

Section: Introductionsupporting

confidence: 87%

Quality-of-life in insect venom allergy: validation of the Turkish version of the “Vespid Allergy Quality of Life Questionnaire” (VQLQ-T)

et al. 2016

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Purpose“Vespid Allergy Quality of Life Questionnaire (VQLQ)” has been used to assess psychological burden of disease. The aim of this study was to evaluate validity, reliability and responsiveness to interventions of the Turkish version.MethodsThe Turkish language Questionnaire (VQLQ-T) was administered to 81 patients with bee allergy and 65 patients with vespid allergy from different groups to achieve cross-sectional validation. To establish longitudinal validity, the questionnaire was administered to 36 patients treated with venom immunotherapy.ResultsThe cross-sectional validation in patients with vespid venom allergy showed a correlation coefficient of 0.97 (Cronbach α). Spearman’s correlation coefficient of the pretreatment VQLQ-T score with Expectation of Outcome (EoO) questionnaire score was 0.55 (p < 0.001). After treatment, correlation between VQLQ-T score and EoO score was 0.64 (p = 0.003) in these patients. The cross-sectional instrument validation for non-beekeepers with bee venom allergy yielded a correlation coefficient of 0.96 (Cronbach α). Spearman’s correlation coefficient between pretreatment VQLQ-T score and EoO score was 0.47 (p < 0.001) and after treatment, correlation between VQLQ-T score and EoO score was 0.78 (p = 0.008) in these patients. These findings indicate cross-sectional validity of VQLQ-T. In the longitudinal validation, there was a positive correlation between EoO and VQLQ-T with a correlation coefficient of 0.562 (p < 0.001). While mean (±SD) VQLQ-T score was 5.27 (±1.29) in pretreatment, it was 2.78 (±1.01) after treatment (p < 0.001). The correlation between the mean change in VQLQ-T score and the mean change in EoO score was 0.42 (p = 0.011).ConclusionsThe Turkish version of VQLQ-T enables measurement of Quality of Life (QoL) in patients with either vespid or bee venom allergy. Furthermore, responsiveness of this instrument demonstrates the questionnaire’s ability to detect changes over time.

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“…In our study, as well as the studies of Hirata et al, Seob Shin et al, and Bemanian et al, males were more frequent than females [ 18 – 20 ]. Gelincik et al found that males and females had the same prevalence of Hymenoptera venom allergies in Istanbul [ 21 ]. This difference may be attributed to the culture effect such as the influence of wearing a hijab on women in some countries, and the higher frequency of men in difficult jobs such as agriculture, animal husbandry, and beekeeping.…”

Section: Discussionmentioning

confidence: 99%

“…In a study by Yavuz et al, bronchial asthma and allergic rhinitis were identified in 25% and 17.1% of children with Hymenoptera venom allergies, respectively [ 25 ]. As mentioned in the literature, atopic diseases could not be considered a predictor of developing hypersensitivity to Hymenoptera sting [ 21 , 26 ]. Compared with individuals with mono-sensitization to Hymenoptera venom, an insignificantly higher prevalence of atopic diseases (28.8% vs. 42.1%) was observed in patients with dual-sensitization [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms

Bemanian,

Shokouhi Shoormasti,

Arshi

et al. 2024

Allergy Asthma Clin Immunol

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Background The poly-sensitization to Hymenoptera venom makes it difficult to select genuine allergens for immunotherapy and increases patients’ costs. The objective of this study was to determine the culprit allergen in dual or triple-sensitized patients to three Hymenoptera venoms through molecular diagnosis and evaluating the results of incorporating the molecular diagnosis with skin tests. Methods Thirty-two patients with anaphylactic reactions and dual or triple-sensitization to Hymenoptera venoms in skin tests entered this study. IgE-sensitization to whole extracts and molecules of Apis mellifera (Api m), Vespula vulgaris (Ves v), and Polistes dominulus (Pol d) was evaluated utilizing ALEX or ImmunoCAP. Results Twenty-nine patients (90.6%) were male. IgE-sensitization to at least one of the allergenic molecules related to Apis mellifera, Vespula vulgaris, and Polistes dominulus was seen in 59.4, 53.1, and 21.9%, respectively. Among 32 patients, 14 (43.8) and 8 (25%), were mono-sensitized to Api m and Ves v components in ALEX, respectively. Double sensitization to Hymenoptera was identified in 18.8% of patients in ALEX. Api m 1+/Api m 2−/Api m 10− and Ves v 1+/Ves v 5+ demonstrated the most prevalent sensitizations patterns in our patients. Conclusions The molecular diagnosis of IgE-sensitization to Hymenoptera venoms can be valuable, especially in patients who show dual or triple-sensitization in skin tests, as the ALEX results revealed mono and double-sensitization to Hymenoptera venoms in 22 and 6 patients, respectively. Regarding the high cost and adverse reactions of venom immunotherapy, especially for two or three venoms, incorporating the molecular diagnosis alongside skin tests for accurate diagnosis of the culprit venom could help decrease costs for patients.

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The prevalence of Hymenoptera venom allergy in adults: The results of a very crowded city in Euroasia

Abstract: The prevalence of Hymenoptera sting reactions in our geographical region is comparable with other European studies. There is a need to increase the awareness of adrenaline in the emergency management of insect sting anaphylaxis and venom immunotherapy in the prophylaxis.

Cited by 11 publications

References 16 publications

Prevalence and characteristics of Hymenoptera venom allergy in urban school children aged 6 to 18 years living in Trabzon

Prevalence and characteristics of Hymenoptera venom allergy in urban school children aged 6 to 18 years living in Trabzon

Quality-of-life in insect venom allergy: validation of the Turkish version of the “Vespid Allergy Quality of Life Questionnaire” (VQLQ-T)

The role of molecular diagnosis in anaphylactic patients with dual or triple-sensitization to Hymenoptera venoms

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