BACKGROUND 1.1 | The durability of the childhood obesity epidemicChildhood obesity is an epidemic in the United States. 1,2 In the past two decades, childhood obesity rates have continued to rise despite intensified prevention efforts. 2,3 Most recent estimates indicate that 19.7% of Americans between 2 and 19 years of age have obesity. 4 Furthermore, among infants, nearly 10% have excess weight for their height, 5 and 10%-50% experience a pattern of rapid weight gain in the first 24 months of life. 6 Notably, one recent national birth cohort found that rapid weight gain during the first 24 months of life resulted in a twofold increase in overweight or obesity at 3 and 5 years of age, respectively. 7 Hence, arresting rapid weight gain before early childhood (3-5 years) is vital for the prevention of child obesity. Consequences of obesity during infancy and early childhood span almost every health area and can lead to chronic health conditions in adulthood that cause significant impairments and disabilities. 3 Thus, further work is needed to identify mechanisms influencing the development of obesity at early critical life points.Recently, greater attention has recently been directed toward obesity prevention during the first 2 years of life (0-24 months). 8 However, randomized prevention approaches have yielded very limited effects. For instance, the Early Prevention of Obesity in Childhood (EPOCH) Collaboration conducted a prospective meta-analysis 9 on data accrued from four randomized controlled trials that addressed key targets identified for obesity prevention. Obesity prevention targets consisted of extended breastfeeding duration, introduction of table foods at the appropriate time (6 months), low intakes of nutrient-poor foods, responsive feeding practices, limited screen exposure, and ample amounts of sleep and activity. 9 Findings revealed that at 18-24 months, participants in the intervention condition displayed a mere 2% decrease in the prevalence of overweight and obesity relative to the control group. Similarly, in a recent review of 29 randomized controlled trials conducted among infants that included a minimum follow-up duration of 24 months, 10 only 7% of trials (2/29) found the intervention to have a positive effect on BMI zscores (with small effect sizes), and a third trial reported that children in the treatment condition had a lower prevalence of obesity than their control counterparts, yet mean BMI scores were comparable for all participants in the cohort. Taken together, this evidence demonstrates that sustained management of childhood obesity during infancy and early childhood years is modest, at best. Therefore, Tera L Fazzino and Kai Ling Kong have equal contribution.